Nature Search

Transposable element expression and sub-cellular dynamics during hPSC differentiation to endoderm, mesoderm, and ectoderm lineages

Transposable elements are genetic parasites that have colonised genomes and they express as parts of coding and noncoding RNAs. Here, the authors explore how they are expressed in transcripts in normal human development, and how they alter transcript dynamics.

Isaac A. Babarinde
Xiuling Fu
Andrew P. Hutchins

ResearchOpen Access18 Aug 2025

Nature Communications

Volume: 16, P: 1-24

Immunotherapy and senolytics in head and neck squamous cell carcinoma: phase 2 trial results

Two phase 2 trials, along with translational analysis of prospective cohorts and experimental analysis, indicate that immunosenescence as a mechanism of resistance to immunotherapy can be overcome with the senolytics dasatinib and quercetin in patients with head and neck squamous cell carcinoma.

Niu Liu
Jiaying Wu
Song Fan

Research25 Aug 2025

Nature Medicine

Volume: 31, P: 3047-3061

Regulatory controls of duplicated gene expression during fiber development in allotetraploid cotton

Genome and transcriptome analyses of 376 Gossypium hirsutum accessions uncover the regulation of gene expression during fiber development in allotetraploid cotton and highlight the potential for fiber quality improvement.

Jiaqi You
Zhenping Liu
Maojun Wang

ResearchOpen Access16 Oct 2023

Nature Genetics

Volume: 55, P: 1987-1997

Optical and Electrical Properties of Multi-Walled Carbon Nanotubes Functionalized with Oxadiazole Chromophores

Bo-Zhang Yu
Ji-Fei Ma
Wen-Xin La

ResearchOpen Access07 Jan 2009

Nature Precedings

P: 1

Histone lactylation promotes multidrug resistance in hepatocellular carcinoma by forming a positive feedback loop with PTEN

Yuan Zeng
Haoran Jiang
Fujun Yu

ResearchOpen Access31 Jan 2025

Cell Death & Disease

Volume: 16, P: 1-16

Clonal hematopoiesis related TET2 loss-of-function impedes IL1β-mediated epigenetic reprogramming in hematopoietic stem and progenitor cells

The expansion of cells with TET2 mutations within the blood is associated with increased risk for all-cause mortality, development of leukemia and cardiovascular disease. Here authors show IL1 promotes the clonal expansion TET2 knockout cells, enhancing their self-renewal, promoting their myeloid bias and impairing an IL1 driven loss of methylation at lymphoid and erythroid regulatory elements.

J. McClatchy
R. Strogantsev
A. Agarwal

ResearchOpen Access07 Dec 2023

Nature Communications

Volume: 14, P: 1-17

Elucidating university students’ intentions to seek automated writing feedback from Grammarly: toward perceptual and systemic predictors

Yupeng Lin
Zhonggen Yu

ResearchOpen Access18 Aug 2025

Humanities and Social Sciences Communications

Volume: 12, P: 1-17

Effect of p21Waf1 and p27Kip1 on centrosome replication and proliferation of breast cancer cell

Fu-Nian Li
Dan-Dan Jiang
Xin-Gang Wang

ResearchOpen Access10 May 2010

Nature Precedings

P: 1

Author Correction: HC-Pro inhibits HEN1 methyltransferase activity, leading to autophagic degradation of AGO1

Zhao-Jun Pan
Wei-Lun Wei
Shih-Shun Lin

Amendments and CorrectionsOpen Access30 Jul 2025

Nature Communications

Volume: 16, P: 1

An AIoT enabled system for optimizing data retrieval in the intensive care unit evaluated in a randomized crossover pilot trial

How‑Yang Tseng
Wen-Sheng Feng
Der-Yang Cho

ResearchOpen Access09 Oct 2025

Scientific Reports

Volume: 15, P: 1-12

Precise detection of tiny birefringence with accuracy reaching 10⁻¹¹ level

The authors demonstrate that high-precision birefringence detection at the 10⁻¹¹ level can be achieved using spin-orbit-coupled Rabi oscillations in a photonic two-level system. The presented detection technique benefits a broad range of applications involving optical birefringence such as precise control of the entangled photonic states.

