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Showing 1–50 of 68 results

Advanced filters: Author: Luca Romeo Clear advanced filters

Reducibility of higher-order networks from dynamics

The topology of interactions is shaping dynamics of complex systems. Here, the authors develop a quantitative method to determine how much higher-order structure can be reduced without affecting dynamical behavior, revealing when higher-order interactions matter.

Maxime Lucas
Luca Gallo
Manlio De Domenico
ResearchOpen Access15 Jan 2026
Nature Communications

Volume: 17, P: 1-16
Autofluorescence and Fourier transform infrared analyses trace dietary fluorophores and reveal plastic contamination in the gut of mosquito larvae

Sara Soldano
Maduka L. Weththimuni
Francesca Scolari
ResearchOpen Access09 Feb 2026
Scientific Reports

P: 1-15
Measuring the semantic priming effect across many languages

In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

Erin M. Buchanan
Kelly Cuccolo
Savannah C. Lewis
Research24 Sept 2025
Nature Human Behaviour

Volume: 10, P: 182-201
PSD3 downregulation confers protection against fatty liver disease

Employing a candidate gene approach, Mancina et al. identify a genetic variant of the Pleckstrin and Sec7 domain-containing 3 (PSD3) gene that reduces susceptibility to fatty liver disease. Functional studies in vitro and in vivo demonstrate that targeting PSD3 protects against fatty liver disease.

Rosellina M. Mancina
Kavitha Sasidharan
Stefano Romeo
ResearchOpen Access31 Jan 2022
Nature Metabolism

Volume: 4, P: 60-75
Targeted antisense oligonucleotide treatment rescues developmental alterations in spinal muscular atrophy organoids

Spinal cord organoids from SMA patients reveal widespread neurodevelopmental defects. Single-cell and functional analyses show global dysregulation, which can be rescued by SMN-increasing therapy, stressing the importance of timely intervention.

Irene Faravelli
Paola Rinchetti
Stefania Corti
ResearchOpen Access21 Dec 2025
Nature Communications

Volume: 17, P: 1-20
A transgenic mouse model for the detection of cellular stress induced by toxic inorganic compounds

Maria Grazia Sacco
Luigi Zecca
Paolo Vezzoni
Research01 Dec 1997
Nature Biotechnology

Volume: 15, P: 1392-1397
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease

The application of partitioned polygenic scores to data from cohorts of patients identifies two distinct subtypes of MASLD with different cardiometabolic risk profiles.

Oveis Jamialahmadi
Antonio De Vincentis
Stefano Romeo
ResearchOpen Access09 Dec 2024
Nature Medicine

Volume: 30, P: 3614-3623
Increased ectodysplasin-A2-receptor EDA2R is a ubiquitous hallmark of aging and mediates parainflammatory responses

In a broad cross-tissue analysis, the authors show that a receptor called EDA2R steadily increases with age in both humans and animal models, and becomes even more active in conditions like obesity and diabetes, intensifying inflammation-like processes in muscle cells.

Maria Chiara Barbera
Luca Guarrera
Marco Bolis
ResearchOpen Access23 Feb 2025
Nature Communications

Volume: 16, P: 1-11
Chromatin remodeling restrains oncogenic functions in prostate cancer

Prostate cancer (PCa) evaluation remains challenging due to its heterogenous and multifocal nature. Here, the authors reconstruct the nuclear chromatin compartmentalization of PCa patients-derived biopsies distinguishing two epigenetic subtypes and deriving an 18-gene signature with prognostic value on TCGA samples that is further validated with multiple independent PCa cohorts.

Valentina Rosti
Giovanni Lembo
Chiara Lanzuolo
ResearchOpen Access16 Oct 2025
Nature Communications

Volume: 16, P: 1-20
Figurative Archive: an open dataset and web-based application for the study of metaphor

Maddalena Bressler
Veronica Mangiaterra
Valentina Bambini
ResearchOpen Access07 Jan 2026
Scientific Data

Volume: 13, P: 1-16
Human genetics of steatotic liver disease: insights into insulin resistance and lipid metabolism

This Review summarizes our current knowledge about the genetic underpinnings of metabolic-dysfunction-associated steatotic liver disease and highlights its causal association with type 2 diabetes and insulin resistance.

