Nature Search

The embryonic zebrafish brain is seeded by a lymphatic-dependent population of mrc1⁺ microglia precursors

Green and O’Dea et al. identify that the embryonic zebrafish brain is colonized by a population of early-colonizing microglia that are dependent on lymphatic vessels, placing lymphatic cells at the epicenter of microglia development.

Lauren A. Green
Michael R. O’Dea
Cody J. Smith
Research16 Jun 2022
Nature Neuroscience

Volume: 25, P: 849-864
Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity

Dalit, Tan and colleagues provide a multiomic profile of T follicular helper (T_FH) cells responses to diverse pathogens, revealing a blueprint for transcriptional flexibility and new tools to interrogate T_FH heterogeneity in mice and humans.

Lennard Dalit
Chin Wee Tan
Joanna R. Groom
ResearchOpen Access09 Sept 2025
Nature Immunology

Volume: 26, P: 1821-1835
Evaluation of the US COVID-19 Scenario Modeling Hub for informing pandemic response under uncertainty

The US COVID-19 Scenario Modeling Hub produced medium to long term projections based on different epidemic scenarios. In this study, the authors evaluate 14 rounds of projections by comparing them to the epidemic trajectories that occurred, and discuss lessons learned for future similar projects.

Emily Howerton
Lucie Contamin
Justin Lessler
ResearchOpen Access20 Nov 2023
Nature Communications

Volume: 14, P: 1-15
Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy

Synaptic vesicle dysfunction in Parkinson’s disease is unexplored. Here, using electron microscopy, lipidomic and proteomic analyses, Gao et al. provide insights into synaptic vesicle biology and disease mechanisms.

Virginia Gao
Julita Chlebowicz
Jacqueline Burré
ResearchOpen Access01 May 2025
Nature Communications

Volume: 16, P: 1-25
Mapping cellular interactions from spatially resolved transcriptomics data

Spacia is a multiple-instance learning model for cell–cell communication (CCC) interference in single-cell resolution spatially resolved transcriptomics data. Spacia can map complex CCCs by modeling cell proximity and CCC-driven gene perturbation.

James Zhu
Yunguan Wang
Tao Wang
Research03 Sept 2024
Nature Methods

Volume: 21, P: 1830-1842
Patterns and consequences of age-linked change in local relatedness in animal societies

A model of how local relatedness changes with age fits empirical patterns from seven group-living mammal species and reveals that patterns differ between the sexes and the potential behavioural consequences of these changes.

Samuel Ellis
Rufus A. Johnstone
Darren P. Croft
Research26 Sept 2022
Nature Ecology & Evolution

Volume: 6, P: 1766-1776
A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometry

MHC restriction depicts CD4⁺ T cell activation by MHC-II and CD8A⁺ by MHC-I, but rare T cells with mismatched MHC restriction have been reported. Here the authors use crystallography to describe features of such a mismatched TCR-MHC interaction and implicate an atypical TCR structure and TCR-MHC interface as contributing factors.

Nishant K. Singh
Jesus A. Alonso
Brian M. Baker
ResearchOpen Access23 Nov 2022
Nature Communications

Volume: 13, P: 1-14
Urinary tract colonization is enhanced by a plasmid that regulates uropathogenic Acinetobacter baumannii chromosomal genes

Acinetobacter baumannii is generally considered an opportunistic pathogen. Here, Di Venanzio et al. develop a mouse model of catheter-associated urinary tract infection and show that a plasmid confers niche specificity to an A. baumannii urinary isolate by regulating the expression of chromosomal genes.

Gisela Di Venanzio
Ana L. Flores-Mireles
Mario F. Feldman
ResearchOpen Access24 Jun 2019
Nature Communications

Volume: 10, P: 1-13
Multilevel animal societies can emerge from cultural transmission

Multilevel societies are comprised of hierarchically nested levels of social organization, but how they arise is not well understood. Here Cantor et al. find that the emergence of sperm whale clans is more likely to be driven by cultural transmission of acoustic repertoires than via stochastic processes.

