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Showing 1–2 of 2 results
Advanced filters: Author: Kylynne Ferrara Clear advanced filters

  • A population of TRAIL-positive astrocytes in glioblastoma contributes to an immunosuppressive tumour microenvironment and this mechanism can be targeted with an engineered oncolytic virus to improve outcomes.

    • Camilo Faust Akl
    • Brian M. Andersen
    • Francisco J. Quintana
    Research
    Nature
    Volume: 643, P: 219-229

  • Lactate produced by dendritic cells (DCs) suppresses T-cell-mediated autoimmunity through a mechanism in which lactate activates HIF-1α–NDUFA4L2 signalling in DCs and thereby limits DC-mediated pro-inflammatory responses such as the development of encephalitogenic T cells.

    • Liliana M. Sanmarco
    • Joseph M. Rone
    • Francisco J. Quintana
    Research
    Nature
    Volume: 620, P: 881-889