Xiliang Zhang
Yanwen Hu
Shenhe Fu

ResearchOpen Access11 Jul 2025

Nature Communications

Volume: 16, P: 1-12

Inhibition of tumor growth and metastasis with antisense oligonucleotides (Cantide) targeting hTERT in an in situ human hepatocellular carcinoma model

Ru-xian Lin
Chao-wei Tuo
Sheng-qi Wang

Research01 Jun 2005

Acta Pharmacologica Sinica

Volume: 26, P: 762-768

Hypermethylation-mediated HNF4A silencing by Helicobacter pylori infection drives gastric cancer by disrupting epithelial cell polarity and activating EMT signaling

Dandan Li
Zeng Zhou
Shanshan Qin

ResearchOpen Access06 Oct 2025

Cell Death & Disease

Volume: 16, P: 1-15

Overexpression of DHX32 contributes to the growth and metastasis of colorectal cancer

Huayue Lin
Wenjuan Liu
Zhong-Ying Zhang

ResearchOpen Access18 Mar 2015

Scientific Reports

Volume: 5, P: 1-7

A noninvasive model for chronic kidney disease screening and common pathological type identification from retinal images

The diagnosis and prognosis of chronic kidney disease (CKD) relies on invasive renal biopsies, which can be clinically constrained. Here, the authors develop a non-invasive model using retinal images that can be used to screen for CKD and identify five common pathological types of CKD.

Qianni Wu
Jianbo Li
Haotian Lin

ResearchOpen Access29 Jul 2025

Nature Communications

Volume: 16, P: 1-15

Unconventional phase metal heteronanostructures with tunable exposed interface for efficient tandem nitrate electroreduction to ammonia

Tandem catalysts are important in electrocatalysis but suffer from uncontrollable interfaces, limited crystal phases, and complex synthesis. Here, the authors report the facile synthesis of hetero-phase 4H/fcc Au–Cu tandem catalysts with tunable interfaces for ammonia electrosynthesis from nitrate.

Yangbo Ma
Liang Guo
Zhanxi Fan

ResearchOpen Access16 Aug 2025

Nature Communications

Volume: 16, P: 1-14

Biomarkers of pediatric Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis through single-cell transcriptomics

Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a life-threatening condition different from self-limiting nature of Epstein-Barr virus-induced infectious mononucleosis (IM). Here the authors identify IDO1⁺ monocytes and L-kynurenine as biomarkers for HLH by comparing single cell sequencing data of HLH patients with IM and healthy volunteers as the controls.

Jie Shen
Yunyan He
Minghua Yang

ResearchOpen Access25 Jul 2025

Nature Communications

Volume: 16, P: 1-21

Stromal FOXF2 suppresses prostate cancer progression and metastasis by enhancing antitumor immunity

Forkhead transcription factor FoxF2 plays a crucial role in the development of organs derived from primitive gut. Here the authors show that reduction of Foxf2 expression in stromal cells is associated with high grade prostate cancer and that increasing prostatic stromal Foxf2 sensitizes prostate cancer to immune checkpoint blockade.

Deyong Jia
Zhicheng Zhou
Li Xin

ResearchOpen Access11 Nov 2022

Nature Communications

Volume: 13, P: 1-18

An unbiased proteomic platform for ATE1-based arginylation profiling

Arginylation is a post-translational modification that is difficult to distinguish from arginine residues using mass spectrometry. Now a method has been developed to profile protein arginylation ex vivo and is tested on different samples, revealing 235 unique arginylation sites in the human proteomes.

Zongtao Lin
Yixuan Xie
Benjamin A. Garcia

ResearchOpen Access25 Aug 2025

Nature Chemical Biology

P: 1-11

Author Correction: Plants interfere with non-self recognition of a phytopathogenic fungus via proline accumulation to facilitate mycovirus transmission

Du Hai
Jincang Li
Jiatao Xie

Amendments and CorrectionsOpen Access11 Aug 2025

Nature Communications

Volume: 16, P: 1

DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death

Chemoresistance is one of the main challenges for cancer therapy success. Here, the authors show that dual-specificity phosphatase 16 (DUSP16) expression is associated with chemoresistance in several types of cancer through impairing mitochondria-associated apoptosis.

Heng Boon Low
Zhen Lim Wong
Yongliang Zhang

ResearchOpen Access16 Apr 2021

Nature Communications

Volume: 12, P: 1-16

Axin determines cell fate by controlling the p53 activation threshold after DNA damage

The tumour suppressor p53 induces either apoptosis or cell-cycle arrest upon genotoxic stress. A regulatory network based on a complex of p53, the signalling protein axin, the p53 kinase HIPK2, the DNA repair-associated acetyltransferase Tip60 and Pirh2 governs the cellular response to p53 activation.

Qinxi Li
Shuyong Lin
Sheng-Cai Lin

Research23 Aug 2009

Nature Cell Biology

Volume: 11, P: 1128-1134

Enhancing diagnostic accuracy in rare and common fundus diseases with a knowledge-rich vision-language model

Previous ophthalmic foundation models have struggled to generalize effectively to diverse and rare fundus diseases, restricting their clinical applicability. Here, the authors introduce a vision-language foundation model that demonstrates superior performance in diagnosing both common and rare fundus conditions.

