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Showing 1–5 of 5 results
Advanced filters: Author: Leif Oxburgh Clear advanced filters

  • Human kidneys have many features in common with those of other species, but also unique properties. A detailed human–mouse comparison of the genetic programme governing early events in nephron formation has revealed interspecies differences that could explain how nephron number in adult kidneys is determined.

    • Leif Oxburgh
    News & Views
    Nature Reviews Urology
    Volume: 13, P: 304-305

  • Available evidence suggests that the kidney stroma mediates cell communication and supports a variety of processes during kidney development and in the adult kidney. This Review describes the developmental origins of the stroma and current understanding of its roles in the growth and patterning of renal epithelia and endothelia, and in the maintenance and repair of the adult organ.

    • Alexandria N. Fusco
    • Leif Oxburgh
    • Thomas J. Carroll
    Reviews
    Nature Reviews Nephrology
    Volume: 21, P: 756-777

  • The growth factors BMP and FGF both stimulate the self-renewal of nephron progenitor cells (NPCs), but how these signals overlap is unclear. Here in the mouse, Muthukrishnan et al. find BMP7 and FGF9 coordinately regulate AP-1 transcriptional activity, promoting G1-S cell cycle progression and NPC proliferation.

    • Sree Deepthi Muthukrishnan
    • Xuehui Yang
    • Leif Oxburgh
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13

  • Ashwani Gupta et al. report an improved protocol for kidney organoid differentiation from pluripotent stem cells. The authors simulate the condition of the fetal kidney by mixing cells differentiated at different times from the same organoid, thereby promoting nephrogenesis in vitro and vascularization after engraftment under the kidney capsule in mice.

    • Ashwani Kumar Gupta
    • Prasenjit Sarkar
    • Leif Oxburgh
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-11

  • Mesangial cells are stromal cells that are important for kidney glomerular homeostasis and the glomerular response to injury. This Perspective reviews advances in our understanding of mesenchymal stromal cell function and describes how these insights can inform our understanding of mesangial cells and their role in disease.

    • Shimrit Avraham
    • Ben Korin
    • Andrey S. Shaw
    Reviews
    Nature Reviews Nephrology
    Volume: 17, P: 855-864