Nature Search

Unlocking Lewis acid catalysis in non-haem enzymes for an abiotic ene reaction

The scope of Lewis acid catalysis mediated by enzymes is low compared with the range of reactions it drives in organic synthesis. Now the substitution of the iron centre with copper, and the subsequent directed evolution, enabled a non-haem iron hydroxylase to efficiently catalyse asymmetric abiotic Conia-ene cyclizations.

Xinpeng Mu
Xinyuan Ji
Xiongyi Huang
Research04 Jul 2025
Nature Catalysis

Volume: 8, P: 635-644
Structural basis for Lewis antigen synthesis by the α1,3-fucosyltransferase FUT9

The structure, molecular and mechanistic details of the human α1,3-fucosyltransferase FUT9 provide insight into the synthesis of diverse and modified glycan-capping Lewis antigen structures by a conserved family of mammalian fucosyltransferases.

Renuka Kadirvelraj
Bhargavi M. Boruah
Kelley W. Moremen
Research18 May 2023
Nature Chemical Biology

Volume: 19, P: 1022-1030
Lewis and Bronsted Acid Sites on Silica-Alumina

N. W. CANT
L. H. LITTLE
Research02 Jul 1966
Nature

Volume: 211, P: 69-70
A general Lewis acidic etching route for preparing MXenes with enhanced electrochemical performance in non-aqueous electrolyte

Two-dimensional transition metal carbides and nitrides, known as MXenes, are currently considered as energy storage materials. A generic Lewis acidic etching route for preparing high-rate negative-electrode MXenes with enhanced electrochemical performance in non-aqueous electrolyte is now proposed.

Youbing Li
Hui Shao
Qing Huang
Research13 Apr 2020
Nature Materials

Volume: 19, P: 894-899
Nature of the Product condensed at Low Temperatures from Dissociated Peroxide Vapour

R. L. ALLEN
F. S. STONE
Research12 Oct 1957
Nature

Volume: 180, P: 752-753
Prof. W. J. Lewis, F.R.S

L. J. S.
Comments & Opinion01 May 1926
Nature

Volume: 117, P: 628-629
Natural Ionising Radiation and Rate of Mutation

E. B. BABCOCK
J. L. COLLINS
Research10 Aug 1929
Nature

Volume: 124, P: 227-228
Synthesis and screening of a library of Lewis^x deoxyfluoro-analogues reveals differential recognition by glycan-binding partners

Distinguishing between different proteins that each bind to the same type of glycan is challenging. Here, the authors demonstrate that an enzymatically synthesised library of Lewis^x ‘glycofluoroforms’ that feature site-specific fluorination can discriminate closely related proteins.

Kristian Hollingsworth
Antonio Di Maio
Bruno Linclau
ResearchOpen Access13 Sept 2024
Nature Communications

Volume: 15, P: 1-14
Tumor site-directed A1R expression enhances CAR T cell function and improves efficacy against solid tumors

The efficacy of CAR-T cells against solid tumors is still limited by immunosuppressive factors. Here, the authors show that engineering of CAR T cells with A1R enhances their efficacy against solid tumors in vitro and in vivo.

Kevin Sek
Amanda X. Y. Chen
Paul A. Beavis
ResearchOpen Access03 Jul 2025
Nature Communications

Volume: 16, P: 1-17
Supramolecular chirality largely modulates chemical doping of conjugated polymers

Chemical doping allows for boosting the conductivity in conjugated polymers but the relationship between doping and the polymers’ complex, multiscale morphology remains elusive. Here the authors report that supramolecular chirality, which up to now had not been considered a parameter relevant to doping, significantly boosts the underpinning redox reaction in conjugated polymer thin films.

Zhuang Xu
Shamil Saiev
Ying Diao
ResearchOpen Access25 Sept 2025
Nature Communications

Volume: 16, P: 1-16
Prof. F. J. Lewis

W. LAWRENCE BALLS
L. J. F. BRIMBLE
Comments & Opinion06 Aug 1955
Nature

Volume: 176, P: 237-238
Increasing tree size across Amazonia

A global research network monitoring the Amazon for 30 years reports in this study that tree size increased by 3% each decade.