Rosellina M. Mancina
Luca Valenti
Stefano Romeo
Reviews17 Oct 2025
Nature Metabolism

Volume: 7, P: 2199-2211
Machine learning analyses of antibody somatic mutations predict immunoglobulin light chain toxicity

Systemic light chain amyloidosis (AL) is caused by the production of toxic light chains and can be fatal, yet effective treatments are often not possible due to delayed diagnosis. Here the authors show that a machine learning platform analyzing light chain somatic mutations allows the prediction of light chain toxicity to serve as a possible tool for early diagnosis of AL.

Maura Garofalo
Luca Piccoli
Andrea Cavalli
ResearchOpen Access10 Jun 2021
Nature Communications

Volume: 12, P: 1-10
Publisher Correction: Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease

Oveis Jamialahmadi
Antonio De Vincentis
Stefano Romeo
Amendments and CorrectionsOpen Access16 Jan 2025
Nature Medicine

Volume: 31, P: 700
Incidence, determinants and prognostic relevance of dyspnea at admission in patients with Takotsubo syndrome: results from the international multicenter GEIST registry

Luca Arcari
Maria Beatrice Musumeci
Francesco Santoro
ResearchOpen Access12 Aug 2020
Scientific Reports

Volume: 10, P: 1-8
Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women

Analysis using a combination of molecular and genetic epidemiological approaches reveals an interaction between female sex and the genetic variant PNPLA3 p.I148M that might explain why some women have increased susceptibility to fatty liver disease after onset of menopause.

Alessandro Cherubini
Mahnoosh Ostadreza
Luca Valenti
ResearchOpen Access25 Sept 2023
Nature Medicine

Volume: 29, P: 2643-2655
Assessment of circulating tumor DNA in patients with locally advanced rectal cancer treated with neoadjuvant therapy

Chiara Molinari
Giorgia Marisi
Alessandro Passardi
ResearchOpen Access28 Nov 2024
Scientific Reports

Volume: 14, P: 1-9
Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma

Lipid accumulation in the liver leads to nonalcoholic fatty liver disease (NAFLD) that is a risk factor for developing hepatocellular carcinoma (HCC). Here, the authors show that activation of the translation initiation factor eIF6 promotes lipid accumulation in the liver and targeting eIF6 in murine models reduces NAFLD and associated HCC.

Alessandra Scagliola
Annarita Miluzio
Stefano Biffo
ResearchOpen Access12 Aug 2021
Nature Communications

Volume: 12, P: 1-16
Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination

Here the authors use three different mouse models to show that prior infection or mRNA vaccination can protect against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) independently of antibodies, highlighting the importance of T cell-derived interferon-γ (IFN-γ) in host defense and the need to consider this measure of protection in vaccination.

Valeria Fumagalli
Micol Ravà
Matteo Iannacone
ResearchOpen Access14 Mar 2024
Nature Immunology

Volume: 25, P: 633-643
Author Correction: Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women

Alessandro Cherubini
Mahnoosh Ostadreza
Luca Valenti
Amendments and CorrectionsOpen Access24 Jan 2024
Nature Medicine

Volume: 30, P: 1212
Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ

The role of epigenetic deregulation in colorectal cancer (CRC) is not fully understood yet. Here the authors use patient-derived organoids, epigenomics and single-cell RNA-seq to reveal that YAP/TAZ are key regulators that bind to active enhancers in CRC and promote tumour survival.

Giulia Della Chiara
Federica Gervasoni
Massimiliano Pagani
ResearchOpen Access20 Apr 2021
Nature Communications

Volume: 12, P: 1-18
Red blood cell metabolomics identify ergothioneine as a key metabolite in DMARD-naïve rheumatoid arthritis and response to methotrexate

Johanna Sigaux
Christophe Junot
Luca Semerano
ResearchOpen Access09 Sept 2024
Scientific Reports

Volume: 14, P: 1-7
Footprint of sustained poleward warm water flow within East Antarctic submarine canyons

Sediment drifts record long-lasting southward flowing currents within submarine canyons, which convey warm Circumpolar Deep Water toward the East Antarctic shelf break, thus facilitating warm water intrusion on the continental shelf.

