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Showing 1–17 of 17 results
Advanced filters: Author: Lora V Hooper Clear advanced filters

  • The mammalian intestine is colonized by complex indigenous bacterial communities that establish beneficial symbiotic relationships with their host, making important contributions to host metabolism and digestive efficiency. In this Opinion article, Lora Hooper explores the roles of immune suppression, evasion and subversion in the establishment of these important symbiotic relationships.

    • Lora V. Hooper
    Reviews
    Nature Reviews Microbiology
    Volume: 7, P: 367-374

  • The epithelial cells that line the intestine have been found to sense tight attachment of bacteria, and to respond by producing proteins that shape the effector functions of the immune system's TH17 cells.

    • Shai Bel
    • Lora V. Hooper
    News & Views
    Nature
    Volume: 526, P: 328-330

  • The microorganisms that colonize pregnant mice have been shown to prime the innate immune system in newborn offspring, preparing them for life in association with microbes.

    • Mihir Pendse
    • Lora V. Hooper
    News & Views
    Nature
    Volume: 533, P: 42-43

  • Quantitative metagenomics reveals an altered bacteriophage community in a mouse model of colitis, which overlaps with that observed in humans with inflammatory bowel disease (IBD), providing a tool for interrogating phage dynamics in IBD.

    • Breck A. Duerkop
    • Manuel Kleiner
    • Lora V. Hooper
    Research
    Nature Microbiology
    Volume: 3, P: 1023-1031

  • Although the vast numbers of commensal organisms that reside in the human gut are essential for health, they pose a continuous threat of invasion. The intestinal immune system has evolved unique immunological adaptations that help to maintain intestinal homeostasis.

    • Lora V. Hooper
    • Andrew J. Macpherson
    Reviews
    Nature Reviews Immunology
    Volume: 10, P: 159-169

  • Secreted C-type lectins protect the intestinal epithelium from Gram-positive bacteria; this study shows that for the C-type lectin RegIIIα, bacterial killing occurs in a two-step process whereby the lectin first binds to bacterial peptidoglycans then oligomerizes on the bacterial membrane to form a permeabilizing pore.

    • Sohini Mukherjee
    • Hui Zheng
    • Lora V. Hooper
    Research
    Nature
    Volume: 505, P: 103-107

  • IL-17 secreting Th17 cells have established roles in numerous immune-pathologies but paradoxically are required homeostatically in the maintenance of the intestinal barrier. Here the authors establish Raftlin-1 in the recruitment of phospholipids that are linked to the emergence of pathogenic Th17 cells in animal models of bowel inflammation.

    • Amir Kumar Singh
    • Ritesh Kumar
    • K. Venuprasad
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Gallo and his colleagues report that commensal bacteria on the skin help to dampen inflammation caused by skin injury in mice. They show that, after wounding, necrotic cells release RNA that triggers TLR3 on keratinocytes, causing inflammatory cytokine release. Commensal bacteria in the skin suppress this inflammatory response through triggering TLR2 on the keratinocytes.

    • Yuping Lai
    • Anna Di Nardo
    • Richard L Gallo
    Research
    Nature Medicine
    Volume: 15, P: 1377-1382

  • This Review looks at the regulation and functions of antimicrobial proteins in protecting epithelial surfaces from pathogen invasion and maintaining homeostasis with commensal microorganisms.

    • Richard L. Gallo
    • Lora V. Hooper
    Reviews
    Nature Reviews Immunology
    Volume: 12, P: 503-516

  • Tungstate inhibits molybdenum-cofactor-dependent microbial respiratory pathways and shows potential as a selective treatment for microbial imbalances that occur during inflammation of the gastrointestinal tract.

    • Wenhan Zhu
    • Maria G. Winter
    • Sebastian E. Winter
    Research
    Nature
    Volume: 553, P: 208-211