This study identifies the conversion of lysine to Δ1-piperideine-6-carboxylic acid (P6C) via pipecolate oxidase as a conserved pathway in plants and humans. P6C interacts with vitamin B6, affecting its homeostasis. Imbalances in vitamin B6 homeostasis disrupt defence in plants and cause neuropathology in humans.
- Huazhen Liu
- Lakshminarayan M. Iyer
- Pradeep Kachroo