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The authors demonstrated a chiral R-PbI₂ interface in metal halides heterostructure that yields 68% spin-injection efficiency and 29% polarization in photocurrent. This precision engineering provides a vital pathway for efficient opto-spintronics.

RNA polymerase II (RNAPII) is typically considered as an essential enzyme. Here the authors show that natural degradation of RNAPII drives chromatin reorganization in growing oocytes, preparing the chromatin for genome activation after fertilization.

In nasopharyngeal carcinoma (NPC), cisplatin is known to be associated with poor treatment compliance and notable side effects therefore more effective platinum drugs are expected. Here this group updates the 10-year survival analysis results of a multicenter, randomized, phase 3 trial evaluating the efficacy of lobaplatin and fluorouracil induction chemotherapy plus concurrent chemoradiotherapy on 502 NPC patients.

Bacterial phosphate transporter PstSCAB is essential for survival and virulence. Here, authors reveal cryo-EM structures of PstSCAB in multiple states, uncovering how conformational changes drive phosphate import and providing insights for antibiotic development.

Millimeter-wave tunable dielectrics are beneficial for next generation wireless communication technologies. Here, the authors demonstrate that topological polar structures formed in PbTiO₃/SrTiO₃ superlattices exhibit large in-plane dielectric tunability at millimeter-wave frequencies.

Efficient and stable water adsorbents are essential for removing moisture from natural gas and olefins during their production, but industrial desiccants require high regeneration temperatures, while metal-organic frameworks often suffer from limited long-term stability and reusability. Here, the authors introduce a new type of molecular coordination complex desiccants.

Alternative splicing greatly expands the transcriptomic and proteomic diversity in vertebrates. Here, the authors develop a machine-learning tool to identify functional splicing events during hematopoietic cell differentiation, revealing new regulators of hematopoiesis.

Highly ionically conductive and flexible solid-state composite battery electrolytes are engineered by alternately stacking inorganic Li_xM_yPS₃ (M = Cd or Mn) nanosheets with lithium-containing organic polymers in a perpendicular orientation to the surface of the electrodes.

Natural variation in the promoter of OsTPS8 contributes to differences in grain chalkiness and seed vigor between indica and japonica rice subspecies by altering trehalose-6-phosphate biosynthesis and α-amylase levels.

Spin-crossover complexes are promising candidates for molecular bits owing to their magnetic bistability but engineering high-density bits is challenging due to cooperative switching dynamics. Here the authors modulate the cooperative dynamics of surface-confined spin-crossover complex chains.

This work develops an atomic-level coordination engineering strategy that strengthens key intermediate adsorption to promote C–C coupling, enabling highly selective photocatalytic CO₂ conversion to ethylene.

Lipid Nanoparticles (LNPs) effectively deliver mRNA to cells but suffer have low levels of endosomal release. Here the authors report on core-shell LNPs with ionizable lipid–coated gold nanoparticle cores with enhanced pH-responsive membrane disruption, endosomal escape, and cytosolic mRNA delivery improving therapeutic efficiency.

Chen et al. developed a self-powered smart magnetoelastic stent for real-time hemodynamic monitoring and stenosis detection.

In patients with hypopharyngeal squamous cell carcinoma (HPSCC), resistance to the standard-of-care induction chemotherapy often occurs. Here, using longitudinal single-cell transcriptomic profiling of HPSCC samples from patients receiving induction chemotherapy, the authors identify a ZNF683-high natural killer (NK) cell population as a predictor of chemotherapy response.

Multipole datasets and targeted sensitivity simulations reveal interannual variability in Middle Eastern dust accounts for ~36 % of the Indian Ocean Dipole variance during boreal autumn, surpassing the influence of El Niño-Southern Oscillation.

Bioresorbable piezoelectric materials are key for bioelectronic–tissue integration but remain challenging to realize. Here, the authors develop flexible Rochelle salt/PLLA nanofibers that enable effective nerve regeneration and wireless monitoring of intestinal motility.

Genome evolutionary history of wild Arachis species remains unclear. Here, the authors report the origin of small chromosome A08 and genome evolution of Arachis species via comparative oligopainting and genomic analysis of A. hoehnei.

The longevity of leaves determines the overall duration of photosynthesis for plants. This study suggests that climate change drives leaf longevity convergence toward intermediate ranges, which, by altering leaf traits and enhancing photosynthetic capacity, strengthens ecosystem stability and is closely linked to vegetation diversity.

