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Showing 1–12 of 12 results
Advanced filters: Author: Kevin Ciminski Clear advanced filters

  • A comparison of the repertoire of SARS-CoV-2-specific epitopes targeted by T cells induced by vaccination or natural infection reveals that T cells predominantly target non-spike epitopes in convalescent individuals, while there is a broader spike-specific CD8+ T-cell response in vaccinees. Despite differences in T-cell response, the targeted T-cell epitopes were conserved between the wild-type and Omicron variants in both groups.

    • Julia Lang-Meli
    • Hendrik Luxenburger
    • Christoph Neumann-Haefelin
    ResearchOpen Access
    Nature Microbiology
    Volume: 7, P: 675-679

  • In this study, the authors report that bat H9N2 influenza A virus replicates and transmits in ferrets, efficiently infects human lung explant cultures, evades MxA antiviral activity in mice, and has low antigenic similarity to seasonal N2, meeting pre-pandemic criteria.

    • Nico Joel Halwe
    • Lea Hamberger
    • Martin Beer
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-8

  • Vaccines induce beneficial immunity for COVID-19, but immune waning prompts boosting vaccination. Here, the authors show that a third, boosting dose of COVID-19 mRNA vaccine induces transient CD8 + T effector cell response while conserving the CD8 memory T cell pool, thereby permitting reactivation of spike-specific CD8 + T cells upon breakthrough infection or 4th vaccination.

    • Matthias Reinscheid
    • Hendrik Luxenburger
    • Maike Hofmann
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • The global outbreak of H5N1 highly pathogenic avian influenza virus and its high toll on animal populations raise concerns about spillover into humans, but human host barriers need to be considered when estimating transmission potential.

    • Kevin Ciminski
    • Geoffrey Chase
    • Martin Beer
    Comments & Opinion
    Nature Microbiology
    Volume: 8, P: 1603-1605

  • During viral infections high levels of antibodies can form soluble immune complexes (sICs) with antigen and trigger Fcγ receptors (FcγR) leading to increased immunopathology. Here the authors measure FcγRs activation by sICs and consider how these may lead to excessive immunopathology during severe SARS-CoV-2 infection.

    • Jakob Ankerhold
    • Sebastian Giese
    • Valeria Falcone
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Longitudinal analyses of SARS-CoV-2 mRNA vaccine-elicited epitope-specific CD8+ T cell responses shows that CD8+ T cells are rapidly induced after prime vaccination and stably maintained after boost vaccination.

    • Valerie Oberhardt
    • Hendrik Luxenburger
    • Maike Hofmann
    ResearchOpen Access
    Nature
    Volume: 597, P: 268-273

  • Analysis of the genetic stability and replication potential of bat H18N11 influenza A viruses reveals that they are poorly adapted to ferrets and mice and that they transmit among bats only in presence of the full-length neuraminidase-like protein N11.

    • Kevin Ciminski
    • Wei Ran
    • Martin Schwemmle
    Research
    Nature Microbiology
    Volume: 4, P: 2298-2309

  • Post-translational modifications of influenza A virus proteins can regulate virus replication, but the effect of nucleoprotein (NP) acetylation is not known. Here, Giese et al. identify four NP lysine residues that are acetylated in infected cells and study their role in polymerase activity and virion release.

    • Sebastian Giese
    • Kevin Ciminski
    • Martin Schwemmle
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11