Nature Search

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Epstein–Barr virus–driven gene therapy for EBV–related lymphomas

Michael Franken
Anita Estabrooks
David T. Scadden
Research01 Dec 1996
Nature Medicine

Volume: 2, P: 1379-1382
Evidence for a mechanism predisposing to intergenerational CAG repeat instability in spinocerebellar ataxia type I

Ming-yi Chung
Laura P.W. Ranum
Harry T. Orr
Research01 Nov 1993
Nature Genetics

Volume: 5, P: 254-258
Isolation of a GCC repeat showing expansion in FRAXF, a fragile site distal to FRAXA and FRAXE

Julia E. Parrish
Ben A. Oostra
David L. Nelson
Research01 Nov 1994
Nature Genetics

Volume: 8, P: 229-235
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Genome-wide association study of long COVID

A genome-wide study by the Long COVID Host Genetics Initiative identifies an association between the FOXP4 locus and long COVID, implicating altered lung function in its pathophysiology.

Vilma Lammi
Tomoko Nakanishi
Hanna M. Ollila
ResearchOpen Access21 May 2025
Nature Genetics

Volume: 57, P: 1402-1417
Identification of female carriers for Duchenne and Becker muscular dystrophies using a FISH-based approach

Azra H Ligon
Catherine D Kashork
Lisa G Shaffer
Research15 Jun 2000
European Journal of Human Genetics

Volume: 8, P: 293-298
Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1

Harry T. Orr
Ming-yi Chung
Huda Y. Zoghbi
Research01 Jul 1993
Nature Genetics

Volume: 4, P: 221-226
The prognostic value of N-terminal proB-type natriuretic peptide

The roles of N-terminal proBNP, an inactive amino acid product of BNP prohormone cleavage, seem to be many-fold in heart disease. Here, Lisa C Costello-Boerrigter and John C Burnett Jr explore some of the ways in which this biomarker can aid diagnosis and prediction of prognosis in various cardiovascular diseases.

Lisa C Costello-Boerrigter
John C Burnett Jr
Reviews01 Apr 2005
Nature Clinical Practice Cardiovascular Medicine

Volume: 2, P: 194-201
Learning outcomes and evaluation metrics for training researchers to engage in science policy

K. L. Akerlof
Todd Schenk
Anne-Lise K. Velez
ResearchOpen Access21 Jul 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-16
Neurodevelopmental effects of the FMR-1 full mutation in humans

Allan L. Reiss
Michael T. Abrams
Martha B. Denckla
Research01 Feb 1995
Nature Medicine

Volume: 1, P: 159-167
Defective acidification of intracellular organelles in cystic fibrosis

Jonathan Barasch
Brian Kiss
Qais AI-Awqati
Research04 Jul 1991
Nature

Volume: 352, P: 70-73
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Land-use choices follow profitability at the expense of ecological functions in Indonesian smallholder landscapes

Small-scale farmers in Southeast Asia are increasingly turning to monocultures of oil palm and rubber to maximize income. Clough and colleagues demonstrate that this land-use change in Indonesia comes at a cost to a wide array of ecosystem functions and biodiversity.

Yann Clough
Vijesh V. Krishna
Stefan Scheu
ResearchOpen Access11 Oct 2016
Nature Communications

Volume: 7, P: 1-12
The Gulf Stream moved northward at the end of the Little Ice Age

The Gulf Stream was positioned further south during the Little Ice Age than today as a result of strengthened Labrador and Deep Western Boundary Currents and negative North Atlantic Oscillation, according to a high-resolution magnesium record from a Bermudan stalagmite

Edward C. G. Forman
James U. L. Baldini
Andrew J. Peters
ResearchOpen Access14 Jul 2025
Communications Earth & Environment

Volume: 6, P: 1-11
Development of genomic reference materials for Huntington disease genetic testing

Lisa Kalman
Monique A Johnson
C Sue Richards
Research01 Oct 2007
Genetics in Medicine

Volume: 9, P: 719-723
Large-scale migration into Britain during the Middle to Late Bronze Age

Genome-wide ancient DNA data from individuals from the Middle Bronze Age to Iron Age documents large-scale movement of people from the European continent between 1300 and 800 bc that was probably responsible for spreading early Celtic languages to Britain.

Nick Patterson
Michael Isakov
David Reich
Research22 Dec 2021
Nature

Volume: 601, P: 588-594
Understanding CCMs

Lisa Richards
Research Highlights01 Apr 2009
Nature Reviews Neurology

Volume: 5, P: 180
Apparent protection from instability of repeat sequences in cancer-related genes in replication error positive gastrointestinal cancers

Lisa A Simms
Tong-Tong Zou
Barbara A Leggett
Research29 May 1997
Oncogene

Volume: 14, P: 2613-2618
Strontium isoscape of sub-Saharan Africa allows tracing origins of victims of the transatlantic slave trade

Strontium isotope analysis can be applied to animal and plant tissues to help determine their provenance. Here, the authors generate a strontium isoscape of sub-Saharan Africa using data from 2266 environmental samples and demonstrate its efficacy by tracing the African roots of individuals from historic slavery contexts.

