The transcription factor ThPOK is critical for homeostasis and differentiation of mature helper T cells. Here, Kappes and colleagues describe a ThPOK-mediated positive autoregulatory loop that is crucial for tissue-specific Treg cell differentiation, maintenance of intestinal Treg cell integrity and conversion of these cells into CD4+ intraepithelial lymphocytes.
- Jayati Basu
- Bernardo S. Reis
- Dietmar J. Kappes
