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Comprehensive analysis of Enterobacteriaceae IncX plasmids reveals robust conjugation regulators PrfaH, H-NS, and conjugation-fitness tradeoff

A detailed analysis of IncX plasmids identifies PrfaH as crucial for conjugation and H-NS as a regulator of the balance between conjugation and host fitness, highlighting PrfaH as a potential target for combating antimicrobial resistance.

Jun Yang
Yaoyao Lu
Jian-Hua Liu
ResearchOpen Access04 Mar 2025
Communications Biology

Volume: 8, P: 1-17

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Comprehensive analysis of Enterobacteriaceae IncX plasmids reveals robust conjugation regulators PrfaH, H-NS, and conjugation-fitness tradeoff

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