Nature Search

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

TREM2 is an important AD risk factor playing essential roles in the microglial response to amyloid pathology. Here, authors show using a TREM2 reporter mouse that TREM2 levels are critical for efficacy of TREM2 agonism informing current clinical efforts.

Astrid F. Feiten
Kilian Dahm
Christian Haass
ResearchOpen Access24 Jan 2026
Nature Communications

P: 1-22
Severe and widespread coral reef damage during the 2014-2017 Global Coral Bleaching Event

From 2014–2017, marine heatwaves caused global mass coral bleaching, where the corals lose their symbiotic algae. The authors find, this event exceeded the severity of all prior global bleaching events in recorded history, with approximately half the world’s reefs bleaching and 15% experiencing substantial mortality.

C. Mark Eakin
Scott F. Heron
Derek P. Manzello
ResearchOpen Access10 Feb 2026
Nature Communications

Volume: 17, P: 1-14
Biochemical, Morphologic, and Gytogenetic Studies of Leukocytes Growing in Continuous Culture from Normal Individuals and from Patients with Cystinosis

Joseph D Schulman
Kathryn H Bradley
Matti S Al-Aish
Research01 Oct 1971
Pediatric Research

Volume: 5, P: 501-510
Therapeutic targeting of neuroimmune mechanisms in neurodegeneration

Neuroimmune interactions shape neurodegenerative disease progression. This Review examines how microglia integrate signals from central and peripheral immune cells, outlines emerging therapeutic targets beyond core pathology, and discusses the growing need for immune-based biomarkers in Alzheimer’s disease and related disorders.

Kathryn M. Monroe
Soyon Hong
Andrew C. Yang
Reviews16 Feb 2026
Nature Reviews Drug Discovery

P: 1-16
A Lassa virus mRNA vaccine confers protection but does not require neutralizing antibody in a guinea pig model of infection

Lassa virus infections in humans can result in severe disease, including hemorrhagic fever. Here the authors describe an mRNA-based Lassa virus vaccine that shows protection without requirement for neutralizing antibody in a guinea pig model of infection.

Adam J. Ronk
Nicole M. Lloyd
Alexander Bukreyev
ResearchOpen Access12 Sept 2023
Nature Communications

Volume: 14, P: 1-13
Correction: Corrigendum: Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

Gilad Doitsh
Nicole L. K. Galloway
Warner C. Greene
Amendments and Corrections22 Mar 2017
Nature

Volume: 544, P: 124
A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models

van Lengerich et al. developed a human TREM2 antibody with a transport vehicle (ATV) that improves brain exposure and biodistribution in mouse models. ATV:TREM2 promotes microglial energetic capacity and metabolism via mitochondrial pathways.

Bettina van Lengerich
Lihong Zhan
Kathryn M. Monroe
ResearchOpen Access12 Jan 2023
Nature Neuroscience

Volume: 26, P: 416-429
Strontium isoscape of sub-Saharan Africa allows tracing origins of victims of the transatlantic slave trade

Strontium isotope analysis can be applied to animal and plant tissues to help determine their provenance. Here, the authors generate a strontium isoscape of sub-Saharan Africa using data from 2266 environmental samples and demonstrate its efficacy by tracing the African roots of individuals from historic slavery contexts.

Xueye Wang
Gaëlle Bocksberger
Vicky M. Oelze
ResearchOpen Access30 Dec 2024
Nature Communications

Volume: 15, P: 1-14
Author Correction: Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination

Mar Bosch-Queralt
Ludovico Cantuti-Castelvetri
Mikael Simons
Amendments and Corrections23 Feb 2023
Nature Metabolism

Volume: 5, P: 531
STING is a direct innate immune sensor of cyclic di-GMP

Dara L. Burdette
Kathryn M. Monroe
Russell E. Vance
Research25 Sept 2011
Nature

Volume: 478, P: 515-518
Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination

Bosch-Queralt et al. find that diet-induced obesity impairs restoration of CNS demyelination through increased TGFβ-mediated suppression of cholesterol efflux.

Mar Bosch-Queralt
Ludovico Cantuti-Castelvetri
Mikael Simons
Research18 Feb 2021
Nature Metabolism

Volume: 3, P: 211-227
Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia

Andreone, Przybyla et al. used induced pluripotent stem cell-derived human microglia to show that TREM2-dependent phagocytosis and lipid metabolism require the Alzheimer’s risk factor PLCγ2, which can also mediate TREM2-independent inflammatory signaling via Toll-like receptors.

