Nature Search

Causes of more frequent deletions than insertions in mutations and protein evolution

Wilfried W. de Jong
Lars Rydén
Research12 Mar 1981
Nature

Volume: 290, P: 157-159
Substituted benzimidazoles inhibit gastric acid secretion by blocking (H⁺ + K⁺) ATPase

Erik Fellenius
Thomas Berglindh
Björn Wallmark
Research12 Mar 1981
Nature

Volume: 290, P: 159-161
Human class II major histocompatibility antigen β-chains are derived from at least three loci

Jan Böhme
David Owerbach
Lars Rask
Research06 Jan 1983
Nature

Volume: 301, P: 82-84
Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Gut microbial metabolism of nutrients contributes to metabolic diseases, and the histidine metabolite imidazole propionate (ImP) is produced by type 2 diabetes (T2D) associated microbiome. Here the authors report that circulating ImP levels are increased in subjects with prediabetes or T2D in three European populations, and this increase associates with altered gut microbiota rather than dietary histidine.

Antonio Molinaro
Pierre Bel Lassen
Fredrik Bäckhed
ResearchOpen Access18 Nov 2020
Nature Communications

Volume: 11, P: 1-10
Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide

TMAO is known to be atherothrombotic. Here the authors show that i) kidney function is the main determinant of serum TMAO, ii) TMAO increases kidney scarring with TGF-β1 signalling and iii) anti-diabetic drugs with reno-protective properties such as GLP1R agonists reduce plasma TMAO.

Petros Andrikopoulos
Judith Aron-Wisnewsky
Marc-Emmanuel Dumas
ResearchOpen Access20 Sept 2023
Nature Communications

Volume: 14, P: 1-18
Bird pollination of Canary Island endemic plants

Jeff Ollerton
Louise Cranmer
Lars Chittka
ResearchOpen Access16 Jun 2008
Nature Precedings

P: 1
Cortical depth profiles in primary visual cortex for illusory and imaginary experiences

Whether visual illusions and mental imagery are similarly represented in visual cortex is not well understood. Here, the authors show that imagery content is mainly detectable in deep layers of V1, whereas illusory content is decodable mainly from superficial layers.

Johanna Bergmann
Lucy S. Petro
Lars Muckli
ResearchOpen Access02 Feb 2024
Nature Communications

Volume: 15, P: 1-13
Reply to “Clinical trials: Testing the hypothesis”

Michael Baum
Lars Holmberg
Correspondence01 Oct 1995
Nature Medicine

Volume: 1, P: 976-977
Statin therapy is associated with lower prevalence of gut microbiota dysbiosis

A cross-sectional analysis of participants in the MetaCardis Body Mass Index Spectrum cohort finds that the higher prevalence of gut microbiota dysbiosis in individuals with obesity is not observed in those who take statin drugs.

Sara Vieira-Silva
Gwen Falony
Jeroen Raes
Research06 May 2020
Nature

Volume: 581, P: 310-315
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Microbiome and metabolome features of the cardiometabolic disease spectrum

By studying individuals along a spectrum of cardiometabolic disease and adjusting for effects of lifestyle and medication, this investigation identifies alterations of the metabolome and microbiome from dysmetabolic conditions, such as obesity and type 2 diabetes, to ischemic heart disease.

Sebastien Fromentin
Sofia K. Forslund
Oluf Pedersen
ResearchOpen Access17 Feb 2022
Nature Medicine

Volume: 28, P: 303-314
The genetic architecture of type 2 diabetes

Sequencing data from two large-scale studies show that most of the genetic variation influencing the risk of type 2 diabetes involves common alleles and is found in regions previously identified by genome-wide association studies, clarifying the genetic architecture of this disease.

Christian Fuchsberger
Jason Flannick
Mark I. McCarthy
Research11 Jul 2016
Nature

Volume: 536, P: 41-47
Combinatorial, additive and dose-dependent drug–microbiome associations

An analysis of 2,173 individuals from the MetaCardis cohort quantifies the individual and combinatorial effects of a range of drugs on host health, metabolome and gut microbiome in cardiometabolic disease.

