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Pre-existing immunity and vaccine history determine hemagglutinin-specific CD4 T cell and IgG response following seasonal influenza vaccination

Understanding individual variations in the response to seasonal influenza vaccines has broad implications from basic immunology to public health. Here authors show that influenza hemagglutinin-specific T and B cell responses are determined by the pre-vaccination immune phenotype and vaccination history of recipients.

Katharina Wild
Maike Smits
Tobias Boettler
ResearchOpen Access18 Nov 2021
Nature Communications

Volume: 12, P: 1-15
Rapid and stable mobilization of CD8⁺ T cells by SARS-CoV-2 mRNA vaccine

Longitudinal analyses of SARS-CoV-2 mRNA vaccine-elicited epitope-specific CD8⁺ T cell responses shows that CD8⁺ T cells are rapidly induced after prime vaccination and stably maintained after boost vaccination.

Valerie Oberhardt
Hendrik Luxenburger
Maike Hofmann
ResearchOpen Access28 Jul 2021
Nature

Volume: 597, P: 268-273
Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1⁺CD8⁺ T cells

Here the authors dissect the contribution of IL-21 signaling to immune checkpoint-responding CD8⁺ T cells from mouse models and patients being treated for advanced melanoma.

Zhen Zhang
Marlene Langenbach
Bertram Bengsch
Research19 Dec 2024
Nature Immunology

Volume: 26, P: 92-104

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