Adriane Esquivel-Muelbert
Rebecca Banbury Morgan
Oliver L. Phillips
ResearchOpen Access25 Sept 2025
Nature Plants

P: 1-10
Sensitization to Skin Allografts after Kidney Perfusion in Rats

DONALD L. BALLANTYNE JUN.
PAUL NATHAN
SANFORD BLANK
Research01 Dec 1966
Nature

Volume: 212, P: 1553-1555
Distinction between “Self” and “Not-Self” in Lower Invertebrates

JACQUES L. THEODOR
Research15 Aug 1970
Nature

Volume: 227, P: 690-692
Native diversity buffers against severity of non-native tree invasions

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Camille S. Delavaux
Thomas W. Crowther
Daniel S. Maynard
ResearchOpen Access23 Aug 2023
Nature

Volume: 621, P: 773-781
Effect of Ultrasound on Fibrinogen in Human Plasma

RONALD L. SEARCY
LOIS M. BERGQUIST
JAMES A. FOREMAN
Research22 May 1965
Nature

Volume: 206, P: 795-796
Influence of Temperature on Lizard Testes

PAUL LICHT
SANKAR L. BASU
Research18 Feb 1967
Nature

Volume: 213, P: 672-674
Polygenic and developmental profiles of autism differ by age at diagnosis

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

Xinhe Zhang
Jakob Grove
Varun Warrier
ResearchOpen Access01 Oct 2025
Nature

P: 1-12
Metal organic framework derived In₂O₃/ZrO₂ heterojunctions with interfacial oxygen vacancies for highly selective CO₂-to-methanol hydrogenation

Achieving high selectivity in CO₂-to-methanol conversion remains challenging. This study uses defect-engineered In₂O₃/ZrO₂ catalysts featuring abundant oxygen vacancies, significantly boosting methanol productivity and selectivity.

Paramita Koley
Subhash Chandra Shit
Suresh K. Bhargava
ResearchOpen Access07 Oct 2025
Nature Communications

Volume: 16, P: 1-14
Redox-driven mineral and organic associations in Jezero Crater, Mars

A geological, petrographic and geochemical survey of distinctive mudstone and conglomerate outcrops of the Bright Angel formation on Mars reveals textures, chemical and mineral characteristics, and organic signatures that warrant consideration as potential biosignatures.

Joel A. Hurowitz
M. M. Tice
Z. U. Wolf
ResearchOpen Access10 Sept 2025
Nature

Volume: 645, P: 332-340
A continuously oxygenated macroencapsulation system enables high-density packing and delivery of insulin-secreting cells

Insufficient oxygen limits the efficacy of cell encapsulation therapies for type 1 diabetes. Here, the authors develop an implantable system that continuously generates oxygen to support high-density islet cell survival and function, enabling diabetes reversal in rats without immunosuppression.

Tung T. Pham
Phuong L. Tran
Minglin Ma
ResearchOpen Access11 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Improved allele frequencies in gnomAD through local ancestry inference

This study incorporates local ancestry into the Genome Aggregation Database (gnomAD) to improve allele frequency estimates for admixed populations, enhancing variant interpretation and enabling more accurate and equitable genomic research and clinical care.

Pragati Kore
Michael W. Wilson
Elizabeth G. Atkinson
ResearchOpen Access06 Oct 2025
Nature Communications

Volume: 16, P: 1-10
Multiple independent acquisitions of a metallophore-synthesis gene by plants through horizontal microbial gene transfer

Bacteria and fungi provide plants with enhanced access to mineral nutrients and water, but have also served as a source of genes to succeed on land. This study shows multiple independent transfers of a key gene for metal ion transport (NAS) to various plant lineages, highlighting a complex and dynamic history of gene exchange.

