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Showing 1–2 of 2 results
Advanced filters: Author: Lin-Xin Ruan Clear advanced filters

  • A N-heterocyclic carbene–nickel-catalysed dynamic kinetic asymmetric aldehyde–alkyne reductive coupling reaction is reported, achieving control over chemo-, regio-, E/Z-, diastereo-, and enantioselectivity. This approach offers a streamlined route to construct multifunctional allylic alcohols with adjacent stereocentres from readily accessible substrates.

    • Guang Chen
    • Jia-Ming Liu
    • Shi-Liang Shi
    Research
    Nature Synthesis
    P: 1-10

  • The synthesis of α,β-stereogenic tertiary alcohols featuring multiple contiguous stereocentres is a challenge. Now, a method for the enantioconvergent copper-catalysed allylation, propargylation and crotylation of racemic ketones is reported. The process provides access to chiral tertiary alcohols bearing multiple contiguous stereocentres.

    • Bo Sun
    • Lin-Xin Ruan
    • Shi-Liang Shi
    Research
    Nature Synthesis
    Volume: 3, P: 1091-1103