Nature Search

A database of naturally occurring human urinary peptides and proteins for use in clinical applications

Petra Zürbig
Joshua Coon
Philippe Schmitt-Kopplin
ResearchOpen Access12 Oct 2007
Nature Precedings

P: 1
A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense

Integrin-based therapeutics could block inflammatory processes but they also impair host defence, limiting their usefulness. Here the authors report an anti-Mac1 antibody that blocks its interaction with pro-inflammatory ligand CD40L but not other ligands, and show that it can protect against sepsis in mice.

Dennis Wolf
Nathaly Anto-Michel
Andreas Zirlik
ResearchOpen Access06 Feb 2018
Nature Communications

Volume: 9, P: 1-11
Room-temperature spin-spiral multiferroicity in high-pressure cupric oxide

As ferroelectric and magnetic ordering coexist in multiferroic materials, they might be used for memory applications, but only if the multiferroic phase is stable at room temperature. Here, the authors find such a phase in cupric oxide, whose spin-spiral multiferroicity is stabilized by pressure.

Xavier Rocquefelte
Karlheinz Schwarz
Jeroen van den Brink
Research23 Sept 2013
Nature Communications

Volume: 4, P: 1-7
Piezo1 expression in neutrophils regulates shear-induced NETosis

Neutrophils undergo shear stress in the circulation and mechano-sensing is known to impact neutrophil biology. Here the authors show that activation of Piezo1 by shear stress triggers a sequence of cellular events leading to NETosis.

Sara Baratchi
Habiba Danish
Karlheinz Peter
ResearchOpen Access22 Aug 2024
Nature Communications

Volume: 15, P: 1-14
Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites

C-reactive protein is a pentameric protein secreted by the liver in response to injury and infection. Here Braiget al. show that conformational changes in CRP on the surface of monocyte-derived microvesicles enable binding of complement C1q and lead to activation of the complement cascade and aggravation of inflammation.

David Braig
Tracy L. Nero
Steffen U. Eisenhardt
ResearchOpen Access23 Jan 2017
Nature Communications

Volume: 8, P: 1-19
Humanizing mouse thrombi

A new mouse model with humanized blood vessels will facilitate testing of antiplatelet therapies.

Ingo Ahrens
Karlheinz Peter
News & Views01 Jan 2008
Nature Biotechnology

Volume: 26, P: 62-63
Revised rates for the stellar triple-α process from measurement of ¹²C nuclear resonances

Hans O. U. Fynbo
Christian Aa. Diget
The ISOLDE Collaboration
Research13 Jan 2005
Nature

Volume: 433, P: 136-139
The interface between silicon and a high-k oxide

Clemens J. Först
Christopher R. Ashman
Peter E. Blöchl
Research01 Jan 2004
Nature

Volume: 427, P: 53-56
Near-infrared autofluorescence induced by intraplaque hemorrhage and heme degradation as marker for high-risk atherosclerotic plaques

Atherosclerosis diagnosis relies primarily on imaging and early detection of high-risk atherosclerotic plaques is important for risk stratification of patients and stabilization therapies. Here Htun et al. demonstrate that vulnerable atherosclerotic plaques generate near-infrared autofluorescence that can be detected via emission computed tomography.

Nay Min Htun
Yung Chih Chen
Karlheinz Peter
ResearchOpen Access13 Jul 2017
Nature Communications

Volume: 8, P: 1-16
Multi-targeted ¹H/¹⁹F MRI unmasks specific danger patterns for emerging cardiovascular disorders

The prediction of major cardiovascular events is still an unsolved problem. Here, the authors present a multi-color, multi-targeted non-invasive imaging technology that allows reliable in vivo identification of silent but prognostically highly relevant danger patterns prior to myocardial infarction in mice.

Ulrich Flögel
Sebastian Temme
Bodo Levkau
ResearchOpen Access06 Oct 2021
Nature Communications

Volume: 12, P: 1-12
Chip-based digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction patients

Samuel Robinson
Marie Follo
Marcus Hortmann
Research30 Nov 2017
Acta Pharmacologica Sinica

Volume: 39, P: 1217-1227
Comparative gene-expression profiling of the large cell variant of gastrointestinal marginal-zone B-cell lymphoma

Thomas F. E. Barth
Johann M. Kraus
Peter Möller
ResearchOpen Access20 Jul 2017
Scientific Reports

Volume: 7, P: 1-8
Quantitative proteomic landscape of unstable atherosclerosis identifies molecular signatures and therapeutic targets for plaque stabilization

Protein signatures of unstable and stable atherosclerosis are defined by quantitative proteomics using a preclinical mouse model of plaque instability/rupture.

