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Nature Reviews Drug Discovery (3)
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Showing 1–4 of 4 results

Advanced filters: Author: Louisa Temme Clear advanced filters

Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy

This study describes structures of the transcription factor brachyury revealing the mechanism of DNA recognition. They identify fragments using X-ray fragment screening and optimize these into potent ligands with potential as cancer therapeutics.

Joseph A. Newman
Angeline E. Gavard
David H. Drewry
ResearchOpen Access14 Feb 2025
Nature Communications

Volume: 16, P: 1-14
PKN3: a target in cancer metastasis

Louisa Temme
Tuomo Laitinen
Christopher R. M. Asquith
News14 Sept 2022
Nature Reviews Drug Discovery

Volume: 21, P: 704
eEF2K: an atypical kinase target for cancer

Louisa Temme
Christopher R. M. Asquith
News13 Jul 2021
Nature Reviews Drug Discovery

Volume: 20, P: 577
STK19: a new target for NRAS-driven cancer

Christopher R. M. Asquith
Louisa Temme
News25 Jun 2020
Nature Reviews Drug Discovery

Volume: 19, P: 579