Endothelial-to-mesenchymal transition (EndoMT) is critical for the formation of the cardiac valves and contributes postnatally to the development of cardiovascular diseases. However, progress in lineage-tracing technology has challenged the role of EndoMT in cardiac fibrosis. In this Review, Li and colleagues discuss the caveats of using lineage tracing to investigate cell-lineage conversion and reassess the role of EndoMT in cardiovascular development and diseases.
- Yan Li
- Kathy O. Lui
- Bin Zhou
