In this Review, Karasik et al. summarize key advances from the past 5 years in understanding the genetics of bone traits and osteoporosis. Despite the wealth of new genetic and genomic information, its application to the clinical management of osteoporosis remains in its infancy. The notable advances made in gene discovery suggest that the next decade will witness cataloguing of hundreds of genes that influence bone mass, which, in turn, will provide a roadmap for the development of new bone-focused drug targets.
- David Karasik
- Fernando Rivadeneira
- Mark L. Johnson
