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Showing 1–4 of 4 results
Advanced filters: Author: Kristiyan Kanev Clear advanced filters

  • Single-cell RNA-seq offers the opportunity to improve efficacy of T-cell based immunotherapy. Here the authors develop a plate-based method for cytotoxic T cell profiling. It captures a higher number of transcripts and detects gene with increased dynamic range in comparison to droplet-based methods.

    • Kristiyan Kanev
    • Patrick Roelli
    • Dietmar Zehn
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Here the authors show that dihydroorotate dehydrogenase in the de novo pyrimidine synthesis pathway functions as a cell fate checkpoint that can be targeted to specifically diminish the number and function of effector T cells without affecting the memory T cell pool and response to infection.

    • Stefanie Scherer
    • Susanne G. Oberle
    • Dietmar Zehn
    Research
    Nature Immunology
    Volume: 24, P: 501-515

  • Scellnetor is a single-cell network enrichment method that can unravel connected molecular interaction networks to explain the progression and differentiation of developmental trajectories on a systems biology level.

    • Alexander G. B. Grønning
    • Mhaned Oubounyt
    • Jan Baumbach
    Research
    Nature Computational Science
    Volume: 1, P: 153-163