Meng Wang
Tian Lin
Huazhu Fu

ResearchOpen Access01 Jul 2025

Nature Communications

Volume: 16, P: 1-17

Analysis of diagnostic apoptosis-related biomarkers and immune cell infiltration characteristics in endometriosis by integrating bioinformatics and machine learning

Xiulan Weng
Jingxuan Ye
Pengming Sun

ResearchOpen Access29 Sept 2025

Scientific Reports

Volume: 15, P: 1-13

Regional differences and dynamic evolution of quality medical resources in Chongqing, China

Jiale Liao
Qianyu Jiang
Lin Luo

ResearchOpen Access30 Sept 2025

Humanities and Social Sciences Communications

Volume: 12, P: 1-16

Relationship between neuropsychiatric symptoms and social support in older adults with mild behavioral impairment: a moderated mediation model

Yanhong Shi
Zixin Fang
Hong Li

ResearchOpen Access25 Sept 2025

Scientific Reports

Volume: 15, P: 1-10

Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment

Giafaglione et al. define metabolic regulation of prostate epithelial lineage identity and show that modulation of lactate metabolism alters response to antiandrogen therapy.

Jenna M. Giafaglione
Preston D. Crowell
Andrew S. Goldstein

ResearchOpen Access04 Dec 2023

Nature Cell Biology

Volume: 25, P: 1821-1832

Research on the co-occurrence feature mining of the Qing Dynasty embroidery patterns based on temporal multilayer networks

Yu Zhang
Haiying Zhao
Tian Zhang

ResearchOpen Access03 Jun 2025

npj Heritage Science

Volume: 13, P: 1-19

A single mutation may contribute to accelerated evolution of SARS-CoV-2 toward Omicron

Drivers of viral evolution in SARS-CoV-2 are insufficiently understood. In this study, the authors show how a key SARS-CoV-2 mutation, NSP4 T492I, is potentially responsible for accelerating genome evolution to develop adaptive variants (e.g. Omicron).

Xiaoyuan Lin
Zhou Sha
Zhenglin Zhu

ResearchOpen Access29 Jul 2025

Nature Communications

Volume: 16, P: 1-18

STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity

Immune checkpoint blockade activates T cell immunity by reprogramming the STAT3 and STAT5 transcriptional pathways in dendritic cells, and STAT3 degradation is effective for treating tumours of multiple cancer types in mouse models.

Jiajia Zhou
Kole Tison
Weiping Zou

ResearchOpen Access14 May 2025

Nature

Volume: 643, P: 519-528

Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations

The compassionate use of l-asparaginase in patients suffering from nasopharyngeal carcinoma substantially strengthens the efficacy of immune-checkpoint blockade therapy by enhancing T cell fitness.

Hsuan-Chia Chang
Chung-Ying Tsai
Huang-Yu Yang

ResearchOpen Access05 Mar 2025

Nature Metabolism

Volume: 7, P: 918-927

Atomic-scale visualization of strain-tailored noncollinear spin textures in an antiferromagnetic ultrathin film

Antiferromagnets have intrinsic robustness to external perturbations, and while useful for device miniaturization, it makes manipulation of antiferromagnetic spins and ordering challenging. Here, Chen, Drevelow and coauthors successfully image the strain induced transformation of noncollinear antiferromagnetic order in a manganese bilayer.

Chia-Ju Chen
Tim Drevelow
Pin-Jui Hsu

ResearchOpen Access11 Aug 2025

Nature Communications

Volume: 16, P: 1-11

Secretogranin 2 binds LILRB4 resulting in immunosuppression

Here the authors identify the granin hormone SCG2 as a ligand for the inhibitory receptor LILRB4. They show that SCG2 released from tumors can suppress antitumor immune responses via this interaction, indicating possible therapeutic strategies.

Xing Yang
Ryan Huang
Cheng Cheng Zhang

Research24 Jul 2025

Nature Immunology

Volume: 26, P: 1567-1580

A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway

Kent Nybakken
Steven A Vokes
Norbert Perrimon

Research20 Nov 2005

Nature Genetics

Volume: 37, P: 1323-1332

Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor

Abudumijiti Abulizi
Ling Hu
Bao-xue Yang

Research29 Apr 2021

Acta Pharmacologica Sinica

Volume: 42, P: 1703-1713

PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death

Shuiping Liu
Haoming Lin
Xinbing Sui

ResearchOpen Access29 Nov 2019

Signal Transduction and Targeted Therapy

Volume: 4, P: 1-10

A phase III clinical trial of monthly minodronate in the treatment of Chinese postmenopausal women with osteoporosis

Hao Zhang
Ya-nan Huo
Zhen-lin Zhang

Research01 Oct 2025

Acta Pharmacologica Sinica

P: 1-8

Photocatalytic ethylene production over defective NiO through lattice oxygen participation

This paper reports engineering of metal vacancy to activate lattice oxygen in NiO, enabling photocatalytic ethane dehydrogenation to ethylene at 604.5 μmol g⁻¹ h⁻¹ with 100% selectivity and stable 200-cycle recyclability via a light-enhanced Mars-van Krevelen mechanism.

