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Zero-dimensional hybrid copper halides show symmetry-dependent luminescence, enabling selective chiral recognition by coupling structural transformations with distinct optical responses.

A dual interfacial hydrogen-bond passivation strategy and a hybrid copper–iodide are used to fabricate deep-blue light-emitting diodes with excellent external quantum efficiency and lifetime.

Inspired by class II aldolases found in nature, the authors report a biomimetic copper/squaramide cooperative catalysis strategy for asymmetric Mannich reactions between challenging acyclic ketimines and α-substituted β-keto esters.

Deep understanding of defect physics, excitonic properties and the ultrafast carrier dynamics in the high mobility p-type transparent CuI is vital for its optoelectronic applications. Here, Liu et al. employ a synergistic approach to unveil these fundamental properties.

Solution-processed copper–iodide clusters are employed as efficient emitters for warm white LEDs with external quantum efficiency of 19.1%.

C–C bond cleavage and recombination provide an efficient strategy for the modification and reconstruction of molecular structures. Herein, the authors report a method to achieve amidation of aryl C(sp2)–H bonds by cleavage and recombination of C–C triple bonds with the participation of nitrous acid esters.

A proteotoxic stress response specific to exhausted T cells, governed by AKT signaling and accompanied by increased protein translation, represents a mechanistic vulnerability and a new therapeutic target to improve cancer immunotherapies.

Enantioselective oxidative cross-coupling of unactivated C(sp³)−H bonds and terminal alkynes is challenging. Here, the authors developed a copper/cinchona alkaloid catalyst for the asymmetric Sonogashira-type alkynylation of C(sp³)-H bonds via radical intermediates.

Fungal diseases threaten crops worldwide. By resolving the cryo-EM structure of fungal succinate dehydrogenase, researchers designed an inhibitor with broad antifungal activity, strong field performance, and reduced environmental toxicity.

Catalytic multicomponent carbonylation reactions with high regio- and chemoselectivity represent one of the long-pursued goals in C1 chemistry. Here, the authors report a cobalt-catalyzed divergent radical alkene carbonylative functionalization under 1 atm of CO at 23 °C.

Li-metal batteries often utilize liquid electrolytes that yield a solid–electrolyte interphase on electrodes; however, the role of anions in interphase formation remains unclear. Now it has been shown that anion-decomposition products provide varying contributions to interphase formation and that high-performance electrolytes balance effective interfacial passivation with minimized degradation.

‘Ultrathin’ gold interlayers are shown to form nanoparticles that balance optical losses and electrical contact, enabling efficient perovskite–perovskite integration for scalable and durable triple-junction photovoltaics.

The performance of Li-ion batteries deteriorates at elevated temperatures due to increased activity of electrode materials and parasitic reactions. Here Yi Cui and colleagues report much-improved battery cyclability at 60 °C and use cryo-electron microscopy to shed light on the origin of the phenomenon.

Dihydrouridine (D) is an abundant RNA modification but its functions are currently unclear. Here, authors develop CRACI, a sensitive method for transcriptome-wide, single-base D mapping, identifying sites across mammalian and plant transcriptomes and identifying DUS2L as a mitochondrial D writer.

Efficient exchange of long-chain ligands has been challenging for high-performing perovskite quantum dot photovoltaics. Here, the authors construct alkaline environments for antisolvents to promote their hydrolysis into conductive surface capping, enabling a certified solar cell efficiency of 18.3%.

Wannier excitons exhibit a relatively large Bohr radius, and this limits the strength of coupling to magnetic ions, in exciton hosting material. Here, Huang et al. overcome this limitation by using self-trapped excitons in Cs₃Cu₂I₅, with a resulting large exciton Zeeman splitting.

The O-alkylation of tertiary alcohols with racemic tertiary electrophiles to access chiral hindered dialkyl ethers has remained elusive. Now this synthetic challenge has been accomplished by copper-catalysed C–O cross-coupling between tertiary haloamides and alcohols using designed ligands.

Although transition metal-catalyzed C–H bond functionalization is a widely used method in organic synthesis, many methods rely on metals of low abundance. Here, the authors report a copper-catalyzed, asymmetric C–H arylation using diaryliodonium salts.

The coffee-ring effect has been a challenge for scalable fabrication and deployment of organic photovoltaics. Here, the authors employ a fluorinated rheology modifier to modulate the rheological properties and improve wettability, achieving an efficiency of 17.85% in green-printed solar modules.

Solid-state lithium batteries typically utilize heterogeneous composite cathodes with conductive additives, which limit energy density and cycle life. Here the authors present a cathode material that exhibits efficient mixed conduction and near-zero volume change during cycling, thereby improving battery performance.

P-Stereogenic organophosphorus compounds are a class of highly important compounds due to their potentials in asymmetric catalysis, both as ligands or catalysts. Here the authors report a regio-, E-, and enantioselective phosphinylation of allenylic acetates with racemic secondary phosphine oxides under bimetallic Pd/Cu catalysis.

CO₂ electroreduction to multicarbon products is desirable but challenging. Now, self-pressurizing nanoscale capsule catalysts are synthesized. The self-pressurising capsules harness high-pressure CO environments for selective acetate or propanol production via a CO–CO₂ coupling pathway.

Neural tissue is a key signalling centre for fundic–antral patterning in development of gastric organoids featuring asymmetric PDX1 patterning.

The realization of free-electron radiation in the terahertz band with both compact device size and tunability is challenging. Here, the authors report an on-chip free-electron Cherenkov radiation source tunable from 3.2 to 14 THz at the microscale.

