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Showing 1–8 of 8 results
Advanced filters: Author: Kenneth Paigen Clear advanced filters

  • This article describes the important advances in our understanding of recombination in humans and mice, from the properties and activity of individual hot spots to the control of the recombination landscape along chromosomes and between the sexes.

    • Kenneth Paigen
    • Petko Petkov
    Reviews
    Nature Reviews Genetics
    Volume: 11, P: 221-233

  • The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse resources that are optimized to study the actions of isolated genetic loci on a fixed background are less effective for studying intact polygenic networks and interactions among genes, environments, pathogens and other factors. The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease.

    • Gary A Churchill
    • David C Airey
    • Fei Zou
    Comments & Opinion
    Nature Genetics
    Volume: 36, P: 1133-1137

  • The laboratories of Galina Petukhova and R Daniel Camerini-Otero have achieved significant technical advances in determining the genome-wide sites of DNA double-strand breaks (DSBs) where the process of genetic exchange between chromatids during meiosis begins. Applying the new approaches to male meiosis in mice, their experimental results considerably increase our insights into the nature and regulation of these processes.

    • Kenneth Paigen
    • Petko Petkov
    Research Highlights
    Cell Research
    Volume: 22, P: 1624-1626

  • Systems biology harnesses experimental and computational high-throughput techniques to unravel complex biological interactions, such as those between genetic and environmental factors. Drs MacLellan, Wang, and Lusis provide an overview of system-based approaches to cardiovascular diseases and discuss the translational implications of such studies.

    • W. Robb MacLellan
    • Yibin Wang
    • Aldons J. Lusis
    Reviews
    Nature Reviews Cardiology
    Volume: 9, P: 172-184