Nature Search

A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models

van Lengerich et al. developed a human TREM2 antibody with a transport vehicle (ATV) that improves brain exposure and biodistribution in mouse models. ATV:TREM2 promotes microglial energetic capacity and metabolism via mitochondrial pathways.

Bettina van Lengerich
Lihong Zhan
Kathryn M. Monroe
ResearchOpen Access12 Jan 2023
Nature Neuroscience

Volume: 26, P: 416-429
Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

Wang et al show that microglial NF-κB activation is essential for tau spreading and tau-mediated spatial learning and memory deficits in tauopathy mice. Inactivation of NF-κB reversed tau associated microglial states and rescued autophagy deficits.

Chao Wang
Li Fan
Li Gan
ResearchOpen Access12 Apr 2022
Nature Communications

Volume: 13, P: 1-19
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states

Dräger et al. establish a rapid, scalable platform for iPSC-derived microglia. CRISPRi/a screens uncover roles of disease-associated genes in phagocytosis, and regulators of disease-relevant microglial states that can be targeted pharmacologically.

Nina M. Dräger
Sydney M. Sattler
Martin Kampmann
ResearchOpen Access11 Aug 2022
Nature Neuroscience

Volume: 25, P: 1149-1162
Microglial microRNAs mediate sex-specific responses to tau pathology

Kodama et al. show that microglia from male and female adult mice have distinct microRNA profiles and that loss of microglial microRNAs leads to sex-specific changes in the microglial transcriptome and tau pathology.

Lay Kodama
Elmer Guzman
Li Gan
Research23 Dec 2019
Nature Neuroscience

Volume: 23, P: 167-171
A 60 kd MDM2 isoform is produced by caspase cleavage in non-apoptotic tumor cells

Radhika Pochampally
Brent Fodera
Jiandong Chen
Research19 Oct 1998
Oncogene

Volume: 17, P: 2629-2636
Near infrared emissions from both high efficient quantum cutting (173%) and nearly-pure-color upconversion in NaY(WO₄)₂:Er³⁺/Yb³⁺ with thermal management capability for silicon-based solar cells

The Yb³⁺ emissions from both the quantum cutting and nearly-pure infrared upconversion and excellent temperature detection were realized in Er³⁺/Yb³⁺ co-doped NaY(WO₄)₂ phosphors.

Duan Gao
Baojiu Chen
Lihong Cheng
ResearchOpen Access16 Jan 2024
Light: Science & Applications

Volume: 13, P: 1-14
Development and validation of an Immune-related Gene-based model for predicting prognosis and immunotherapy outcomes in hepatocellular carcinoma patients

Penghui You
Xiaoling Liu
Yi Chen
ResearchOpen Access24 Feb 2025
Scientific Reports

Volume: 15, P: 1-10
Type I interferon signaling facilitates resolution of acute liver injury by priming macrophage polarization

Qiaoling Song
Shyamasree Datta
Jinbo Yang
Research04 Jan 2023
Cellular & Molecular Immunology

Volume: 20, P: 143-157
Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia

Maria A. Telpoukhovskaia
Kai Liu
Li Gan
ResearchOpen Access13 Aug 2020
Scientific Reports

Volume: 10, P: 1-12
MiR-423-5p in brain metastasis: potential role in diagnostics and molecular biology

Guogui Sun
Xiao Ding
LuHua Wang
ResearchOpen Access17 Sept 2018
Cell Death & Disease

Volume: 9, P: 1-15
A high-quality genome assembly of quinoa provides insights into the molecular basis of salt bladder-based salinity tolerance and the exceptional nutritional value

Changsong Zou
Aojun Chen
Heng Zhang
ResearchOpen Access10 Oct 2017
Cell Research

Volume: 27, P: 1327-1340

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