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Showing 1–50 of 100 results
Advanced filters: Author: Kevin Kit Parker Clear advanced filters
  • Immunotherapy has yet to demonstrate efficacy for patients with glioblastoma. Here, the authors employ human single-cell RNA-seq, spatial transcriptomics, and a preclinical mouse model to show that glioblastoma cell-derived synaptogenic factor Thrombospondin-1 promotes neuronal circuit remodeling and regional immunosuppression, highlighting a potential therapeutic target.

    • Takahide Nejo
    • Saritha Krishna
    • Hideho Okada
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19
  • N-terminal acetylation dysregulation in the heart causes severe arrhythmia and cardiomyopathy. The authors show that stem cell models demonstrate ion channel trafficking defects and sarcomeric disarray as the underlying mechanisms, with gene therapy reversing both phenotypes

    • Daisuke Yoshinaga
    • Isabel Craven
    • Vassilios J. Bezzerides
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-23
  • Genome-wide CRISPR screens, biochemical studies and animal models show that RASA2 has a key role in regulating T cell function and has potential as a genetic target for enhancing anti-tumour immunity.

    • Julia Carnevale
    • Eric Shifrut
    • Alexander Marson
    ResearchOpen Access
    Nature
    Volume: 609, P: 174-182
  • Effective anti-PD-1 immunotherapy is associated with the presence of polyclonal CD8+ T cells in the tumour and blood specific for a limited number of immunodominant mutations, which are recurrently recognized over time.

    • Cristina Puig-Saus
    • Barbara Sennino
    • Antoni Ribas
    Research
    Nature
    Volume: 615, P: 697-704
  • Multi-modal analysis of genomically unstable ovarian tumours characterizes the contribution of anatomical sites and mutational processes to evolutionary phenotypic divergence and immune resistance mechanisms.

    • Ignacio Vázquez-García
    • Florian Uhlitz
    • Sohrab P. Shah
    ResearchOpen Access
    Nature
    Volume: 612, P: 778-786
  • Profiling the immune responses of 56 volunteers vaccinated with BNT162b2 reveals how this mRNA vaccine primes the innate immune system to mount a potent response to SARS-CoV-2 after booster immunization.

    • Prabhu S. Arunachalam
    • Madeleine K. D. Scott
    • Bali Pulendran
    Research
    Nature
    Volume: 596, P: 410-416
  • T cell activation is a process that requires extra nutrients, which could be difficult to source from the tumor microenvironment in competition with tumor cells. Here authors increase the metabolic fitness of CAR-T cells by stable overexpression of the glucose transporter GLUT1, which allows them to increase their glucose intake and enhances their antitumour function.

    • Justin A. Guerrero
    • Dorota D. Klysz
    • Crystal L. Mackall
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20
  • Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

    • Joshua S. Weinstock
    • Jayakrishnan Gopakumar
    • Siddhartha Jaiswal
    Research
    Nature
    Volume: 616, P: 755-763
  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103
  • Combination of epidemiology, preclinical models and ultradeep DNA profiling of clinical cohorts unpicks the inflammatory mechanism by which air pollution promotes lung cancer

    • William Hill
    • Emilia L. Lim
    • Charles Swanton
    Research
    Nature
    Volume: 616, P: 159-167
  • The upcycling of protein materials has been hindered by the difficulty in restructuring them to usable forms. Here, the authors reveal that concentrated ion pairs like LiBr disrupt the water network structure rather than directly interacting with proteins, and develop a sustainable keratin regeneration method with closed-loop recycling of ionic denaturant and rapid solidification of protein gels.

    • Yichong Wang
    • Junlang Liu
    • Eugene I. Shakhnovich
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • A phase I clinical trial of an adjuvant personalized mRNA neoantigen vaccine, autogene cevumeran, in patients with pancreatic ductal carcinoma demonstrates that the vaccine can induce T cell activity that may correlate with delayed recurrence of disease.

    • Luis A. Rojas
    • Zachary Sethna
    • Vinod P. Balachandran
    ResearchOpen Access
    Nature
    Volume: 618, P: 144-150
  • Here Ramanan and colleagues provide an analysis of mammary T cells during late pregnancy and lactation. This revealed an increase in intraepithelial lymphocytes in the lactating mammary gland, which was driven by thymic and intestinal inputs and was sensitive to changes in the microbiota

    • Abigail Jaquish
    • Eleni Phung
    • Deepshika Ramanan
    Research
    Nature Immunology
    Volume: 26, P: 1411-1422
  • The X-ray structure of the hexameric complex of interferon-γ bound to its receptors is solved at 3.25 Å resolution, providing a basis for engineering variants of interferon-γ that enable decoupling of its immunomodulatory functions.

    • Juan L. Mendoza
    • Nichole K. Escalante
    • K. Christopher Garcia
    Research
    Nature
    Volume: 567, P: 56-60
  • The viral delivery of a miniaturized form of a master protein that establishes dyads (nanostructures involved in excitation–contraction coupling in cardiomyocytes) improved dyad architecture and normalized cardiac function under pressure overload.

    • Fujian Lu
    • Carter Liou
    • William T. Pu
    Research
    Nature Biomedical Engineering
    Volume: 9, P: 730-741
  • T cells containing an anti-mesothelin single-domain antibody fused to a component of the endogenous T cell receptor signaling complex exhibit notable toxicities but encouraging clinical responses in patients with treatment-refractory mesothelioma and ovarian cancer.

    • Raffit Hassan
    • Marcus Butler
    • David Hong
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 2099-2109
  • During an ongoing Ebola virus outbreak, infection before onset of protective immunity from vaccination is a possible scenario. Here the authors show in non-human primates that vaccination shortly before treatment with a monoclonal antibody does not negatively affect effectiveness of the antibody therapy.

