Nature Search

Structure of a protein in a kinetic trap

Qing-Xin Hua
Shai N. Gozani
Michael A. Weiss
Research01 Feb 1995
Nature Structural Biology

Volume: 2, P: 129-138
Pertpy: an end-to-end framework for perturbation analysis

Pertpy serves as a one-stop and performant framework for single-cell perturbation data analysis.

Lukas Heumos
Yuge Ji
Fabian J. Theis
ResearchOpen Access31 Dec 2025
Nature Methods

Volume: 23, P: 350-359
HMGB1 release and redox regulates autophagy and apoptosis in cancer cells

D Tang
R Kang
M T Lotze
Research12 Jul 2010
Oncogene

Volume: 29, P: 5299-5310
Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to altered dysbindin-1 gene expression

Junxia Tang
Robert LeGros
Konrad Talbot
ResearchOpen Access13 Jan 2009
Nature Precedings

P: 1
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Changes in neurotensin signalling drive hedonic devaluation in obesity

In mice, prolonged consumption of a high-fat diet decreases interest in calorie-rich foods as a result of reduced neurotensin expression and signalling, which uncouples hedonic feeding behaviour linked to neurons projecting from lateral nucleus accumbens to ventral tegmental area.

Neta Gazit Shimoni
Amanda J. Tose
Stephan Lammel
ResearchOpen Access26 Mar 2025
Nature

Volume: 641, P: 1238-1247
The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

GDF15 has potent anti-obesity effects, but its receptor was previously unknown. GFRAL has now been identified as the receptor for GDF15, and it mediates the effects of GDF15 via central actions in the hindbrain.

Paul J Emmerson
Feng Wang
Xinle Wu
Research28 Aug 2017
Nature Medicine

Volume: 23, P: 1215-1219
Potentiation of cortico-spinal output via targeted electrical stimulation of the motor thalamus

Cerebral lesions result in loss of upper-limb motor functions. Here, the authors show that electrical stimulation of the motor thalamus can immediately and significantly improve strength and volitional force control improving arm and hand functions.

Jonathan C. Ho
Erinn M. Grigsby
Elvira Pirondini
ResearchOpen Access01 Oct 2024
Nature Communications

Volume: 15, P: 1-21
Lipid phosphatases as drug discovery targets for type 2 diabetes

The worldwide incidence of type 2 diabetes has reached epidemic proportions. More effective pharmaceutical options for the treatment of this devastating and costly disease are urgently needed. Dan Lazar and Alan Saltiel examine the exciting possibility that lipid phosphatases might provide a novel class of drug discovery targets for type 2 diabetes.

Dan F. Lazar
Alan R. Saltiel
Reviews01 Apr 2006
Nature Reviews Drug Discovery

Volume: 5, P: 333-342
Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

Progressive diseases tend to be heterogeneous in their underlying aetiology mechanism, disease manifestation, and disease time course. Here, Young and colleagues devise a computational method to account for both phenotypic heterogeneity and temporal heterogeneity, and demonstrate it using two neurodegenerative disease cohorts.

Alexandra L Young
Razvan V Marinescu
Ansgar J Furst
ResearchOpen Access15 Oct 2018
Nature Communications

Volume: 9, P: 1-16
Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

Honor Bixby
James Bentham
Majid Ezzati
ResearchOpen Access08 May 2019
Nature

Volume: 569, P: 260-264
Correction: HMGB1 release and redox regulates autophagy and apoptosis in cancer cells

D. Tang
R. Kang
M. T. Lotze
Amendments and Corrections24 Jul 2025
Oncogene

Volume: 44, P: 2927-2928
The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

The Microarray Quality Control consortium pitted 36 teams against each other to evaluate methods for creating genomic classifiers, computational tools for interpreting gene expression profiles. The performance of the classifiers on blinded validation data—and metadata on the analytic methods—reveal the challenges facing the field.

Leming Shi
Gregory Campbell
Russell D Wolfinger
Research30 Jul 2010
Nature Biotechnology

Volume: 28, P: 827-838
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus–related hepatocellular carcinoma

Long Yu and colleagues report a genome-wide association study for hepatitis B virus–related hepatocellular carcinoma (HBV-HCC). They report that genetic variants in STAT4 and HLA-DQ genes confer risk of HBV-HCC.

De-Ke Jiang
Jielin Sun
Long Yu
Research16 Dec 2012
Nature Genetics

Volume: 45, P: 72-75
Is There a Relationship between Baseline and Treatment-Associated Changes in [³H]-IMI Platelet Binding and Clinical Response in Major Depression?

Gary D. Tollefson
John H. Heiligenstein
Charles B. Nemeroff
Research01 Jan 1996
Neuropsychopharmacology

Volume: 14, P: 47-53
Chinese scientists and US leadership in the life sciences

Steven H. Holtzman
Ron Cohen
Shuguang Zhang
Correspondence03 Oct 2019
Nature Biotechnology

Volume: 37, P: 1261-1263
Genomic analysis of early-stage lung cancer reveals a role for TP53 mutations in distant metastasis

Debra Van Egeren
Khushi Kohli
Zenta Walther
ResearchOpen Access09 Nov 2022
Scientific Reports

Volume: 12, P: 1-6

Search

Structure of a protein in a kinetic trap

Pertpy: an end-to-end framework for perturbation analysis

HMGB1 release and redox regulates autophagy and apoptosis in cancer cells

Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to altered dysbindin-1 gene expression

Diminishing benefits of urban living for children and adolescents’ growth and development

Changes in neurotensin signalling drive hedonic devaluation in obesity

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

Potentiation of cortico-spinal output via targeted electrical stimulation of the motor thalamus

Lipid phosphatases as drug discovery targets for type 2 diabetes

Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Correction: HMGB1 release and redox regulates autophagy and apoptosis in cancer cells

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus–related hepatocellular carcinoma

Is There a Relationship between Baseline and Treatment-Associated Changes in [³H]-IMI Platelet Binding and Clinical Response in Major Depression?

Chinese scientists and US leadership in the life sciences

Genomic analysis of early-stage lung cancer reveals a role for TP53 mutations in distant metastasis

Search

Quick links

Search

Filter By:

Search

Quick links