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Showing 1–4 of 4 results
Advanced filters: Author: Lior Roitman Clear advanced filters

  • Elyahu and colleagues describe the reciprocal interplay between senescent cells (SCs) and a helper T cell population that accumulates during aging. They show that selective depletion of this T cell population increases SC accumulation, accelerates frailty and limits lifespan in mice.

    • Yehezqel Elyahu
    • Ilana Feygin
    • Alon Monsonego
    Research
    Nature Aging
    Volume: 5, P: 1970-1982

  • Majewska et al. show that p16-expressing senescent cells enhance the stability of the immune checkpoint PD-L1 by downregulating its proteasome-mediated ubiquitin-dependent degradation, leading to their accumulation in ageing and chronic inflammation.

    • Julia Majewska
    • Amit Agrawal
    • Valery Krizhanovsky
    ResearchOpen Access
    Nature Cell Biology
    Volume: 26, P: 1336-1345

  • HLA peptidomic analysis identifies recurrent intracellular bacteria-derived peptides presented on HLA-I and HLA-II molecules in melanoma tumours, revealing how bacteria can modulate immune functions and responses to cancer therapies.

    • Shelly Kalaora
    • Adi Nagler
    • Yardena Samuels
    Research
    Nature
    Volume: 592, P: 138-143

  • Synthetic biology and engineering approaches are harnessed to incorporate new capabilities in synthetic cells. Here, the authors designed bioluminescent signaling mechanisms for intracellular and intercellular synthetic-to-natural cell communication.

    • Omer Adir
    • Mia R. Albalak
    • Avi Schroeder
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13