A core-shell hydride 3CeH₃@BaH₂, which exhibits fast H⁻ conduction at ambient temperature and becomes a superionic conductor above 60 °C, is used to construct an all-solid-state rechargeable H⁻ battery.

Utilizing the immense osmotic energy in membrane separation processes enables spontaneous lithium extraction while generating net energy, offering a promising method for carbon-negative resource recovery.

EpiAgent is a foundation model for analyzing scATAC-seq data that excels in standard downstream tasks such as feature extraction, cell type annotation and data imputation while also enabling simulation of cCRE knockouts and cell state changes.

Diabetic kidney disease (DKD) is the leading cause of end-stage kidney failure. This study shows that prolonged glucagon exacerbates lipid accumulation, promoting renal injury in early DKD, rather than lipid oxidation. Targeting glucagon signaling significantly inhibits DKD progression.

The authors develop a super-gravity field remelting fabrication technology which is effective in synergistically optimizing the electrical and thermal transport properties. Under a super-gravity field, the brittle (Bi,Sb)₂Te₃ alloy undergoes unusual plastic deformation during melt solidification.

Genetic mutations causing hereditary deafness, including autosomal dominant non-syndromic deafness 15 (DFNA15), currently have no effective treatment. Here, authors establish a Pou4f3^WT/Q113* mutant mouse model and engineer and deliver an adenine base editor for near-complete hearing recovery.

The development of Li2S-P2S5 glass ceramics is greatly hampered by the low room temperature lithium conductivity. Here, the authors propose a nanocrystallization strategy to fabricate super lithium conductive glass ceramics.

Replacing animal feathers and wool with synthetic materials can ameliorate the ethical and environmental issues associated with the production of clothing designed to retain warmth. Here the authors present synthetic nanofibre textiles that combine wearability, comfort, lightness and thermal insulation.

The ordering of superstructures plays a critical role in mitigating transition metal migration, voltage decay, and maintaining redox symmetry in Li-rich layered oxides. Here, this study reveals that even in the absence of such superstructure ordering, cathodes can still attain these crucial characteristics.

The study reveals a nanobody that blocks LGR4 to activate fat browning and combat obesity, offering structural insights and a potential strategy for weight loss therapy.

The decarbonization of energy systems requires access to minerals that are critical for manufacturing low-carbon technologies. Here researchers show that meeting climate targets could be impeded by material shortages, revealing the importance of diverse solutions that balance mitigation, equity and resource constraints.

Achieving the modular synthesis of various CF₂-containing building blocks from a single compound remains a formidable challenge. Herein, the authors present a Cu-catalyzed switchable defluoroborylation and hydrodefluorination of trifluoromethylated alkynes, affording four types of synthetically challenging CF₂-containing compounds.

Autonomous artificial intelligence (AI) models to replace human decision-making in medical intervention need thorough testing. Here authors present the results of a clinical trial, NCT05600855, in which daGOAT, a conditional autonomous artificial intelligence agent successfully makes the decision whether to prescribe an immune suppressive drug to prevent severe acute graft-versus-host disease following HLA-mismatched haematopoietic cell transplantation.

Sequencing the genome and microbiome of about 1,500 tick samples from regions across China revealed host–microbe associations in ticks that could have implications for controlling ticks and tick-borne diseases.

Excessive apoptotic cell death and defective efferocytosis drive loss of tolerance and autoimmunity; however, a direct role for macrophage-specific defects in autoimmunity is underexplored. Here, the authors identify macrophage WDFY3 as a negative regulator of autoimmunity by enhancing efferocytosis and reducing MHC-II-mediated antigen presentation, T cell activation, and cytokine dysregulation.

Electrocatalytic C–C coupling has long been viewed as an interfacial process. Now it has been shown that bulk, water-derived redox radicals can mediate C₁ intermediates that migrate to Cu cathodes for C–C coupling, revealing electrolyte redox chemistry as an unanticipated dimension for design in electrocatalysis.

A synthetic biology approach was used to engineer Vibrio natriegens into a strain capable of bioremediating complex organic pollutants in saline wastewater and soils, thereby addressing notable threats to marine biosecurity.

Thin Li foils are desirable for high-energy Li battery applications. Here, Cui and team devise a fabrication route for ultrathin (less than 20 μm) Li foils that show promise for improving existing anodes including silicon, graphite and metallic Li.

Organic radical materials have attracted significant attention for their photophysical properties and potential applications. Here, the authors show by manipulating the n-π* transition and p-π conjugation in a poly(methyl methacrylate) matrix, long-lived excitons and stable radicals can be generated by UV irritation.

Hollow carbon nanospheres form a stable solid electrolyte interphase on lithium metal anodes that suppresses dendrite growth and improves cycling Coulombic efficiency.

Radical methylation ranks among the most important yet challenging transformations in chemistry and biology, which often involves small and unstable radical intermediates, and results in low reactivity and poor selectivity. Herein, the authors report a bioinspired transfer methylation protocol for the direct and selective C(sp²)-H methylation of heteroarenes.

Sonogashira cross-coupling is a powerful strategy to prepare functionalized internal alkynes. Here, the authors report a domino sequence for the generation of γ-/δ-alkynyl nitriles and γ-alkynyl ketones from the coupling of terminal alkynes with O-acyloximes derived from cycloalkanones and acylic ketones, respectively.

The solid-electrolyte interphase is crucial for most batteries, but its characterization is challenging. Here, authors develop a depth-sensitive plasmon-enhanced Raman spectroscopy method to enable in-situ and nondestructive resolving of its structure and chemistry as well as formation mechanisms.