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Tumor-associated neutrophil precursors impair homologous DNA repair and promote sensitivity to PARP inhibition

Tumor-associated neutrophils exhibit heterogeneity in breast cancer. Here, the authors identify a distinct precursor population (PreNeu) in estrogen receptor-positive tumors. PreNeu suppress homologous recombination in cancer cells, promoting error-prone DNA repair and enhancing sensitivity to PARP inhibitors.

Siddhartha Mukherjee
Cindy Garda
Arianna Calcinotto
ResearchOpen Access30 Jul 2025
Nature Communications

Volume: 16, P: 1-20
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Increased ectodysplasin-A2-receptor EDA2R is a ubiquitous hallmark of aging and mediates parainflammatory responses

In a broad cross-tissue analysis, the authors show that a receptor called EDA2R steadily increases with age in both humans and animal models, and becomes even more active in conditions like obesity and diabetes, intensifying inflammation-like processes in muscle cells.

Maria Chiara Barbera
Luca Guarrera
Marco Bolis
ResearchOpen Access23 Feb 2025
Nature Communications

Volume: 16, P: 1-11
Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

Honor Bixby
James Bentham
Majid Ezzati
ResearchOpen Access08 May 2019
Nature

Volume: 569, P: 260-264
Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression

Transcriptional changes during prostate cancer progression are not yet fully understood. Here, the authors integrate a transcriptomics atlas of prostate cancer and validate it with preclinical models and single-cell RNA-seq, revealing the role of EZH2 and macrophage polarisation in tumour progression.

Marco Bolis
Daniela Bossi
Jean-Philippe P. Theurillat
ResearchOpen Access02 Dec 2021
Nature Communications

Volume: 12, P: 1-15

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Tumor-associated neutrophil precursors impair homologous DNA repair and promote sensitivity to PARP inhibition

Diminishing benefits of urban living for children and adolescents’ growth and development

Increased ectodysplasin-A2-receptor EDA2R is a ubiquitous hallmark of aging and mediates parainflammatory responses

Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression

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