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Pronobis et al. show that Ddx61 localizes to P-bodies and regulates heart muscle proliferation during cardiac regeneration in zebrafish. Ddx61 is required is required to restrain expression of Chordin, a secreted BMP inhibitor that impedes regeneration if present at high levels.

White adipose tissue (WAT) dysfunction leads to ageing-related metabolic disorders. Here, the authors show that the FMO3-TMAO axis in adipocytes induces senescence and inflammation in WAT microenvironment via NLRP3 inflammasome, leading to systemic glucose, lipid, and energy dysregulation in ageing

Weakly electric fish species use low-voltage to sense their surroundings, whereas a few strongly electric species use high-voltage as a weapon. Here the author shows that electric eels cross this boundary, using high-voltage simultaneously as a stunning weapon and as an electrical radar system to track fast-moving prey.

The rate of scale regeneration in zebrafish is controlled by the frequency of rhythmic travelling waves of Erk activity, which are broadcast from a central source to induce ring-like patterns of osteoblast tissue growth.

The authors compared mRNA expression in a closed system real-time quantitative reverse transcription PCR assay for key breast cancer markers in non-micro-dissected tissue versus micro-dissected tissue in both invasive and ductal carcinoma in situ breast cancer cohorts. They found that microdissection of whole sections is not required for concordance with immunohistochemistry and fluorescence in situ hybridization.

Depth of response (CR/VGPR, MRD-) links to better outcomes, while biochemical progression predicts end-organ damage. Higher MHC-I on tumors and greater GZMB+ T cells in clonally expanded CD8+ T cells are tied to improved outcomes.

The number of individuals in a given space influences animal interactions and network dynamics. Here the authors identify general rules underlying density dependence in animal networks and reveal some fundamental differences between spatial and social dynamics.

Entacapone, a Parkinson’s disease medication, sequesters iron resulting in a selective inhibition of gut microbial activity.

Sun et al. report that a steroid-responsive enhancer is preferentially required for expression and function of cebpd in remote tissues during heart regeneration.

A connectome of the right optic lobe from a male fruitfly is presented together with an extensive collection of genetic drivers matched to a comprehensive neuron-type catalogue.

FISHnet is a graph-theory-based method for sensitive and specific identification of 3D genome features in sequential Oligopaints data.

Mice models often fail to reflect human telomere biology. Here, the authors engineer a mouse strain with a humanized mTert gene, restoring telomere length regulation to a human-like pattern. This model might provide insights into aging and cancer.

Lightning Pose is an efficient pose estimation approach that requires few labeled training data owing to its semi-supervised learning strategy and ensembling.

Olfactory neuroblastoma (ONB) is a rare malignant tumor whose genetic basis is poorly understood. Here the authors identify recurrent deletions involving dystrophin in the majority of ONB patient tumors examined.

Zebrafish can regenerate after paralyzing spine injuries and regain locomotor ability, unlike mammals. Here authors show that the neurogenic factor Hb-egf promotes spinal cord regeneration in zebrafish and is regulated by an enhancer that can similarly direct expression in the pro-regenerative setting of neonatal mice.

After acute agonist stimulation, phase-separated complexes form at estrogen-receptor-bound enhancer sites and coalesce into condensates with cooperative enhancer activity. Chronic stimulation causes the condensates to mature into a less dynamic, gel-like state.

Cloutier et al. discover that human embryonic stem cells (hESCs) cultured with media containing inhibitors of GSK3 proteins undergo erosion of X-chromosome inactivation, which equalizes X-linked gene expression between females and males. The findings inform the faithful culture of hESCs.

Accurate, spatiotemporally resolved monitoring of environments and ecosystems serves as the starting point to both identify and remedy natural or anthropogenic environmental hazards. This Review covers materials science advances supporting a new paradigm in environmental sensing: distributed networks of sensing elements capable of system-level profiling with the possibility of harmless environmental resorption after a predetermined recording period.

Biallelic loss-of-function variants in FOCAD cause a syndromic form of pediatric liver disease by compromising the SKI messenger RNA surveillance pathway.

A study of zebrafish identifies an innate mechanism of blood vessel formation through the transdifferentiation of lymphatic endothelial cells, and provides in vivo evidence for a link between cell ontogeny and functionality in endothelial cells.

Little is known about certain bacterial phyla because of our current inability to grow them in the lab. Here, Luef et al.combine metagenomics and ultrastuctural analyses to show that some of these bacteria have a very small cell size, tightly packed DNA, few ribosomes and diverse pili-like structures.

Eberhardt et al. show that SARS-CoV-2 infects human coronary lesions where it preferentially targets plaque macrophages, triggering plaque inflammation and potentially leading to acute cardiovascular complications and long-term cardiovascular risks in patients with COVID-19.

The natural progression of tumours and their treatment can influence tumour evolution. Here, authors analyse whole-exome sequencing data from various cancer cohorts, finding that treatment-resistant tumors shift toward neutral evolution, which correlates with worse prognosis, and monitoring this shift may guide treatment decisions.

Reduced fitness of the tumor microenvironment is mediated by a long non-coding RNA expressed in tumors.

A genome-wide screen has identified a frequent region of amplification on chromosome 5p13 in a number of cancer types. Functional studies now identify a protein localized to the Golgi apparatus, GOLPH3, as a novel oncogene affected by this amplification which can transform cells in vitro and lead to tumour formation in vivo. GOLPH3 overexpression activates the mTOR signalling pathway and renders cancer cells sensitive to the drug rapamycin.

Artificial reefs provide important ecosystem services in marine environments. Accurate knowledge of the area covered by such reefs can help evaluate benefits and risks of such structures. This study describes the physical footprint of artificial reefs deployed in coastal waters of the United States.

Using microcosms, stable isotope probing, genome-resolved metagenomics and NanoSIMS, the authors identify diverse bacterial taxa that can degrade extracellular DNA in marine sediments, including ‘Candidatus Izemoplasma’, which encode numerous extracellular nucleases.

An injury-dependent enhancer element is identified that activates gene expression in regenerating zebrafish tissues and can be engineered into DNA constructs that increase tissue regenerative capacity; the element is also active in injured mouse tissue.