Federica Donda
Michele Rebesco
Roberto Romeo
ResearchOpen Access17 Jul 2024
Nature Communications

Volume: 15, P: 1-10
MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals

Benedetta Donati
Paola Dongiovanni
Luca Valenti
ResearchOpen Access03 Jul 2017
Scientific Reports

Volume: 7, P: 1-10
Glucocorticoid receptor antagonization propels endogenous cardiomyocyte proliferation and cardiac regeneration

Pianca and Sacchi et al. unveil an important role for glucocorticoids and their receptor (GR) in cardiomyocyte cytoarchitectural/metabolic maturation, cell cycle exit and loss of regenerative ability, and they propose GR antagonization as a strategy for heart regeneration.

Nicola Pianca
Francesca Sacchi
Gabriele D’Uva
Research23 Jun 2022
Nature Cardiovascular Research

Volume: 1, P: 617-633
Drugging the lncRNA MALAT1 via LNA gapmeR ASO inhibits gene expression of proteasome subunits and triggers anti-multiple myeloma activity

Nicola Amodio
Maria Angelica Stamato
Pierfrancesco Tassone
ResearchOpen Access22 Feb 2018
Leukemia

Volume: 32, P: 1948-1957
A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity

The Myc transcription factor is a major regulator of stem cell (SC) self-renewal and pluripotency but how this integrates signals from other pathways is unclear. Here, the authors show that Myc activation triggers epigenetic memory in self renewing embryonic SCs via PRC2-mediated potentiation of the Wnt pathway.

Luca Fagnocchi
Alessandro Cherubini
Alessio Zippo
ResearchOpen Access15 Jun 2016
Nature Communications

Volume: 7, P: 1-17
Is there ethnic discrimination in Roma children’s access to sports clubs in Hungary? Evidence from field experiments in basketball, volleyball, and soccer

Borbála Takács
Luca Váradi
Borbála Simonovits
ResearchOpen Access16 Oct 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-14
Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases

Coupling microbial metagenomics with machine learning enables prediction of donor strain engraftment after fecal microbiota transplantation (FMT) for a range of diseases, and may help tailor design of FMT to optimize microbial engraftment and achieve clinical outcomes.

Gianluca Ianiro
Michal Punčochář
Nicola Segata
ResearchOpen Access15 Sept 2022
Nature Medicine

Volume: 28, P: 1913-1923
IMMUNOREACT 9 metachronous rectal cancers have high HLA-ABC expression on healthy epithelium but a lower infiltration of CD3+ T cells than primary lesions

Beatrice Salmaso
Melania Scarpa
Marco Scarpa
ResearchOpen Access30 Nov 2024
Scientific Reports

Volume: 14, P: 1-11
MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state

Breast cancer tumors originating from mammary luminal epithelial cells are highly heterogeneous. Here, the authors show MYC-driven tumor initiation is reliant on cell reprogramming via an epigenetic program which leads to mammary luminal epithelial cells acquiring basal/stem cell-like properties.

Vittoria Poli
Luca Fagnocchi
Alessio Zippo
ResearchOpen Access09 Mar 2018
Nature Communications

Volume: 9, P: 1-16
MLL4-associated condensates counterbalance Polycomb-mediated nuclear mechanical stress in Kabuki syndrome

MLL4 (KMT2D) loss of function, as found in Kabuki syndrome, affects the chromatin compartmentalization of Polycomb proteins and changes the nuclear architecture. Inhibition of ATR reestablishes mechanosignaling of mutant mesenchymal stem cells and their commitment to becoming chondrocytes.

Alessandra Fasciani
Sarah D’Annunzio
Alessio Zippo
Research09 Nov 2020
Nature Genetics

Volume: 52, P: 1397-1411
Frataxin gene editing rescues Friedreich’s ataxia pathology in dorsal root ganglia organoid-derived sensory neurons

Friedreich’s ataxia (FRDA) is an autosomal-recessive disorder. Here the authors describe a DRG organoid from patient derived-neurons and co-culture with muscle cells to mimic the disorder in vitro and demonstrate potential correction of the phenotype by CRISPR based editing.

Pietro Giuseppe Mazzara
Sharon Muggeo
Vania Broccoli
ResearchOpen Access21 Aug 2020
Nature Communications

Volume: 11, P: 1-18
Author Correction: MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state

Vittoria Poli
Luca Fagnocchi
Alessio Zippo
Amendments and CorrectionsOpen Access20 Sept 2018
Nature Communications

Volume: 9, P: 1
Rare Pathogenic Variants Predispose to Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease

Serena Pelusi
Guido Baselli
Luca Vittorio Carlo Valenti
ResearchOpen Access06 Mar 2019
Scientific Reports

Volume: 9, P: 1-10
Robust anticipation of continuous steering actions from electroencephalographic data during simulated driving

Giovanni M. Di Liberto
Michele Barsotti
Luca Ascari
ResearchOpen Access03 Dec 2021
Scientific Reports

Volume: 11, P: 1-10
Sensing with tools extends somatosensory processing beyond the body

Tools are embodied by the human somatosensory system, serving as sensory extensions of the human body.