Sofia K. Forslund
Rima Chakaroun
Peer Bork
Research08 Dec 2021
Nature

Volume: 600, P: 500-505
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

Barbara Franke
Jason L Stein
Patrick F Sullivan
Research01 Feb 2016
Nature Neuroscience

Volume: 19, P: 420-431
Clinical recommendations for dry powder inhaler use in the management of COPD in primary care

Marika T. Leving
Sinthia Bosnic-Anticevich
Janwillem W. H. Kocks
ResearchOpen Access27 Dec 2022
npj Primary Care Respiratory Medicine

Volume: 32, P: 1-8
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mammalian genomes are scattered with repetitive sequences, but their biology remains largely elusive. Here, the authors show that transcription can initiate from short tandem repetitive sequences, and that genetic variants linked to human diseases are preferentially found at repeats with high transcription initiation level.

Mathys Grapotte
Manu Saraswat
Charles-Henri Lecellier
ResearchOpen Access02 Jun 2021
Nature Communications

Volume: 12, P: 1-18
Author Correction: Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Antonio Molinaro
Pierre Bel Lassen
Fredrik Bäckhed
Amendments and CorrectionsOpen Access21 Dec 2020
Nature Communications

Volume: 11, P: 1
Bottom-up effects of plant diversity on multitrophic interactions in a biodiversity experiment

The effects of biodiversity on ecosystem function are usually studied within trophic levels. These authors conduct a large experiment across trophic levels to show how manipulations of plant diversity affect function in different groups. The effects are consistent across groups, but are stronger at adjacent trophic levels and in above-ground rather than below-ground groups.

Christoph Scherber
Nico Eisenhauer
Teja Tscharntke
Research27 Oct 2010
Nature

Volume: 468, P: 553-556
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

Kyle Gaulton, Mark McCarthy, Andrew Morris and colleagues report fine mapping and genomic annotation of 39 established type 2 diabetes susceptibility loci. They find that the set of potential causal variants is enriched for overlap with FOXA2 binding sites in human islet and liver cells, and they show that a likely causal variant near MTNR1B increases FOXA2-bound enhancer activity, providing a molecular mechanism to explain the effect of this locus on disease risk.

Kyle J Gaulton
Teresa Ferreira
Andrew P Morris
Research09 Nov 2015
Nature Genetics

Volume: 47, P: 1415-1425
Wafer-scale design of lightweight and transparent electronics that wraps around hairs

Realising flexible, lightweight and transparent electronics is a continuous challenge. Here, the authors report a process to create such transistor devices, which can be transferred onto various flexible substrates, and continue to function when wrapped around human hairs.

Giovanni A. Salvatore
Niko Münzenrieder
Gerhard Tröster
Research07 Jan 2014
Nature Communications

Volume: 5, P: 1-8
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

Cristian Pattaro
Alexander Teumer
Caroline S. Fox
ResearchOpen Access21 Jan 2016
Nature Communications

Volume: 7, P: 1-19
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group

Sarah M. C. Colbert
Eric T. Monson
Lea Zillich
ReviewsOpen Access25 Sept 2025
Molecular Psychiatry

P: 1-11
KIR expression on self-reactive CD8⁺ T cells is controlled by T-cell receptor engagement

Bertrand Huard
Lars Karlsson
Research20 Jan 2000
Nature

Volume: 403, P: 325-328
Factors associated with health status and exacerbations in COPD maintenance therapy with dry powder inhalers

Janwillem W. H. Kocks
Hans Wouters
Marika T. Leving
ResearchOpen Access26 May 2022
npj Primary Care Respiratory Medicine

Volume: 32, P: 1-10
A giant planet undergoing extreme-ultraviolet irradiation by its hot massive-star host

The giant planet KELT-9b has a dayside temperature of about 4,600 K, which is sufficiently high to dissociate molecules and to evaporate its atmosphere, owing to its hot stellar host.

