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Showing 1–4 of 4 results
Advanced filters: Author: Kohl Swift Clear advanced filters
  • Several persistent challenges limit the efficacy and applicability of adoptive T cell therapies for cancer, including suboptimal function and/or persistence in vivo, a narrow range of targetable antigens and complex manufacturing processes. This Review discusses the potential of ‘CRISPR 2.0’ precision gene-editing platforms, such as base editing and prime editing to address all of these challenges, and describes the progress made towards clinical translation of these technologies.

    • Karl Petri
    • Elvira D’Ippolito
    • Michael Hudecek
    Reviews
    Nature Reviews Clinical Oncology
    P: 1-22
  • The focus of cardiovascular research has changed over the decades, and non-myocytes, including fibroblasts, are becoming increasingly central to our understanding of cardiac function. Kohl and colleagues discuss cardiac fibroblasts, their origins and their expanding roles in homeostasis and tissue repair, and highlight opportunities for therapeutic intervention.

    • Robert G. Gourdie
    • Stefanie Dimmeler
    • Peter Kohl
    Reviews
    Nature Reviews Drug Discovery
    Volume: 15, P: 620-638
  • Absence seizures impair consciousness by an unknown neuronal mechanism. Here, the authors find that a rat absence seizure model’s behavior and hemodynamics recapitulate previously reported characteristics of human absence seizures, and uncover four distinct patterns of neuronal activity in cortex and thalamus during consciousness-impairing seizures.

    • Cian McCafferty
    • Benjamin F. Gruenbaum
    • Hal Blumenfeld
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19