    • Robert W. Cross
    • Zachary A. Bornholdt
    • Thomas W. Geisbert
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8
  • Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

    • James E. D. Thaventhiran
    • Hana Lango Allen
    • Kenneth G. C. Smith
    Research
    Nature
    Volume: 583, P: 90-95
  • The Omicron variant evades vaccine-induced neutralization but also fails to form syncytia, shows reduced replication in human lung cells and preferentially uses a TMPRSS2-independent cell entry pathway, which may contribute to enhanced replication in cells of the upper airway. Altered fusion and cell entry characteristics are linked to distinct regions of the Omicron spike protein.

    • Brian J. Willett
    • Joe Grove
    • Emma C. Thomson
    ResearchOpen Access
    Nature Microbiology
    Volume: 7, P: 1161-1179
  • The peptidergic neuronal circuit controlling sigh generation has been identified as ~200 Nmb- or Grp-expressing neurons in the RTN/pFRG breathing control centre of the medulla that project to ~200 receptor-expressing neurons in the respiratory rhythm generator, the preBötzinger Complex.

    • Peng Li
    • Wiktor A. Janczewski
    • Jack L. Feldman
    Research
    Nature
    Volume: 530, P: 293-297
  • A system employing liquid-handling robotics and an integrated mobile microscope enables the automated culture, sample collection and in situ microscopy imaging of up to ten fluidically coupled organ chips within a standard tissue-culture incubator.

    • Richard Novak
    • Miles Ingram
    • Donald E. Ingber
    Research
    Nature Biomedical Engineering
    Volume: 4, P: 407-420
  • The heterogeneity of androgen receptor (AR) gene alterations across metastases in prostate cancer remains unresolved. Here, the authors characterise AR genomic complexity across spatially separated lethal metastases from 10 prostate cancer patients and investigate how AR alterations evolve.

    • A. M. Mahedi Hasan
    • Paolo Cremaschi
    • Gerhardt Attard
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16
  • The myeloma cell surface proteome regulates plasma cell biology and delineates therapy targets. Here, the authors profile the myeloma surfaceome at baseline and in drug resistance, finding the potential target CCR10, and include a streamlined approach to primary sample analysis.

    • Ian D. Ferguson
    • Bonell Patiño-Escobar
    • Arun P. Wiita
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17
  • A study reveals that activation of Toll/interleukin-1 receptor signalling is an important mechanism for boosting plant defence during pattern-triggered immunity.

    • Hainan Tian
    • Zhongshou Wu
    • Yuelin Zhang
    Research
    Nature
    Volume: 598, P: 500-503
  • Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

    • Steven A. Kemp
    • Dami A. Collier
    • Ravindra K. Gupta
    Research
    Nature
    Volume: 592, P: 277-282
  • Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

    • Dami A. Collier
    • Anna De Marco
    • Ravindra K. Gupta
    Research
    Nature
    Volume: 593, P: 136-141
  • In this work, authors assess airway microbiome dynamics to show bacterial pneumonia in critically ill COVID-19 patients is significantly associated with death, corticosteroid treatment, disruption of the lung microbiome and a distinct pulmonary host response.

    • Natasha Spottiswoode
    • Alexandra Tsitsiklis
    • Charles R. Langelier
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16
  • In a phase 1 trial, patients with pancreatic ductal adenocarcinoma who were treated with surgery and bespoke neoantigen mRNA vaccines combined with anti-PD-L1 and chemotherapy exhibited marked long-lived persistence of neoantigen-specific CD8+ T cell clones, which correlated with prolonged recurrence-free survival at a 3.2-year follow-up.

    • Zachary Sethna
    • Pablo Guasp
    • Vinod P. Balachandran
    ResearchOpen Access
    Nature
    Volume: 639, P: 1042-1051
  • Dexamethasone has been used in the treatment of critically ill COVID-19 patients. Here the authors apply transcriptomics to investigate the effects of dexamethasone treatment in COVID-19 patients, and show both systemic and compartment-specific effects.

    • Lucile P. A. Neyton
    • Ravi K. Patel
    • Gabriela K. Fragiadakis
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14
  • Cardiomyocytes generated from induced pluripotent cells hold great promise for understanding and treating heart disease. William Pu and his colleagues apply new technologies for studying such cardiomyocytes from patients with Barth syndrome to explore how the mitochondrial defects characteristic of this syndrome lead to heart dysfunction.

    • Gang Wang
    • Megan L McCain
    • William T Pu
    Research
    Nature Medicine
    Volume: 20, P: 616-623
  • The variability in synaptic connectivity observed at the cerebellar granule cell - Purkinje cell connection in mice accounts for motor behavior traits at the individual level, suggesting that cerebellar networks encode internal models underlying individual-specific motor adaptation.

    • Ludovic Spaeth
    • Jyotika Bahuguna
    • Philippe Isope
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19
  • Here, the authors perform transcriptional profiling on tracheal aspirates of adults requiring mechanical ventilation for SARS-CoV2-induced acute respiratory distress syndrome (ARDS) and identify a dysregulated host response predicted to predicted to be potentially modulated by dexamethasone.

    • Aartik Sarma
    • Stephanie A. Christenson
    • Charles R. Langelier
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10
  • Multiomic profiling of several cohorts of patients treated with immune checkpoint blockade highlights the presence and potential role of B cells and tertiary lymphoid structures in promoting therapy response.

    • Beth A. Helmink
    • Sangeetha M. Reddy
    • Jennifer A. Wargo
    Research
    Nature
    Volume: 577, P: 549-555