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High charge mobility while retaining signatures of quantum-confined states is obtained in films of surface-passivated HgTe quantum dots.

Magnetic fluctuations and random telegraph noise in vertical tunnelling heterostructure devices composed of vanadium-doped tungsten diselenide sandwiched between graphene layers can be tuned using an electric bias.

Polyadenylation stabilizes edited mitochondrial mRNAs in Trypanosoma brucei, but the involved poly(A) binding protein is unknown. Here, Mesitov et al. show that a pentatricopeptide repeat factor KPAF4 binds to A-tail and prevents exonucleolytic degradation as well as translation of incompletely edited mRNAs.

Combination therapy with the anti-HIV-1 monoclonal antibodies 3BNC117 and 10-1074 maintains long-term suppression in the absence of antiretroviral therapy in individuals with antibody-sensitive viral reservoirs.

Unlike Amazonian forests, African forests have maintained their carbon sink until recently but by 2030 the African carbon sink will have shrunk by 14 per cent and the Amazonian sink will reach almost zero.

Li et al. show that the epithelial–mesenchymal-transition transcription factor Snail induces claudin-11 expression and suppresses RhoA activity, thereby promoting collective migration and tumour progression in head and neck cancer.

Excessive inflammasome activation leads to inflammatory diseases, but how inflammasomes are regulated by PYD-only adaptors is unclear. Here the authors show that the PYD-only protein POP2 inhibits both inflammasome priming and assembly by interfering, respectively, with IκBα activation and NLRP3-ASC interaction.

RNA processing by alternative polyadenylation (APA) can result in 3′UTR diversity and regulation of target RNA function. Here the authors survey APA in viral infection of macrophages.

Transcription-coupled homologous recombination (TC-HR) is activated by reactive oxygen species-induced DNA damage to maintain transcribed genome stability. The authors demonstrate that R loops are induced by ROS at the transcribed genome, triggering a CSB-RAD52- dependent but BRCA1/2-independent RAD51 loading for repair.

The enzyme that directly activates the kinase PKC-θ during T cell antigen receptor signaling is still unknown. Tan and colleagues show that the serine-threonine kinase GLK is a direct activator of PKC-θ.

Teleconnections between tipping elements in the Earth system are unclear. Here the authors use a climate network approach to link the Amazon Rainforest Area and the Tibetan Plateau, and show that current snow cover loss on the Tibetan Plateau is an early warning signal for an approaching tipping point.

Spin waves are promising candidates as carriers for energy-efficient information processing, but they have not yet been fully explored application wise. Here the authors theoretically demonstrate that antiferromagnetic domain walls are naturally spin wave polarizers and retarders, two key components of magnonic devices.

JNK pathway-associated phosphatase (JKAP) is a dual-specificity phosphatase known to regulate substrates in several signalling cascades. Here, Li et al. demonstrate that JKAP has a key role in negative regulation of proximal T-cell receptor signalling and suppression of T-cell-mediated autoimmunity.

The bacterial symporter MelB transports galactosides with Na⁺, Li⁺ or H⁺ ions. Ethayathulla et al. present crystal structures of MelB in two distinct conformations, providing the first structural insights into the transport mechanism of a sodium-coupled permease of the major facilitator superfamily.

The spatial organisation of diffuse midline glioma-H3K27M mutant (DMG) and glioblastoma (GBM) remains to be investigated. Here, the authors integrate short-read and long-read spatial profiling of DMG and GBM to identify regulatory programs and cellular ecosystems in distinct glioma niches.

Laboratory experiments demonstrate that electrons are accelerated to high energies by the reconnection electric field in magnetically driven reconnection. This mechanism is expected to be relevant for many astrophysical environments.

Efficient photoprotection is vital for the maintenance of photosynthetic efficiency during photodamage. Here, the authors reveal that m⁶A writer VIRILIZER acts as a molecular switch of photoprotection by post-transcriptional regulation in plants.

A genome-wide association study of cerebral ventricle phenotypes finds 62 unique loci and reveals a genetic overlap between ventricular and neuropsychiatric traits.

A G1 cell cycle regulatory kinase Cip1 has been identified in budding yeast but how this is regulated is unclear. Here the authors identify cell cycle (Mcm1) and stress-mediated (Msn 2/4) transcription factors as regulating Cip1, causing stress induced CDK inhibition and delay in cell cycle progression.

Polariton condensation of topological propagating edge states is demonstrated with halide perovskite microcavities.

BHC80 is a component of the LSD1 co-repressor complex that demethylates histone H3 at lysine 4. The PHD domain of BHC80 interacts with the histone H3 tail only when lysine 4 is unmethylated, and BHC80 function is coupled to that of LSD1 in gene repression.

The Newtonian gravitational constant is measured with two independent methods, yielding results with relative standard uncertainties of 11.6 parts per million—the lowest uncertainty reported until now.