L. Dirick
Y. Liu
B. Goffinet
ResearchOpen Access22 Sept 2025
Nature Communications

Volume: 16, P: 1-8
Surgeon-Major T. R. Lewis

E. R. L.
Editorial27 May 1886
Nature

Volume: 34, P: 76-77
Estimating disorder probability based on polygenic prediction using the BPC approach

Here the authors present a method to transform polygenic scores into disorder probabilities using only GWAS summary statistics, genotype data and a prior - no tuning sample is needed. The method enables individualized, well-calibrated predictions.

Emil Uffelmann
Cathryn M. Lewis
Wouter J. Peyrot
ResearchOpen Access26 Sept 2025
Nature Communications

Volume: 16, P: 1-13
A single mutation in dairy cow-associated H5N1 viruses increases receptor binding breadth

Highly pathogenic avian influenza clade 2.3.4.4b H5N1 viruses are causing a multistate outbreak in dairy cows. In this study, the authors report that recent H5N1 viruses have acquired a single mutation that increases their receptor binding range, which may result in increased host range of H5N1.

Marina R. Good
Monica L. Fernández-Quintero
Jenna J. Guthmiller
ResearchOpen Access30 Dec 2024
Nature Communications

Volume: 15, P: 1-11
Development of the Thymus in the Human Fœtus and its Relation to Immunological Potential

H. E. M. KAY
J. H. L. PLAYFAIR
P. K. HOPPER
Research20 Oct 1962
Nature

Volume: 196, P: 238-240
Resistance of microorganisms to disinfection in dental and medical devices

David L. Lewis
Max Arens
Research01 Sept 1995
Nature Medicine

Volume: 1, P: 956-958
Magnetic and Spectral Evidence for Trinuclear Clusters in Molybdenum Chlorides

R. COLTON
R. L. MARTIN
Research10 Jul 1965
Nature

Volume: 207, P: 141-142
A methylome-wide association study of major depression with out-of-sample case–control classification and trans-ancestry comparison

The authors report a meta-analysis of methylome-wide association studies, identifying 15 significant CpG sites linked to major depression, revealing associations with inflammatory markers and suggesting potential causal relationships through Mendelian randomization analysis.

Xueyi Shen
Miruna Barbu
Andrew M. McIntosh
ResearchOpen Access16 Sept 2025
Nature Mental Health

Volume: 3, P: 1152-1167
Cationic silicon Lewis acids in catalysis

Silylium ions are highly reactive, strongly Lewis acidic and have historically been tricky to isolate. This Perspective highlights the range of methods available for their preparation and the latest examples of their use as catalysts or reagents in organic synthesis.

Johannes C. L. Walker
Hendrik F. T. Klare
Martin Oestreich
Reviews15 Nov 2019
Nature Reviews Chemistry

Volume: 4, P: 54-62
Perinatal expression of the Lewis and secretor blood group systems

Minerva B Arcilla
Phillip Sturgeon
Research01 Aug 1971
Pediatric Research

Volume: 5, P: 422-423
The three-dimensional structure of trp repressor

Richard W. Schevitz
Zdzislaw Otwinowski
Paul B. Sigler
Research01 Oct 1985
Nature

Volume: 317, P: 782-786
Measuring the semantic priming effect across many languages

In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

Erin M. Buchanan
Kelly Cuccolo
Savannah C. Lewis
Research24 Sept 2025
Nature Human Behaviour

P: 1-20
Molecular fusion of surfactant and Lewis-acid properties for attacking dirt by catalytic bond cleavage

Marvin L. Frisch
Sebastian Polarz
ResearchOpen Access04 Mar 2021
Scientific Reports

Volume: 11, P: 1-11
The ‘Gbr Experiment’ : A Trans-Atlantic Frequency Comparison Between Cæsium-Controlled Oscillators

J. A. PIERCE
G. M. R. WINKLER
R. L. CORKE
Research10 Sept 1960
Nature

Volume: 187, P: 914-916
Dose-Effect Measurements of Radiation Following Administration of Tritiated Thymidine

W. E. KISIELESKI
L. D. SAMUELS
P. C. HILEY
Research02 May 1964
Nature

Volume: 202, P: 458-459
Colour Anomaly, the Rayleigh Equation and Selective Adaptation