Benjamin J. Andreone
Laralynne Przybyla
Joseph W. Lewcock
Research08 Jun 2020
Nature Neuroscience

Volume: 23, P: 927-938
CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Chromodomain Helicase DNA-binding (CHD) proteins have been implicated in neurodevelopmental processes. Here, the authors identify missense variants in CHD3 that disturb its chromatin remodeling activities and cause a neurodevelopmental disorder with macrocephaly and speech and language impairment.

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
ResearchOpen Access05 Nov 2018
Nature Communications

Volume: 9, P: 1-12
Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

Quiescent CD4 T cells in lymphoid tissues are shown to die after HIV-1 infection by caspase-1-mediated pyroptosis, a highly inflammatory form of programmed cell death; caspase 1 inhibitors, which are safe for human use, can rescue the cell death in vitro raising the possibility of new therapeutics targeting the host instead of the virus.

Gilad Doitsh
Nicole L. K. Galloway
Warner C. Greene
Research19 Dec 2013
Nature

Volume: 505, P: 509-514
Understanding COVID-19 through human challenge models

As the pandemic evolves, questions remain but field studies are increasingly difficult; if carefully designed, human challenge models could offer a practical and timely solution.

Kathryn M. Edwards
Kathleen M. Neuzil
News & Views31 Mar 2022
Nature Medicine

Volume: 28, P: 903-904
Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
Amendments and CorrectionsOpen Access15 Feb 2019
Nature Communications

Volume: 10, P: 1-4
Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
Amendments and CorrectionsOpen Access02 May 2019
Nature Communications

Volume: 10, P: 1-4
Microglia clean up toxic lipids in multiple sclerosis

Dong and colleagues investigated mechanisms mediating neurodegeneration in multiple sclerosis and identified a direct role for oxidized phosphatidylcholines (OxPCs) in driving CNS cell death. Microglia activity, mediated by the lipid sensor TREM2 and a neutralizing OxPC antibody, were capable of rescuing OxPC-induced neurotoxicity.

Kathryn M. Monroe
Gilbert Di Paolo
News & Views23 Mar 2021
Nature Neuroscience

Volume: 24, P: 451-452
Francisella tularensis novicida infection competence differs in cell lines derived from United States populations of Dermacentor andersoni and Ixodes scapularis

Kathryn E. Reif
Jessica K. Ujczo
Susan M. Noh
ResearchOpen Access23 Aug 2018
Scientific Reports

Volume: 8, P: 1-10
Cognitive assessment in the Accelerating Medicines Partnership® Schizophrenia Program: harmonization priorities and strategies in a diverse international sample

Kelly Allott
Walid Yassin
William S. Stone
ResearchOpen Access24 Mar 2025
Schizophrenia

Volume: 11, P: 1-12
Consistently processed RNA sequencing data from 50 sources enriched for pediatric data

Holly C. Beale
Katrina Learned
Olena M. Vaske
ResearchOpen Access02 Jul 2025
Scientific Data

Volume: 12, P: 1-10
Evaluation of the economic impact of modified screening criteria for retinopathy of prematurity from the Postnatal Growth and ROP (G-ROP) study

John A. F. Zupancic
Gui-shuang Ying
Gui-shuang Ying
Research28 Feb 2020
Journal of Perinatology

Volume: 40, P: 1100-1108

Search

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

Severe and widespread coral reef damage during the 2014-2017 Global Coral Bleaching Event

Biochemical, Morphologic, and Gytogenetic Studies of Leukocytes Growing in Continuous Culture from Normal Individuals and from Patients with Cystinosis

Therapeutic targeting of neuroimmune mechanisms in neurodegeneration

A Lassa virus mRNA vaccine confers protection but does not require neutralizing antibody in a guinea pig model of infection

Correction: Corrigendum: Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models

Strontium isoscape of sub-Saharan Africa allows tracing origins of victims of the transatlantic slave trade

Author Correction: Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination

STING is a direct innate immune sensor of cyclic di-GMP

Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination

Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia

CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

Understanding COVID-19 through human challenge models

Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Microglia clean up toxic lipids in multiple sclerosis

Francisella tularensis novicida infection competence differs in cell lines derived from United States populations of Dermacentor andersoni and Ixodes scapularis

Cognitive assessment in the Accelerating Medicines Partnership® Schizophrenia Program: harmonization priorities and strategies in a diverse international sample

Consistently processed RNA sequencing data from 50 sources enriched for pediatric data

Evaluation of the economic impact of modified screening criteria for retinopathy of prematurity from the Postnatal Growth and ROP (G-ROP) study

Search

Quick links

Search

Filter By:

Search

Quick links