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Oncogene (12)
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Showing 1–41 of 41 results

Advanced filters: Author: M Dobbelstein Clear advanced filters

Constitutive expression of the transcriptional co-activator IκBζ promotes melanoma growth and immunotherapy resistance

IκBζ is a rather unknown transcriptional co-factor of NF-κB. Here, the authors show that constitutive IκBζ expression in a subgroup of patients with melanoma drives immunotherapy resistance and enhanced tumor growth.

Antonia Kolb
Ana-Marija Kulis-Mandic
Daniela Kramer
ResearchOpen Access25 Jun 2025
Nature Communications

Volume: 16, P: 1-19
Definition of a major p53 binding site on Ad2E1B58K protein and a possible nuclear localization signal on the Ad12E1B54K protein

Roger JA Grand
Julian Parkhill
Phillip H Gallimore
Research08 Feb 1999
Oncogene

Volume: 18, P: 955-965
Infection with E1B-mutant adenovirus stabilizes p53 but blocks p53 acetylation and activity through E1A

I Savelyeva
M Dobbelstein
Research11 Oct 2010
Oncogene

Volume: 30, P: 865-875
A sequence element of p53 that determines its susceptibility to viral oncoprotein-targeted degradation

Jijie Gu
Rachel M Rubin
Zhi-Min Yuan
Research27 Jun 2001
Oncogene

Volume: 20, P: 3519-3527
Chromothripsis followed by circular recombination drives oncogene amplification in human cancer

Seismic amplifications arise from several cycles of circular recombination of circular extrachromosomal DNA formed as a result of chromothripsis. The process provides a mechanism for oncogene amplification in a number of different human tumor types.

Carolina Rosswog
Christoph Bartenhagen
Matthias Fischer
Research15 Nov 2021
Nature Genetics

Volume: 53, P: 1673-1685
p53-Based cyclotherapy: exploiting the ‘guardian of the genome’ to protect normal cells from cytotoxic therapy

B Rao
S Lain
A M Thompson
ReviewsOpen Access14 Nov 2013
British Journal of Cancer

Volume: 109, P: 2954-2958
Effect of an hdm-2 antagonist peptide inhibitor on cell cycle progression in p53-deficient H1299 human lung carcinoma cells

A VanderBorght
A Valckx
J Arts
Research29 May 2006
Oncogene

Volume: 25, P: 6672-6677
Correction: Corrigendum: Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment

E. M. Alexandrova
A. R. Yallowitz
U. M. Moll
Amendments and Corrections30 Sept 2015
Nature

Volume: 527, P: 398
Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design

Here the authors demonstrate that the SARS-CoV-2 main protease (Mpro) is subject to redox regulation in vitro, reversibly switching between the enzymatically active dimer and the functionally dormant monomer through redox modifications of cysteine residues.

Lisa-Marie Funk
Gereon Poschmann
Kai Tittmann
ResearchOpen Access09 Jan 2024
Nature Communications

Volume: 15, P: 1-18
Transcriptional dysregulation of the p73L / p63 / p51 / p40 / KET gene in human squamous cell carcinomas: expression of Δ Np73L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51

M Senoo
I Tsuchiya
S Habu
ResearchOpen Access01 May 2001
British Journal of Cancer

Volume: 84, P: 1235-1241
Viral-mediated stabilization of AU-rich element containing mRNA contributes to cell transformation

T Kuroshima
M Aoyagi
F Higashino
Research14 Feb 2011
Oncogene

Volume: 30, P: 2912-2920
Regulation and activation of p53 and its family members

M A E Lohrum
KH Vousden
Reviews13 Nov 1999
Cell Death & Differentiation

Volume: 6, P: 1162-1168
Structure, function and regulation of p63 and p73

M Levrero
V De Laurenzi
J Y J Wang
Reviews13 Nov 1999
Cell Death & Differentiation

Volume: 6, P: 1146-1153
Interaction of viral proteins with host cell death machinery

David J Granville
Chris M Carthy
Bruce M McManus
Reviews03 Aug 1998
Cell Death & Differentiation

Volume: 5, P: 653-659
HuR is exported to the cytoplasm in oral cancer cells in a different manner from that of normal cells

H Hasegawa
W Kakuguchi
F Higashino
ResearchOpen Access09 Jun 2009
British Journal of Cancer

Volume: 100, P: 1943-1948
Self-association of adenovirus type 5 E1B-55 kDa as well as p53 is essential for their mutual interaction

M Morawska-Onyszczuk
K Bieńkowska-Szewczyk
M Dobbelstein
Research21 Dec 2009
Oncogene

Volume: 29, P: 1773-1786
Functions of TAp63 and p53 in restraining the development of metastatic cancer

E H Tan
J P Morton
P A J Muller
Research22 Jul 2013
Oncogene

Volume: 33, P: 3325-3333
Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment

Novel hotspot mutant p53 gain-of-function mouse model shows that tumours depend on its sustained expression, and genetic and pharmacological approaches reveal mutant p53 as an actionable cancer drug target.

