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Showing 1–3 of 3 results
Advanced filters: Author: Kevin F. Bieniek Clear advanced filters

  • Alzheimer’s disease disrupts brain lipid metabolism; while microglia are likely implicated, the relationship is unclear. Here, the authors show that microglia selectively regulate lysosomal and myelin lipids, but other lipid changes occur independently of microglia.

    • Ziying Xu
    • Sepideh Kiani Shabestari
    • Xianlin Han
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Here the authors identify TNIP1 as a risk factor for a fatal neurodegenerative disorder and discover specific genetic loci associated with the three main subtypes of this disorder. The findings highlight distinct disease mechanisms, emphasizing the roles of immunity and the notch signaling pathway.

    • Cyril Pottier
    • Fahri Küçükali
    • Rosa Rademakers
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Evidence suggests that aberrant RNA processing contributes to amyotrophic lateral sclerosis (ALS). Using RNA sequencing, Prudencio et al. assessed the extent of transcriptome defects in C9orf72-associated (c9ALS) and sporadic ALS (sALS) brains. They report extensive defects in expression, alternative splicing and alternative polyadenylation that are significantly distinct between individuals with c9ALS and sALS.

    • Mercedes Prudencio
    • Veronique V Belzil
    • Leonard Petrucelli
    Research
    Nature Neuroscience
    Volume: 18, P: 1175-1182