Nature Search

Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer

This study uses spatial proteomic and spatial compartment-based whole-transcriptome profiling to develop predictive models for immunotherapy outcomes in non-small cell lung cancer.

Thazin N. Aung
James Monkman
David L. Rimm
ResearchOpen Access10 Oct 2025
Nature Genetics

Volume: 57, P: 2482-2493
Genetic suppression features ABHD18 as a Barth syndrome therapeutic target

The enzyme ABHD18 is shown to have a key role in cardiolipin metabolism in mitochondria, offering a potential route for a small-molecule treatment of the rare genetic disease Barth syndrome.

Sanna N. Masud
Anchal Srivastava
Jason Moffat
Research03 Sept 2025
Nature

Volume: 645, P: 1029-1038
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses

A genome-wide meta-analysis of data from six US and European cohorts involving 1.3 million individuals identifies 243 genetic variants associated with risk and pathophysiology of depression, which is used to develop polygenic risk scores for the prediction of depression recurrence and comorbid psychiatric disorders.

Thomas D. Als
Mitja I. Kurki
Anders D. Børglum
Research18 Jul 2023
Nature Medicine

Volume: 29, P: 1832-1844
Quantification of rare allelic variants from pooled genomic DNA

The base-calling algorithm SNPSeeker detects single-nucleotide polymorphisms with frequencies that are below the error rate of the sequencing platform. It is thus well suited to analyze data from large pooled samples and find rare variants that may contribute to diseases or complex traits.

Todd E Druley
Francesco L M Vallania
Robi D Mitra
Research01 Mar 2009
Nature Methods

Volume: 6, P: 263-265
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Identification of common genetic risk variants for autism spectrum disorder

A genome-wide-association meta-analysis of 18,381 austim spectrum disorder (ASD) cases and 27,969 controls identifies five risk loci. The authors find quantitative and qualitative polygenic heterogeneity across ASD subtypes.

Jakob Grove
Stephan Ripke
Anders D. Børglum
Research25 Feb 2019
Nature Genetics

Volume: 51, P: 431-444
Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism

Anti-cancer fluoropyrimidine drugs have antibacterial effects on the gut microbiome, and these drugs can be metabolized by gut bacteria via conserved pathways also found in mammalian hosts.

Peter Spanogiannopoulos
Than S. Kyaw
Peter J. Turnbaugh
Research22 Sept 2022
Nature Microbiology

Volume: 7, P: 1605-1620
In Situ Breast Cancer and Microchimerism

Jinny K. Eun
Katherine A. Guthrie
V. K. Gadi
ResearchOpen Access12 Jul 2013
Scientific Reports

Volume: 3, P: 1-5
Can adult polygenic scores improve prediction of body mass index in childhood?

Katherine Lange
Jessica A. Kerr
Richard Saffery
Research03 May 2022
International Journal of Obesity

Volume: 46, P: 1375-1383
Cook and Move for Your Life, an eHealth intervention for women with breast cancer

Heather Greenlee
Eileen Rillamas-Sun
Nancy E. Davidson
ResearchOpen Access25 Jul 2024
npj Breast Cancer

Volume: 10, P: 1-8
The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control

Zeki Topcu
David L Mack
Katherine LB Borden
Research30 Nov 1999
Oncogene

Volume: 18, P: 7091-7100
Ketamine Treatment and Global Brain Connectivity in Major Depression

Chadi G Abdallah
Lynnette A Averill
James W Murrough
Research08 Sept 2016
Neuropsychopharmacology

Volume: 42, P: 1210-1219
Maternal microchimerism in healthy adults in lymphocytes, monocyte/macrophages and NK cells

Laurence S Loubière
Nathalie C Lambert
J Lee Nelson
Research11 Sept 2006
Laboratory Investigation

Volume: 86, P: 1185-1192

Search

Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer

Genetic suppression features ABHD18 as a Barth syndrome therapeutic target

Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses

Quantification of rare allelic variants from pooled genomic DNA

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Identification of common genetic risk variants for autism spectrum disorder

Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism

In Situ Breast Cancer and Microchimerism

Can adult polygenic scores improve prediction of body mass index in childhood?

Cook and Move for Your Life, an eHealth intervention for women with breast cancer

The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control

Ketamine Treatment and Global Brain Connectivity in Major Depression

Maternal microchimerism in healthy adults in lymphocytes, monocyte/macrophages and NK cells

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