Fen Wei
Jiwu Zhao
Sibo Wang

ResearchOpen Access17 Jul 2025

Nature Communications

Volume: 16, P: 1-10

Mesozoic and Cenozoic evolution of the North and South China blocks (reply)

JIN-LU LIN
M. FULLER

Research06 Mar 1986

Nature

Volume: 320, P: 87

Comprehensive and clinically accurate head and neck cancer organs-at-risk delineation on a multi-institutional study

Accurate organ at risk (OAR) segmentation is critical to reduce the radiotherapy post-treatment complications. Here, the authors develop an automated OAR segmentation system to delineate a comprehensive set of 42 H&N OARs.

Xianghua Ye
Dazhou Guo
Tsung-Ying Ho

ResearchOpen Access17 Oct 2022

Nature Communications

Volume: 13, P: 1-15

Alveolar epithelial cells mitigate neutrophilic inflammation in lung injury through regulating mitochondrial fatty acid oxidation

Impaired mitochondrial long-chain fatty acid β-oxidation (mtLCFAO) in type 2 alveolar epithelial (AT2) cells is thought to aggravate alveolar inflammation in acute lung injury. Here, the authors show that the mtLCFAO rate limiting enzyme CPT1a is decreased in AT2 cells in acute respiratory distress syndrome, highlighting the role of mtLCFAO in immunometabolism in this context.

Kuei-Pin Chung
Chih-Ning Cheng
Chong-Jen Yu

ResearchOpen Access22 Aug 2024

Nature Communications

Volume: 15, P: 1-23

A lysosomal surveillance response to stress extends healthspan

Li et al. uncover a lysosomal surveillance response whereby intestinal lumen deacidification induces a transcriptional programme that boosts lysosomal activity and improves protein aggregate clearance in multiple worm disease models, extending healthspan.

Terytty Yang Li
Arwen W. Gao
Johan Auwerx

ResearchOpen Access26 Jun 2025

Nature Cell Biology

Volume: 27, P: 1083-1097

A cost-effective all-in-one halide material for all-solid-state batteries

A cost-effective all-in-one halide cathode material with high energy density and exceptional cycling stability can be used to achieve energy-dense, durable cathodes for the next generation of all-solid-state batteries.

Jiamin Fu
Changhong Wang
Xueliang Sun

Research25 Jun 2025

Nature

Volume: 643, P: 111-118

Shifting hotspot of tropical cyclone clusters in a warming climate

Tropical cyclones can occur concurrently in the same basins in clusters, potentially resulting in greater damage. Here the authors show that global warming causes a shift in hotspots of such clusters towards the North Atlantic.

Zheng-Hang Fu
Dazhi Xi
Johnny C. L. Chan

ResearchOpen Access31 Jul 2025

Nature Climate Change

Volume: 15, P: 850-858

A universal and versatile terahertz field manipulation mechanism by manipulating near-infrared phases with a dislocation scheme

A universal and versatile terahertz wavefront-phase manipulation is proposed and confirmed experimentally by manipulating two-dimensionally phases of the near-infrared pulses and converting them to terahertz region by nonlinear difference frequency.

Qinggang Lin
Fu Feng
Xiaocong Yuan

ResearchOpen Access19 Jul 2025

Nature Communications

Volume: 16, P: 1-9

Association of fine particulate matter and wet-bulb globe temperature with depression incidence in a community-based longitudinal study

Ta-Jen Lin
Fu-Wen Liang
Jiun-Hung Geng

ResearchOpen Access29 Sept 2025

Scientific Reports

Volume: 15, P: 1-10

The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease

Susan E. Andrew
Y. Paul Goldberg
Michael R. Hayden

Research01 Aug 1993

Nature Genetics

Volume: 4, P: 398-403

Combination of fucoidan-based magnetic nanoparticles and immunomodulators enhances tumour-localized immunotherapy

Magnetic fucoidan-based nanoparticles conjugated with T-cell activators and checkpoint inhibitors can be directed to tumours via magnetic navigation for improving therapeutic efficacy and reducing systemic side effects.