HIC2 regulates the fetal-to-adult hemoglobin switch. It inactivates an enhancer of the BCL11A gene, a fetal globin repressor, by reducing chromatin accessibility and displacing the transcription factor GATA1.

Two industrial chemicals are sustainably produced at large scale by microbial gas fermentation.

The BMP inhibitor GREM1 is a key regulator of cellular heterogeneity in pancreatic cancer in human and mouse.

ILC3s expressing MHC class II control the fate of inflammatory versus tolerogenic T cells that respond to the microbiota by selecting for antigen-specific RORγt⁺ T_reg cells and against T_H17 cells, establishing intestinal homoeostasis.

Han et al. report that the Hippo pathway kinases LATS1 and LATS2 phosphorylate the heavy metal response transcription factor MTF1, leading to attenuation of heavy metal response gene transcription and cellular detoxification.

Mitochondrial quality control prevents accumulation of intramitochondrial reactive oxygen species (mtROS), thus protecting cells against DNA damage. Here, Gao et al. show that an atypical heat shock factor responds to intramitochondrial stresses and regulates mtROS homeostasis in the pathogenic fungus Cryptococcus neoformans.

The antifungal drug naftifine blocks carotenoid pigment biosynthesis in Staphylococcus aureus through inhibition of a biosynthetic enzyme of staphyloxanthin, disabling an important virulence mechanism and thus making the pathogen susceptible to host oxidant killing.

The vascular, cellular and molecular changes underlying sex differences in mood disorders are unclear. Here, the authors show that blood-brain barrier dysfunction modulates anxiety- and depressive-like behaviors in female mice and endothelium-specific changes associated with maladaptive responses compared to resilience to stress.

PD-L1 is highly expressed in triple-negative breast cancers (TNBC). Here, the authors show that nucleophosmin 1 (NPM1) transcriptionally activates PD-L1 expression and inhibits T cell activity in TNBC.

Base editors can efficiently produce single nucleotide alterations without requiring a double-strand break. Here the authors show base editing at multiple sites simultaneously in pigs.

Single-cell transcriptional profiling of primary human synovial sarcoma tumors suggests that combinatorial treatment with HDAC and CDK4/CDK6 inhibitors could enhance tumor immunogenicity.

The development of split-engineered base editors (seBEs) enables small-molecule control over DNA deaminase activity, decreasing off-target effects and offering a generalizable solution for temporal control over precise genome editing.

A distinct class of broadly neutralizing antibodies to the influenza virus target a membrane-proximal anchor epitope of the haemagglutinin stalk domain.

The authors link neuronal expression of telomerase reverse transcriptase to amyloid pathology and cognitive dysfunction in preclinical models of Alzheimer’s disease.

Hydroxide exchange membrane fuel cells operating in alkaline electrolyte are more cost-effective than their proton exchange membrane counterparts, but their performance is still considerably lower. Now, a Ni–Mo–Nb metallic glass is put forward as a hydrogen oxidation reaction catalyst with high activity and stability in alkaline electrolyte.

The deubiquitinase CYLD regulates a TAK1–JNK pathway and can be targeted to ameliorate nonalcoholic steatohepatitis.

Pushes to globalize science must not threaten local innovations in developing countries, argues Lan Xue.

Lan et al. make single and triple phosphomimetic mutations in a long flexible loop domain of BCL-2 and show that these mutations reduce structural flexibility and promote ligand access to the groove. Their study indicates that changes in structural flexibility on an unstructured loop can activate an allosteric, otherwise inactive protein.

DEL-1 protein interferes with leukocyte adhesion to prevent inflammation. Chavakis and colleagues now show that DEL-1 contributes to tissue resolution after inflammation by promoting macrophage-mediated efferocytosis and M2-like pro-resolving activities.

Zhang et al. show that ALK phosphorylates SMAD4 at Tyr 95 to block its binding to DNA, representing a mutation-independent mechanism for blocking the tumour suppressor function of TGF-β in ALK-positive cancers.

High-nuclearity silver clusters are appealing synthetic targets for their remarkable structures, but most are isolated serendipitously. Here, the authors describe the rational use of solvents to form cluster-in-cluster silver nanowheels, which comprise an octahedral Ag₆⁴⁺ core surrounded by a Ag₅₆ cage of unusual seven-fold symmetry.

A study of over 250,000 pregnant women in Beijing, China, finds that missed abortion is associated with the concentration of four major air pollutants. The association is not linear but becomes stronger with higher concentrations.

Monitoring catalyst structural changes under working conditions is crucial for understanding how catalysts operate. Here, authors examine single-atom Ru electrocatalyst by operando synchrotron spectroscopies to identify the catalytic mechanism during the acidic oxygen evolution reaction.