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Showing 1–3 of 3 results
Advanced filters: Author: Kirti Pai Clear advanced filters

  • Nephropathy is a common and hard-to-treat consequence of diabetes. Here Kato et al. show that a megacluster of microRNAs regulates early development of diabetic nephropathy in mice, and that inhibition of the cluster's host long non-coding RNA transcript attenuates disease symptoms, suggesting a new therapy for diabetic nephropathy.

    • Mitsuo Kato
    • Mei Wang
    • Rama Natarajan
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-16

  • Hepatocellular carcinoma (HCC) is the fifth most commonly occurring cancer and the third most common cause of cancer-related deaths, and the incidence of this cancer is increasing. A substantial portion of HCCs are thought to arise from hepatic stem cells. In this Review, Lopa Mishra and colleagues describe TGF-β signalling in liver stem cell niches, and examine the roles of this cytokine including those in tumour progression and suppression. Important translational studies that are needed to develop novel therapies are discussed.

    • Avijit Majumdar
    • Steven A. Curley
    • Lopa Mishra
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 9, P: 530-538