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Showing 1–4 of 4 results
Advanced filters: Author: Kyle D. Staller Clear advanced filters

  • Here, the authors identify distinct gut microbiome and metabolome signatures in microscopic colitis, a condition causing chronic diarrhea, highlighting pro-inflammatory species and metabolites as potential non-invasive biomarkers and therapeutic targets.

    • Albert Sheng-Yin Chen
    • Hanseul Kim
    • Hamed Khalili
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Microscopic colitis is a chronic inflammatory disease of the large intestine. Here the authors use single-cell RNA transcriptomic profiling and tissue localization studies to characterise the colon immune cell populations in MC, showing expansion of CD8 T cells with diverse TCR clonotypes and expression of CD4 T reg cell signatures.

    • Stefan Halvorsen
    • Molly Thomas
    • Hamed Khalili
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus with unclear immune cell involvement. Here the authors generate a single cell transcriptomic dataset with 400k cells from the esophageal mucosa of active EoE patients, remission EoE patients, and healthy individuals to characterise esophageal cellular composition, phenotype and interaction in this disease.

    • Jiarui Ding
    • John J. Garber
    • Ramnik J. Xavier
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18