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Direct prediction of intrinsically disordered protein conformational properties from sequence

ALBATROSS is a deep-learning-based model for predicting ensemble properties of intrinsically disordered proteins and protein regions, such as radius of gyration, end-to-end distance, polymer-scaling exponent and ensemble asphericity, directly from sequences.

Jeffrey M. Lotthammer
Garrett M. Ginell
Alex S. Holehouse
ResearchOpen Access31 Jan 2024
Nature Methods

Volume: 21, P: 465-476
Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins

Cliff Luke et al. report that lysoptosis is a eukaryotic stand-alone regulated cell death pathway. They identify that this new cell death modality predominates in the absence of neutralizing endogenous inhibitors.

Cliff J. Luke
Stephanie Markovina
Gary A. Silverman
ResearchOpen Access12 Jan 2022
Communications Biology

Volume: 5, P: 1-25
Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

Matthew Meyerson, Ramaswamy Govindan and colleagues examine the exome sequences and copy number profiles of 660 lung adenocarcinoma and 484 lung squamous cell carcinoma tumors. They identify novel significantly mutated genes and amplification peaks and find that around half of the tumors have at least five predicted neoepitopes.

Joshua D Campbell
Anton Alexandrov
Matthew Meyerson
Research09 May 2016
Nature Genetics

Volume: 48, P: 607-616
Loss of function mutation in Ank causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral disc

Takashi Ohnishi
Victoria Tran
Makarand V. Risbud
ResearchOpen Access19 Jul 2023
Cell Death & Disease

Volume: 14, P: 1-16
Tumour maintenance is mediated by eNOS

Endothelial nitric oxide synthase (eNOS) is shown to have a role in cellular transformation and tumour maintenance downstream of Ras–AKT signalling. eNOS exerts its effect through nitrosylation and activation of endogenous wild-type Ras proteins.

Kian-Huat Lim
Brooke B. Ancrile
Christopher M. Counter
Research16 Mar 2008
Nature

Volume: 452, P: 646-649
CD36 cell surface expression as a surrogate marker to identify ABL/JAK-class kinase fusions in pediatric BCP-ALL

Marion Strullu
Aurélie Caye-Eude
Elodie Lainey
Research17 Oct 2024
Leukemia

Volume: 39, P: 64-74
A gene–environment-induced epigenetic program initiates tumorigenesis

In mouse models of pancreatic cancer, a cooperative interaction between tissue damage and Kras gene mutation rapidly induces cancer-associated chromatin states in pre-malignant tissue, leading to gene dysregulation and neoplastic transformation.

Direna Alonso-Curbelo
Yu-Jui Ho
Scott W. Lowe
Research03 Feb 2021
Nature

Volume: 590, P: 642-648
Comparative genomics: genome-wide analysis in metazoan eukaryotes

Abel Ureta-Vidal
Laurence Ettwiller
Ewan Birney
Reviews01 Apr 2003
Nature Reviews Genetics

Volume: 4, P: 251-262
Visualizing genomes: techniques and challenges

Cydney B Nielsen
Michael Cantor
Ting Wang
Reviews25 Feb 2010
Nature Methods

Volume: 7, P: S5-S15
Feasibility of transcutaneous spinal direct current stimulation combined with locomotor training after spinal cord injury

Kelly A. Hawkins
Louis A. DeMark
Emily J. Fox
Research27 Apr 2022
Spinal Cord

Volume: 60, P: 971-977

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Direct prediction of intrinsically disordered protein conformational properties from sequence

Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins

Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

Loss of function mutation in Ank causes aberrant mineralization and acquisition of osteoblast-like-phenotype by the cells of the intervertebral disc

Tumour maintenance is mediated by eNOS

CD36 cell surface expression as a surrogate marker to identify ABL/JAK-class kinase fusions in pediatric BCP-ALL

A gene–environment-induced epigenetic program initiates tumorigenesis

Comparative genomics: genome-wide analysis in metazoan eukaryotes

Visualizing genomes: techniques and challenges

Feasibility of transcutaneous spinal direct current stimulation combined with locomotor training after spinal cord injury

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