Maurício Cantor
Lauren G. Shoemaker
Hal Whitehead
ResearchOpen Access08 Sept 2015
Nature Communications

Volume: 6, P: 1-10
Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA

A new high-throughput platform to find rare T cells that can recognize shared cancer neoantigens identifies T cell receptors specific for a conserved, immunogenic and therapeutically actionable epitope in mutant PI3Kα, one of the most common driver oncogenes

Smita S. Chandran
Jiaqi Ma
Christopher A. Klebanoff
ResearchOpen Access28 Apr 2022
Nature Medicine

Volume: 28, P: 946-957
A close-in giant planet escapes engulfment by its star

The giant planet 8 Ursae Minoris b seems to have avoided engulfment by its giant host star through a stellar merger that either affected the evolution of the host star or produced 8 Ursae Minoris b as a second-generation planet.

Marc Hon
Daniel Huber
Lauren M. Weiss
Research28 Jun 2023
Nature

Volume: 618, P: 917-920
Continental-scale decrease in net primary productivity in streams due to climate warming

An increase in stream temperature leads to a convergence of metabolic balance, overall decline in net ecosystem productivity, and higher CO₂ emissions from streams, according to analyses of temperature sensitivity of stream metabolism across six biomes.

Chao Song
Walter K. Dodds
Ford Ballantyne IV
Research21 May 2018
Nature Geoscience

Volume: 11, P: 415-420
Evidence for the volatile-rich composition of a 1.5-Earth-radius planet

A comprehensive study of the Kepler-138 system reveals the twin nature of Kepler-138 c and d and the presence of a fourth planet. Remarkably, the warm-temperate planet Kepler-138 d is probably composed of 50% volatiles by volume, indicative of a water world, rather than a rocky world, despite its small ~1.5 R_⊕ size.

Caroline Piaulet
Björn Benneke
Ian Wong
Research15 Dec 2022
Nature Astronomy

Volume: 7, P: 206-222
Earthworms facilitate carbon sequestration through unequal amplification of carbon stabilization compared with mineralization

The presence of earthworms in soil may significantly increase CO₂ emissions, but the impacts of earthworms on net carbon sequestration are poorly understood. Zhang et al. introduce a new concept by which the effects of earthworms on the balance of carbon mineralization and stabilization can be quantified.

Weixin Zhang
Paul F. Hendrix
Shenglei Fu
Research15 Oct 2013
Nature Communications

Volume: 4, P: 1-9
An assistive computer vision tool to automatically detect changes in fish behavior in response to ambient odor

Sreya Banerjee
Lauren Alvey
Walter J. Scheirer
ResearchOpen Access13 Jan 2021
Scientific Reports

Volume: 11, P: 1-12
The weights of refinement and flexibility

IACUCs need to ensure the application of the 3Rs, while allowing researchers to conduct their work with reasonable flexibility. We invited experts from the University of Notre Dame (Eric Felde) and Northwestern University (Stefanie Bittner), along with USDA and OLAW representatives (Louis DiVincenti and Axel Wolff) to respond to a challenging situation at Great Eastern University.

Lauren Danridge
Bill Greer
Axel Wolff
Comments & Opinion02 Feb 2024
Lab Animal

Volume: 53, P: 23-25
A genome-wide linkage and association scan reveals novel loci for autism

Autism is a highly heritable neurodevelopmental disorder, and yet few specific susceptibility genes have been identified to date. A linkage and association mapping study using half a million genome-wide single nucleotide polymorphisms is now described in a common set of 1,031 multiplex autism families. The linkage regions identified provide targets for rare variation screening whereas the discovery of a single novel association, SEMA5A, demonstrates the action of common variants.

