Fibrosis is characterized by excessive accumulation of connective tissue components in organs or tissues and is a critical, and potentially lethal, component of systemic sclerosis (SSc). Here, the authors describe the pathological role of fibrosis in the development of SSc, outlining the crucial triggers of fibrosis (including endothelium, aberrant immune responses and endoplasmic reticulum stress, among others).
- Yuen Yee Ho
- David Lagares
- Mohit Kapoor
