Ferroptosis and pyroptosis are emerging regulated forms of cell death promising for cancer therapy. Here this group reports fabricating folic acid and croconaine functionalized upconversion nanoparticles for mobilizing intracellular stores of endogenous iron, and spatiotemporally controlling lysosome-intrinsic Fenton chemistry, thereby triggering lysosomal membrane permeabilization-associated ferroptosis and pyroptosis dual-induction.
- Luwen Zhu
- Jiahao Hu
- Liming Wu