B. Scott Gaudi
Keivan G. Stassun
Patricia Trueblood
Research05 Jun 2017
Nature

Volume: 546, P: 514-518
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Neuroinflammation in frontotemporal dementia

An altered microglial landscape and ageing-related inflammatory changes contribute to the neurodegeneration associated with frontotemporal dementia (FTD). Here, Bright and colleagues discuss the evidence for a pathogenetic role of neuroinflammatory mechanisms in FTD, including links with autoimmunity and gene mutations associated with neuroinflammation.

Fiona Bright
Eryn L. Werry
Jillian J. Kril
Reviews19 Jul 2019
Nature Reviews Neurology

Volume: 15, P: 540-555
Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mathys Grapotte
Manu Saraswat
Charles-Henri Lecellier
Amendments and CorrectionsOpen Access01 Mar 2022
Nature Communications

Volume: 13, P: 1
International network of cancer genome projects

Thomas J. Hudson (Chairperson)
Warwick Anderson
Huanming Yang
Reviews15 Apr 2010
Nature

Volume: 464, P: 993-998
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

Malcolm G Dunlop
Sara E Dobbins
Richard S Houlston
Research27 May 2012
Nature Genetics

Volume: 44, P: 770-776
Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Jason Flannick
Christian Fuchsberger
Mark I. McCarthy
Amendments and CorrectionsOpen Access23 Jan 2018
Scientific Data

Volume: 5, P: 1-2
Altered serum protein levels in frontotemporal dementia and amyotrophic lateral sclerosis indicate calcium and immunity dysregulation

Jared S. Katzeff
Fiona Bright
Woojin Scott Kim
ResearchOpen Access13 Aug 2020
Scientific Reports

Volume: 10, P: 1-12
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Jason Flannick
Christian Fuchsberger
Mark I. McCarthy
ResearchOpen Access19 Dec 2017
Scientific Data

Volume: 4, P: 1-22
Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome

Victoria L. Cammann
Jan F. Scheitz
Thomas F. Lüscher
ResearchOpen Access07 Dec 2021
Scientific Reports

Volume: 11, P: 1-14
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22

Search

Causes of more frequent deletions than insertions in mutations and protein evolution

Substituted benzimidazoles inhibit gastric acid secretion by blocking (H⁺ + K⁺) ATPase

Human class II major histocompatibility antigen β-chains are derived from at least three loci

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide

Bird pollination of Canary Island endemic plants

Cortical depth profiles in primary visual cortex for illusory and imaginary experiences

Reply to “Clinical trials: Testing the hypothesis”

Statin therapy is associated with lower prevalence of gut microbiota dysbiosis

Mapping the human genetic architecture of COVID-19

Microbiome and metabolome features of the cardiometabolic disease spectrum

The genetic architecture of type 2 diabetes

Combinatorial, additive and dose-dependent drug–microbiome associations

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Clinical recommendations for dry powder inhaler use in the management of COPD in primary care

Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Author Correction: Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

Bottom-up effects of plant diversity on multitrophic interactions in a biodiversity experiment

A second update on mapping the human genetic architecture of COVID-19

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

Wafer-scale design of lightweight and transparent electronics that wraps around hairs

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group

KIR expression on self-reactive CD8⁺ T cells is controlled by T-cell receptor engagement

Factors associated with health status and exacerbations in COPD maintenance therapy with dry powder inhalers

A giant planet undergoing extreme-ultraviolet irradiation by its hot massive-star host

At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Neuroinflammation in frontotemporal dementia

Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

International network of cancer genome projects

Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Altered serum protein levels in frontotemporal dementia and amyotrophic lateral sclerosis indicate calcium and immunity dysregulation

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Clinical correlates and prognostic impact of neurologic disorders in Takotsubo syndrome

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

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