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  • Secondary acute myeloid leukemias (sAMLs) evolving from myeloproliferative neoplasms (MPNs) associate with poor prognosis. Here authors identify RSK1 as a vulnerability for MPN and sAML and show the efficacy of a first-in-class RSK inhibitor, PMD-026, against these types of myeloid malignancies.

    • Tim Kong
    • Angelo B. A. Laranjeira
    • Stephen T. Oh
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20