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Showing 1–2 of 2 results
Advanced filters: Author: Lorenz Bankel Clear advanced filters

  • Despite their differences, the rarer sarcoma CIC::DUX4 sarcoma (CDS) is typically treated with therapies developed for Ewing Sarcoma (EwS) with limited success. Here, the authors develop a co-clinical drug response profiling platform to establish patient-derived CDS and EwS tumoroids, identifying MCL1 inhibition as a promising therapeutic approach in CDS.

    • Willemijn Breunis
    • Eva Brack
    • Marco Wachtel
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Personalized treatment for cancer patients relies on the deep characterization of tumor cells from patient biopsies. In this study, functional multi-omics profiling of a pan-cancer cohort of malignant serous effusions (MSE) finds strong coherence between MSE and matched solid tumors, underlining the feasibility and utility of multi-modal MSE-based precision oncology.

    • Rebekka Wegmann
    • Lorenz Bankel
    • Berend Snijder
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21