Peptidoglycan recognition proteins (PGLYRPs) are implicated in the control of the intestinal microbiota. Here, combining in vitro and in vivo work, the authors show that PGLYRP-1 act as an intracellular pattern recognition receptor for the detection of peptidoglycan disaccharides that regulate host defense responses in the intestine.
- Shuyuan Chen
- Rachel Putnik
- Hans-Christian Reinecker