Luke E. Miller
Luca Montroni
Alessandro Farnè
Research12 Sept 2018
Nature

Volume: 561, P: 239-242
Metabolic and genetic determinants for progression to severe liver disease in subjects with obesity from the UK Biobank

Antonio De Vincentis
Federica Tavaglione
Umberto Vespasiani-Gentilucci
Research08 Nov 2021
International Journal of Obesity

Volume: 46, P: 486-493
The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids

Sebastian Prill
Andrea Caddeo
Stefano Romeo
ResearchOpen Access12 Aug 2019
Scientific Reports

Volume: 9, P: 1-12
GIS-based integration of marine data for assessment and management of a highly anthropized coastal area

Luciano Bosso
Simona Saviano
Domenico D’Alelio
ResearchOpen Access09 May 2025
Scientific Reports

Volume: 15, P: 1-18
Characterization of subcutaneous and omental adipose tissue in patients with obesity and with different degrees of glucose impairment

Anna Belligoli
Chiara Compagnin
Roberto Vettor
ResearchOpen Access05 Aug 2019
Scientific Reports

Volume: 9, P: 1-12
Weak linkage at 4p16 to predisposition for human neuroblastoma

Patrizia Perri
Luca Longo
Gian Paolo Tonini
Research25 Nov 2002
Oncogene

Volume: 21, P: 8356-8360
CK2 modulates adipocyte insulin-signaling and is up-regulated in human obesity

Christian Borgo
Gabriella Milan
Roberto Vettor
ResearchOpen Access14 Dec 2017
Scientific Reports

Volume: 7, P: 1-15
Nature-based interventions for individuals with rare skeletal disorders: evaluation of a 5-day sailing program on health-related quality of life

Manila Boarini
Andrea Romeo
Luca Sangiorgi
ResearchOpen Access01 Nov 2024
Scientific Reports

Volume: 14, P: 1-13
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome

Judith Bovée and colleagues report the identification of somatic mosaic mutations in IDH1 and IDH2 in tumors from individuals with Ollier disease and Maffucci syndrome, which are non-hereditary skeletal disorders characterized by multiple enchondromas.

Twinkal C Pansuriya
Ronald van Eijk
Judith V M G Bovée
Research06 Nov 2011
Nature Genetics

Volume: 43, P: 1256-1261
Long-COVID autonomic syndrome in working age and work ability impairment

Luca Rinaldi
Stefano Rigo
Franca Barbic
ResearchOpen Access23 May 2024
Scientific Reports

Volume: 14, P: 1-12
Bright light exposure reduces TH-positive dopamine neurons: implications of light pollution in Parkinson's disease epidemiology

Stefania Romeo
Cristina Viaggi
Roberto Maggio
ResearchOpen Access06 Mar 2013
Scientific Reports

Volume: 3, P: 1-9
Serological follow-up of SARS-CoV-2 asymptomatic subjects

Gregorio Paolo Milani
Laura Dioni
Giuliano Zanchetta
ResearchOpen Access18 Nov 2020
Scientific Reports

Volume: 10, P: 1-7
Consanguineous marriages, pearls and perils: Geneva International Consanguinity Workshop Report

Hanan Hamamy
Stylianos E Antonarakis
Alan H Bittles
Research06 May 2011
Genetics in Medicine

Volume: 13, P: 841-847
Effectiveness and safety of XEN45 implant over 12 months of follow-up: data from the XEN-Glaucoma Treatment Registry

Francesco Oddone
Gloria Roberti
Michele Figus
ResearchOpen Access06 Jul 2023
Eye

Volume: 38, P: 103-111
Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

Piccolo and colleagues report that the YAP/TAZ factors form ternary complexes with TEAD and AP-1 factors to drive a transcriptional program that promotes cell proliferation and tumour growth.

Francesca Zanconato
Mattia Forcato
Stefano Piccolo
Research10 Aug 2015
Nature Cell Biology

Volume: 17, P: 1218-1227

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