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Showing 1–4 of 4 results
Advanced filters: Author: Keren Reshef Clear advanced filters

  • Elyahu and colleagues describe the reciprocal interplay between senescent cells (SCs) and a helper T cell population that accumulates during aging. They show that selective depletion of this T cell population increases SC accumulation, accelerates frailty and limits lifespan in mice.

    • Yehezqel Elyahu
    • Ilana Feygin
    • Alon Monsonego
    Research
    Nature Aging
    Volume: 5, P: 1970-1982

  • Chronic UV exposure has been associated with immune system suppression. Here the authors show that enhanced tumor growth and resistance to PD1 blockade in mice exposed to UV irradiation is associated with induced expression of Ly6a in CD8 + T cells and that targeting Ly6a enhances anti-tumor immune responses in models resistant to anti-PD1.

    • Avishai Maliah
    • Nadine Santana-Magal
    • Carmit Levy
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • An Escherichia coli-based genetic selection system, constructed from a split antibiotic resistance protein individually tethered to ubiquitin and a target protein, helps discover ubiquitin cascade pathway interactions.

    • Olga Levin-Kravets
    • Neta Tanner
    • Gali Prag
    Research
    Nature Methods
    Volume: 13, P: 945-952