DNA ligase I (LIG1), an essential enzyme implicated in DNA recombination and DNA repair, is modulated by the oncoprotein SRSF1. In non-small cell lung cancer (NSCLC) cells, LIG1 inhibition is associated with reduced proliferation and increased apoptosis. LIG1 expression is therefore a poor prognosis factor in NSCLC.
- Elena Martínez-Terroba
- Teresa Ezponda
- María J. Pajares