Yung-Chih Chen
Meaghan Smith
Karlheinz Peter
ResearchOpen Access13 Mar 2023
Communications Biology

Volume: 6, P: 1-11
Theoretical Investigation of the Magnetic Exchange Interactions in Copper(II) Oxides under Chemical and Physical Pressures

Xavier Rocquefelte
Karlheinz Schwarz
Peter Blaha
ResearchOpen Access22 Oct 2012
Scientific Reports

Volume: 2, P: 1-5
Molecular Imaging of Activated Platelets Allows the Detection of Pulmonary Embolism with Magnetic Resonance Imaging

Timo Heidt
Simon Ehrismann
Constantin von zur Muhlen
ResearchOpen Access03 May 2016
Scientific Reports

Volume: 6, P: 1-9
Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation

Abnormal cytoplasmic aggregates of FUS are a hallmark of some forms of amyotrophic lateral sclerosis (ALS). Here, using neurons derived from patients with FUS-ALS, the authors demonstrate that impairment of PARP-dependent DNA damage signaling is an event that occurs upstream of neurodegeneration and cytoplasmic aggregate formation in FUS-ALS.

Marcel Naumann
Arun Pal
Andreas Hermann
ResearchOpen Access23 Jan 2018
Nature Communications

Volume: 9, P: 1-17
Highly Sensitive Detection of Minimal Cardiac Ischemia using Positron Emission Tomography Imaging of Activated Platelets

Melanie Ziegler
Karen Alt
Karlheinz Peter
ResearchOpen Access02 Dec 2016
Scientific Reports

Volume: 6, P: 1-10
P₂Y₁₂ receptor blockers are anti-inflammatory drugs inhibiting both circulating monocytes and macrophages including THP-1 cells

Patrick M. Siegel
Laura Sander
Karlheinz Peter
ResearchOpen Access31 Aug 2021
Scientific Reports

Volume: 11, P: 1-16
Current and future antiplatelet therapies: emphasis on preserving haemostasis

Antiplatelet drugs are routinely used for the prevention and treatment of thrombosis, but also carry an inherent increased risk of bleeding. In this Review, McFadyen and colleagues assess the differences between thrombosis and haemostasis in the context of currently available antiplatelet drugs as well as novel antiplatelet agents that are entering preclinical and early-phase clinical testing.

James D. McFadyen
Mathieu Schaff
Karlheinz Peter
Reviews03 Jan 2018
Nature Reviews Cardiology

Volume: 15, P: 181-191
Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II

Klaus Schwarz and colleagues show that mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoetic anemia type II, a rare disease marked by defective cytokinesis in erythroblasts and membrane abnormalities in nucleated and peripheral red blood cells.

Klaus Schwarz
Achille Iolascon
Hermann Heimpel
Research28 Jun 2009
Nature Genetics

Volume: 41, P: 936-940
Particle generation, functionalization and sortase A–mediated modification with targeting of single-chain antibodies for diagnostic and therapeutic use

This protocol describes sortase A-mediated site-specific bioconjugation of single-chain antibodies to iron oxide particles for magnetic resonance imaging and to layer-by-layer capsules for drug delivery.

Christoph E Hagemeyer
Karen Alt
Karlheinz Peter
Protocols11 Dec 2014
Nature Protocols

Volume: 10, P: 90-105
Molecular magnetic resonance imaging of activated platelets allows noninvasive detection of early myocarditis in mice

Alexander Maier
Moritz Braig
Constantin von zur Mühlen
ResearchOpen Access06 Aug 2020
Scientific Reports

Volume: 10, P: 1-10
Distinct modulation of inactivation by a residue in the pore domain of voltage-gated Na⁺ channels: mechanistic insights from recent crystal structures

Rene Cervenka
Peter Lukacs
Hannes Todt
ResearchOpen Access12 Jan 2018
Scientific Reports

Volume: 8, P: 1-15
An activation specific anti-Mac-1 designed ankyrin repeat protein improves survival in a mouse model of acute lung injury

Patrick M. Siegel
Anne-Sophie Przewosnik
István Bojti
ResearchOpen Access15 Apr 2022
Scientific Reports

Volume: 12, P: 1-14
Subtractive single-chain antibody (scFv) phage-display: tailoring phage-display for high specificity against function-specific conformations of cell membrane molecules

Steffen U Eisenhardt
Meike Schwarz
Karlheinz Peter
Protocols21 Nov 2007
Nature Protocols

Volume: 2, P: 3063-3073
Dynamics of Heart Rate and Sleep Stages in Normals and Patients with Sleep Apnea

Thomas Penzel
Jan W Kantelhardt
Claus Vogelmeier
Research24 Jun 2003
Neuropsychopharmacology

Volume: 28, P: S48-S53

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