Operating a photonic chip that integrates quantum dots with lithium niobate resonators at an exceptional point allows for spontaneous single-photon emission with an exceptional-point-induced transparency window, a squared-Lorentzian line shape or a Fano-asymmetric line shape.

Here they show that NONO collaborates with HOXA1 to modulate gene expression during early cardiomyocyte differentiation. This interaction facilitates activation of the Wnt signaling pathway, establishing the NONO-HOXA1-Wnt axis as a key mechanism in cardiac development.

Xu et al. report that inhibition of the F-box protein FBXL2 enhances HER2 expression, rendering HER2-negative breast cancer sensitive to the anti-HER2–drug conjugate trastuzumab deruxtecan.

This study elucidates nanoscopic strain evolution in single-crystal Ni-rich positive electrodes, demonstrating that mechanical failure results from lattice distortions, and redefines the roles of cobalt and manganese in battery cycling stability.

Lattice strain impacts battery cathode performance and cycle life. Here, authors visualize and quantify strain in layered oxides through electron backscatter diffraction imaging, revealing heterogeneous, cycle-dependent distortions that slow Li transport and limit capacity, with irreversible layer bending driving capacity fade.

Current lithium-ion batteries still rely heavily on nickel (Ni), whose growing demand raises serious economic and environmental concerns. This work now presents a cathode that delivers longer cycle life than high-Ni chemistry while substantially reducing Ni use.

Behçet’s syndrome is a chronic inflammatory disease with oral ulcers being the most common symptom. Here authors present results from a phase 2 randomized double-blind placebo-controlled clinical trial that shows that systemic low dose interleukin-2 could be safely administered to these patients, and the therapy may improve their quality of life.

Conventional hemodialysis devices are limited by their need for large dialysate volumes, which restricts portability. This study introduces a dialysate-free wearable artificial kidney prototype that uses gas-permeable, blood-repellent membranes for vapor-gradient-driven water removal and integrated adsorption for toxin clearance, offering a promising technology for portable blood purification.

Combining metabolic theory with global datasets, Li et al. show that root water content is a stronger predictor of root growth traits than the widely considered root nitrogen, better reflecting fast acquisition strategies and leaf–root alignment.

The inferior heterojunction quality and misaligned energy levels at the buffer/absorber layer hinders development of antimony selenosulfide solar cells. Here, authors introduce low-work-function tantalum pentoxide dielectric layer for field-effect passivation, achieving device efficiency of 10.95%.

Cryogenic transport measurements of CsV₃Sb₅ nanobeams show a zero-field Josephson diode effect and radio-frequency rectification with power-dependent quantized voltage output.

The authors developed self-incompatible diploid potatoes via haploid breeding. The resulting F₁ hybrids prevent fruit set, redirect photoassimilates to tubers, increase the harvest index and enable scalable hybrid seed production.

The authors consider the changing sensitivity of the leaf-onset date to temperature (S_T) for boreal deciduous broadleaf forests. S_T increased between 1982–1996 and 1998–2012—potentially linked to enhanced chilling accumulation—but this increase is underestimated in phenology models.

Wild relatives of wheat provide a valuable source of genes and allelic variants for wheat improvement. Here, the authors identify a type-B response regulator (RR) AcRR1 from Agropyron cristatum and show its potential of boosting wheat yield by increasing the grain number per spike and promoting early heading.

Topological metamaterial clothing based on metallic conductive textiles can be used to create robust biosensing networks on the human body that can monitor vital signs during exercise.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

Conventional solid-state electrolyte design is limited by dopant–lattice compatibility. This work introduces solid dissociation, using halide van der Waals materials to dissolve salts and create amorphous conductors with high ionic conductivity and potential for use in devices.

A soft, biodegradable, wireless sensing device can monitor pressure, temperature and strain over long distances (up to 16 cm), maintaining accuracy across varying positions and angles.

Intrauterine adhesions (IUA) are a leading cause of female infertility. Here, authors engineer a Tβ4-releasing ECM hydrogel that mimics decidualization to promote endometrial regeneration as a therapeutic strategy for treatment of IUA.

The influence of Li occupancy on electro-chemomechanical stability in Co-free Ni-rich layered oxides for Li-ion batteries has been overlooked. Here, authors investigate different Li structural units in the oxide lattice and show that tuning the Li occupancy improves battery cycling stability.

Genomic analyses of 2,191 global common wheat accessions and over 47,000 yellow rust (YR) response data points across several environments and pathogen races provide a genome-wide landscape of YR resistance genes and effective alleles.