Xueye Wang
Gaëlle Bocksberger
Vicky M. Oelze
ResearchOpen Access30 Dec 2024
Nature Communications

Volume: 15, P: 1-14
Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Research06 May 2020
Nature

Volume: 583, P: 90-95
Adeno-associated virus 2 infection in children with non-A–E hepatitis

A case–control study investigating the causes of recent cases of acute hepatitis of unknown aetiology in 32 children identifies an association between adeno-associated virus infection and host genetics in disease susceptibility.

Antonia Ho
Richard Orton
Emma C. Thomson
Research30 Mar 2023
Nature

Volume: 617, P: 555-563
Genome-wide association study identifies 30 loci associated with bipolar disorder

Genome-wide analysis identifies 30 loci associated with bipolar disorder, allowing for comparisons of shared genes and pathways with other psychiatric disorders, including schizophrenia and depression.

Eli A. Stahl
Gerome Breen
Pamela Sklar
Research01 May 2019
Nature Genetics

Volume: 51, P: 793-803
Liver-transplantation outcomes poor for IFN-treated patients with HCV

Lisa Richards
Research Highlights01 Apr 2009
Nature Reviews Gastroenterology & Hepatology

Volume: 6, P: 194
Carbohydrate malabsorption in chronic intestinal disorders

Lisa Richards
Research Highlights01 Sept 2009
Nature Reviews Gastroenterology & Hepatology

Volume: 6, P: 501
Ejection fraction and risk prediction

Lisa Richards
Research Highlights01 Sept 2009
Nature Reviews Cardiology

Volume: 6, P: 559
A new therapeutic target for advanced thyroid cancer

Lisa Richards
Research Highlights01 Jul 2009
Nature Reviews Endocrinology

Volume: 5, P: 357
Obesity during childhood and adolescence: genes versus environment

Lisa Richards
Research Highlights01 Aug 2009
Nature Reviews Endocrinology

Volume: 5, P: 413
N-cadherin—a target for prostate cancer therapy

Lisa Richards
Research Highlights31 Jan 2011
Nature Reviews Clinical Oncology

Volume: 8, P: 63
Biomarkers of chemotherapy response in breast cancer

Lisa Richards
Research Highlights01 May 2010
Nature Reviews Clinical Oncology

Volume: 7, P: 241
ALL: reducing cardiomyopathy

Lisa Richards
Research Highlights29 Nov 2010
Nature Reviews Clinical Oncology

Volume: 7, P: 673
Intravesical MCC for bladder cancer

Lisa Richards
Research Highlights01 May 2009
Nature Reviews Urology

Volume: 6, P: 241
Acute lymphoblastic leukemia—potential therapeutic targets

Lisa Richards
Research Highlights01 Jul 2010
Nature Reviews Clinical Oncology

Volume: 7, P: 357
Infertility and cancer

Lisa Richards
Research Highlights01 May 2009
Nature Reviews Urology

Volume: 6, P: 242
Genetic risk factors in type 2 diabetes mellitus

Lisa Richards
Research Highlights01 Aug 2009
Nature Reviews Endocrinology

Volume: 5, P: 414
C3 genotyping of no benefit in renal transplants

Lisa Richards
Research Highlights01 May 2009
Nature Reviews Nephrology

Volume: 5, P: 245
HER3 overexpression in breast cancer conveys a poor prognosis

Lisa Richards
Research Highlights01 Aug 2010
Nature Reviews Clinical Oncology

Volume: 7, P: 423
Amelioration of risk by omega-3 modified by COX-2

Lisa Richards
Research Highlights01 May 2009
Nature Reviews Urology

Volume: 6, P: 240
Use sorafenib first in sequential TKI regimens

Lisa Richards
Research Highlights01 Aug 2009
Nature Reviews Urology

Volume: 6, P: 408
Marijuana use linked with testicular cancer

Lisa Richards
Research Highlights01 Apr 2009
Nature Reviews Urology

Volume: 6, P: 180
Protein content of infant formula linked to obesity risk

Lisa Richards
Research Highlights01 Aug 2009
Nature Reviews Endocrinology

Volume: 5, P: 415
Kidneys from old donors: tackling the organ shortage

Lisa Richards
Research Highlights01 Sept 2009
Nature Reviews Nephrology

Volume: 5, P: 488
Mutation status and treatment response

Lisa Richards
Research Highlights01 Jul 2009
Nature Reviews Clinical Oncology

Volume: 6, P: 374
A new method for predicting metastasis in sarcomas

Lisa Richards
Research Highlights29 Sept 2010
Nature Reviews Clinical Oncology

Volume: 7, P: 551
IL-3 prevents inflammatory arthritis

Lisa Richards
Research Highlights01 Apr 2009
Nature Reviews Rheumatology

Volume: 5, P: 180
Preoperative markers for subsequent resection

Lisa Richards
Research Highlights01 May 2010
Nature Reviews Clinical Oncology

Volume: 7, P: 241
Sorafenib for Asian-Pacific HCC

Lisa Richards
Research Highlights01 Apr 2009
Nature Reviews Clinical Oncology

Volume: 6, P: 186

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