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Redox disruption using electroactive liposome coated gold nanoparticles for cancer therapy

Methods of damaging cancer cells are of therapeutic interest. Here, the authors report on using gold nanoparticles as electron sinks with electroactive bacterial membranes to disrupt cancer cell redox balance, electron transfer induces oxidative stress and triggers cell death by apoptosis.

Ying-Chi Chen
Li-Chan Chang
Chen-Sheng Yeh
ResearchOpen Access05 Apr 2025
Nature Communications

Volume: 16, P: 1-17
Prussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments

Chemodynamic therapy (CDT) uses Fenton chemistry to covert hydrogen peroxide in cancer cells to toxic hydroxyl radicals, but endogenous hydrogen peroxide is insufficient to drive sustainable CDT. Here, the authors report a water oxidation CoFe Prussian blue nanoframe to provide sustained, external energy free self-supply of hydroxyl radicals for CDT.

Liu-Chun Wang
Pei-Yu Chiou
Chen-Sheng Yeh
ResearchOpen Access05 Aug 2023
Nature Communications

Volume: 14, P: 1-16
Atomically dispersed golds on degradable zero-valent copper nanocubes augment oxygen driven Fenton-like reaction for effective orthotopic tumor therapy

Single-atom catalysts emerge as nanocatalytic medicine in chemodynamic therapy but suffer from inefficient kinetics for the production of reactive oxygen species because of the cell’s antioxidative mechanisms. Here, the authors employ a galvanic replacement approach to create atomically dispersed Au on degradable zero-valent Cu nanocubes for tumor treatment.

Liu-Chun Wang
Li-Chan Chang
Chen-Sheng Yeh
ResearchOpen Access15 Dec 2022
Nature Communications

Volume: 13, P: 1-17

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Redox disruption using electroactive liposome coated gold nanoparticles for cancer therapy

Prussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments

Atomically dispersed golds on degradable zero-valent copper nanocubes augment oxygen driven Fenton-like reaction for effective orthotopic tumor therapy

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