R. L. GREGORY
Research23 Jul 1955
Nature

Volume: 176, P: 172-173
Late Miocene Hominid from Fort Ternan, Kenya

E. L. SIMONS
Research01 Feb 1969
Nature

Volume: 221, P: 448-451
Structure of Condensed Tannins

L. L. CREASY
T. SWAIN
Research09 Oct 1965
Nature

Volume: 208, P: 151-153
FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression

Puan and San Luis et al. find that FUT6, encoding a fucosyltransferase, is required for the “rolling” behavior of certain white blood cells that enables them to move from blood vessels to tissues. They show that FUT6 deficiency leads to a loss of the tetrasaccharide sLex on the surface of basophils, resulting in cells that are less sticky and therefore less able to form the necessary adhesions for exiting the blood vessel to drive the allergic reaction.

Kia Joo Puan
Boris San Luis
Olaf Rötzschke
ResearchOpen Access02 Jul 2021
Communications Biology

Volume: 4, P: 1-13
Metabolism of Labelled Carcinogenic Hydrocarbons in Rats

P. M. DANIEL
O. E. PRATT
MARJORIE M. L. PRICHARD
Research09 Sept 1967
Nature

Volume: 215, P: 1142-1146
A STUB1–CHIC2 complex inhibits CD8⁺ T cells to restrain tumor immunity

LaFleur, Milling et al. perform an in vivo CRISPR screen of CD8⁺ T cells responding to tumors. They identify the E3 ubiquitin ligase STUB1 as a potent negative regulator of CD8⁺ T cell responses in tumors.

Martin W. LaFleur
Lauren E. Milling
Arlene H. Sharpe
Research12 Aug 2025
Nature Immunology

Volume: 26, P: 1476-1487
Effect of Concanavalin A on Lymphocyte-mediated Cytotoxicity

L. STAVY
A. J. TREVES
M. FELDMAN
Research02 Jul 1971
Nature

Volume: 232, P: 56-58
Brønsted acid-enhanced direct hydrogen atom transfer photocatalysis for selective functionalization of unactivated C(sp³)–H bonds

Functionalization of C–H bonds through direct hydrogen atom transfer (HAT) photocatalysis is an attractive synthetic reaction; however, many methods suffer from low catalytic efficiency. Now, the efficiency of direct HAT photocatalysis using photocatalyst eosin Y combined with Brønsted acids is reported, enabling the functionalization of unactivated C(sp³)–H bonds.

Hui Cao
Degong Kong
Jie Wu
Research04 Aug 2022
Nature Synthesis

Volume: 1, P: 794-803
Hydrogen evolution and dynamics in hydrogel electrochemical cells for ischemia–reperfusion therapy

A wearable hydrogel-based electrochemical platform is presented for on-demand hydrogen gas therapy, enabling localized gas generation, storage and sustained delivery. This device offers a therapeutic modality for treating ischemia–reperfusion heart disease and skin bedsores, expanding bioelectronics applications in gas-phase chemical delivery.

Wen Li
Jing Zhang
Bozhi Tian
Research15 Aug 2025
Nature Chemical Engineering

Volume: 2, P: 484-497
Visualization of silicone gel in human breast tissue using new infrared imaging spectroscopy

Linda H. Kidder
Victor F. Kalasinsky
E. Neil Lewis
Research01 Feb 1997
Nature Medicine

Volume: 3, P: 235-237
Author Correction: A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas

April A. Apfelbaum
Eric Morin
Pratiti Bandopadhayay
Amendments and CorrectionsOpen Access09 Oct 2025
Nature Communications

Volume: 16, P: 1
Eight Co-Ordination in the Early Transition Series

R. J. H. CLARK
D. L. KEPERT
J. LEWIS
Research10 Aug 1963
Nature

Volume: 199, P: 559-562
Positional signalling and specification of digits in chick limb morphogenesis

C. Tickle
D. Summerbell
L. Wolpert
Research20 Mar 1975
Nature

Volume: 254, P: 199-202

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