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Advanced filters: Author: Liran Mao Clear advanced filters

Spatial profiling of chromatin accessibility in formalin-fixed paraffin-embedded tissues

FFPE tissues are widely used to preserve clinical specimens, but formalin-induced crosslinking limits their use in epigenomic profiling. Here, the authors present spatial FFPE-ATACseq, enabling in situ chromatin accessibility mapping while preserving tissue architecture in archived samples.

Pengfei Guo
Yufan Chen
Yanxiang Deng
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-11
Multiplexed spatial mapping of chromatin features, transcriptome and proteins in tissues

Spatial-Mux-seq offers a multimodal spatial platform capable of profiling multiple molecular modalities, including the transcriptome, chromatin accessibility, histone modifications and targeted proteins.

Pengfei Guo
Liran Mao
Yanxiang Deng
Research27 Jan 2025
Nature Methods

Volume: 22, P: 520-529
Whole genome sequencing and structural variations provide insights into the body size traits of Hu sheep

Xin Xiang
Yujiao Guo
Zhengguang Wang
ResearchOpen Access06 Aug 2025
Scientific Data

Volume: 12, P: 1-9