Lauren A. Weiss
Dan E. Arking
Leena Peltonen
Research08 Oct 2009
Nature

Volume: 461, P: 802-808
Multicenter retrospective cohort study of the sequential use of the antibody-drug conjugates (ADCs) trastuzumab deruxtecan (T-DXd) and sacituzumab govitecan (SG) in patients with HER2-low metastatic breast cancer (MBC)

Laura A. Huppert
Reshma Mahtani
Hope S. Rugo
ResearchOpen Access15 Apr 2025
npj Breast Cancer

Volume: 11, P: 1-8
A communal catalogue reveals Earth’s multiscale microbial diversity

As phase 1 of the Earth Microbiome Project, analysis of 16S ribosomal RNA sequences from more than 27,000 environmental samples delivers a global picture of the basic structure and drivers of microbial distribution.

Luke R. Thompson
Jon G. Sanders
Hongxia Zhao
ResearchOpen Access01 Nov 2017
Nature

Volume: 551, P: 457-463
The United States COVID-19 Forecast Hub dataset

Estee Y. Cramer
Yuxin Huang
Nicholas G. Reich
ResearchOpen Access01 Aug 2022
Scientific Data

Volume: 9, P: 1-15
Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture

Human population genomic studies, including whole‐genome sequencing, were undertaken to identify determinants of bone mineral density (BMD), a major predictor of osteoporotic fractures. Non‐coding variants with large effects on BMD and fractures were identified near the EN1 locus and mouse studies confirmed this gene has an important role in skeletal biology.

Hou‐Feng Zheng
Vincenzo Forgetta
J. Brent Richards
Research14 Sept 2015
Nature

Volume: 526, P: 112-117
School-based screening and treatment may reduce P. falciparum transmission

Lauren M. Cohee
Clarissa Valim
Miriam K. Laufer
ResearchOpen Access25 Mar 2021
Scientific Reports

Volume: 11, P: 1-11
MIReAD, a minimum information standard for reporting arthropod abundance data

Samuel S. C. Rund
Kyle Braak
Samraat Pawar
ResearchOpen Access25 Apr 2019
Scientific Data

Volume: 6, P: 1-8
An integrative re-evaluation of Typhlatya shrimp within the karst aquifer of the Yucatán Peninsula, Mexico

Lauren Ballou
David Brankovits
Elizabeth Borda
ResearchOpen Access29 Mar 2022
Scientific Reports

Volume: 12, P: 1-17
The translational potential of research on the ethical, legal, and social implications of genomics

Wylie Burke
Paul Appelbaum
Eric Juengst
Reviews19 Jun 2014
Genetics in Medicine

Volume: 17, P: 12-20

Search

The embryonic zebrafish brain is seeded by a lymphatic-dependent population of mrc1⁺ microglia precursors

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity

Evaluation of the US COVID-19 Scenario Modeling Hub for informing pandemic response under uncertainty

Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy

Mapping cellular interactions from spatially resolved transcriptomics data

Patterns and consequences of age-linked change in local relatedness in animal societies

A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometry

Urinary tract colonization is enhanced by a plasmid that regulates uropathogenic Acinetobacter baumannii chromosomal genes

Multilevel animal societies can emerge from cultural transmission

Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA

A close-in giant planet escapes engulfment by its star

Continental-scale decrease in net primary productivity in streams due to climate warming

Evidence for the volatile-rich composition of a 1.5-Earth-radius planet

Earthworms facilitate carbon sequestration through unequal amplification of carbon stabilization compared with mineralization

An assistive computer vision tool to automatically detect changes in fish behavior in response to ambient odor

The weights of refinement and flexibility

A genome-wide linkage and association scan reveals novel loci for autism

Multicenter retrospective cohort study of the sequential use of the antibody-drug conjugates (ADCs) trastuzumab deruxtecan (T-DXd) and sacituzumab govitecan (SG) in patients with HER2-low metastatic breast cancer (MBC)

A communal catalogue reveals Earth’s multiscale microbial diversity

The United States COVID-19 Forecast Hub dataset

Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture

School-based screening and treatment may reduce P. falciparum transmission

MIReAD, a minimum information standard for reporting arthropod abundance data

An integrative re-evaluation of Typhlatya shrimp within the karst aquifer of the Yucatán Peninsula, Mexico

The translational potential of research on the ethical, legal, and social implications of genomics

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