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Showing 1–3 of 3 results
Advanced filters: Author: Ka-Hei Siu Clear advanced filters

  • A modular protein engineering strategy was developed to shuttle transporters and integral membrane enzymes folded in the endoplasmic reticulum to the peroxisomal membrane. This approach expands the repertoire of biosynthetic pathways that can be compartmentalized in the peroxisome.

    • Ka-Hei Siu
    • Victoria Lee
    • John E. Dueber
    Research
    Nature Chemical Biology
    Volume: 21, P: 1544-1553

  • Engineering of toehold-gated guide RNA (thgRNA) by tethering toehold riboswitches to sgRNAs enables the activation of CRISPR–Cas9 genome editing or transcriptional regulation in response to complementary synthetic or endogenous cellular RNAs.

    • Ka-Hei Siu
    • Wilfred Chen
    Research
    Nature Chemical Biology
    Volume: 15, P: 217-220

  • Biomolecular condensates have emerged as a promising strategy to control metabolic reactions in living cells. Here the authors use mathematical modeling to uncover the key physical parameters that govern the outcomes of metabolic reactions modulated by condensates. These governing principles are then demonstrated experimentally by modulating the biosynthesis of metabolites in Saccharomyces cerevisiae.

    • Dongheon Lee
    • Mackenzie T. Walls
    • Lingchong You
    Research
    Nature Chemical Engineering
    Volume: 2, P: 198-208