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Showing 1–4 of 4 results
Advanced filters: Author: Lauren LeBon Clear advanced filters

  • ISR-specific contributions to stress-induced cellular outputs are not well understood. Here,

    authors use a minimal activation system and multi-omics to define an ISR-sufficient metabolic state that includes protective accumulation of lipid droplets.

    • Katherine Labbé
    • Lauren LeBon
    • Carmela Sidrauski
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • The activity of translation initiation factor eIF2B is known to be modulated through stress-responsive phosphorylation of its substrate eIF2. Here, the authors uncover the regulation of eIF2B by the binding of sugar phosphates, suggesting a link between nutrient status and the rate of protein synthesis.

    • Qi Hao
    • Jin-Mi Heo
    • Carmela Sidrauski
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Notch and Delta are transmembrane proteins that allow neighbouring cells to communicate during development. Here, quantitative time-lapse microscopy has been used to show that the response of Notch to Delta on a neighbouring cell is graded, whereas its response to Delta on the same cell is sharp and occurs at a fixed threshold. A mathematical model explores how this new design principle enhances the sharpness of developmental boundaries set by classical lateral inhibition.

    • David Sprinzak
    • Amit Lakhanpal
    • Michael B. Elowitz
    Research
    Nature
    Volume: 465, P: 86-90