E. M. Alexandrova
A. R. Yallowitz
U. M. Moll
Research25 May 2015
Nature

Volume: 523, P: 352-356
Recruitment of the tumour suppressor protein p73 by Kaposi’s Sarcoma Herpesvirus latent nuclear antigen contributes to the survival of primary effusion lymphoma cells

S Santag
W Jäger
T F Schulz
Research10 Sept 2012
Oncogene

Volume: 32, P: 3676-3685
HuR keeps an angiogenic switch on by stabilising mRNA of VEGF and COX-2 in tumour endothelium

T Kurosu
N Ohga
K Hida
ResearchOpen Access01 Feb 2011
British Journal of Cancer

Volume: 104, P: 819-829
JNK–NQO1 axis drives TAp73-mediated tumor suppression upon oxidative and proteasomal stress

A Kostecka
A Sznarkowska
J Zawacka-Pankau
ResearchOpen Access23 Oct 2014
Cell Death & Disease

Volume: 5, P: e1484
p53 promotes adenoviral replication and increases late viral gene expression

J A Royds
M Hibma
A W Braithwaite
Research24 Oct 2005
Oncogene

Volume: 25, P: 1509-1520
Mdm4 supports DNA replication in a p53-independent fashion

Kai Wohlberedt
Ina Klusmann
Matthias Dobbelstein
Research19 May 2020
Oncogene

Volume: 39, P: 4828-4843
p63 and p73 in human cancer: defining the network

M P DeYoung
L W Ellisen
Reviews05 Mar 2007
Oncogene

Volume: 26, P: 5169-5183
Correction: Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells

Daniela Kramer
Nadine Stark
Matthias Dobbelstein
Amendments and Corrections03 Sept 2018
Cell Death & Differentiation

Volume: 26, P: 780
Decreased PRC2 activity supports the survival of basal-like breast cancer cells to cytotoxic treatments

Iga K. Mieczkowska
Garyfallia Pantelaiou-Prokaki
Florian Wegwitz
ResearchOpen Access29 Nov 2021
Cell Death & Disease

Volume: 12, P: 1-13
Proteomic peptide profiling for preemptive diagnosis of acute graft-versus-host disease after allogeneic stem cell transplantation

E M Weissinger
J Metzger
A Ganser
ResearchOpen Access11 Jul 2013
Leukemia

Volume: 28, P: 842-852
Anthracyclines induce the accumulation of mutant p53 through E2F1-dependent and -independent mechanisms

M Bug
M Dobbelstein
Research28 Mar 2011
Oncogene

Volume: 30, P: 3612-3624
HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer

R Schulz
F Streller
U M Moll
ResearchOpen Access02 Jan 2014
Cell Death & Disease

Volume: 5, P: e980
A pro-apoptotic function of iASPP by stabilizing p300 and CBP through inhibition of BRMS1 E3 ubiquitin ligase activity

D Kramer
M Schön
M Dobbelstein
ResearchOpen Access12 Feb 2015
Cell Death & Disease

Volume: 6, P: e1634
Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells

Daniela Kramer
Nadine Stark
Matthias Dobbelstein
Research11 Nov 2016
Cell Death & Differentiation

Volume: 24, P: 300-316
A novel t(3;13)(q13;q12) translocation fusing FLT3 with GOLGB1: toward myeloid/lymphoid neoplasms with eosinophilia and rearrangement of FLT3?

E Troadec
S Dobbelstein
N Gachard
CorrespondenceOpen Access31 Oct 2016
Leukemia

Volume: 31, P: 514-517
p73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis

F Talos
A Abraham
U M Moll
Research15 Nov 2010
Cell Death & Differentiation

Volume: 17, P: 1816-1829
UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib

H Landmann
D A Proia
M Dobbelstein
ResearchOpen Access11 Sept 2014
Cell Death & Disease

Volume: 5, P: e1411
The α/β carboxy-terminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 γ-like proteins

S Wolff
F Talos
U M Moll
Research20 Mar 2009
Cell Death & Differentiation

Volume: 16, P: 1108-1117
PAX5 mutations occur frequently in adult B-cell progenitor acute lymphoblastic leukemia and PAX5 haploinsufficiency is associated with BCR-ABL1 and TCF3-PBX1 fusion genes: a GRAALL study

J Familiades
M Bousquet
É Delabesse
Research09 Jul 2009
Leukemia

Volume: 23, P: 1989-1998
E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis

M Lizé
S Pilarski
M Dobbelstein
Research04 Dec 2009
Cell Death & Differentiation

Volume: 17, P: 452-458
Comprehensive identification of genes driven by ERV9-LTRs reveals TNFRSF10B as a re-activatable mediator of testicular cancer cell death

U Beyer
S K Krönung
M Dobbelstein
Research29 May 2015
Cell Death & Differentiation

Volume: 23, P: 64-75
Brdm2—an aberrant hypomorphic p63 allele

F Talos
S Wolff
U M Moll
Correspondence30 Oct 2009
Cell Death & Differentiation

Volume: 17, P: 184-186
Identification of GSX2 and AF10 as NUP98 partner genes in myeloid malignancies

G Soler
S Kaltenbach
S P Romana
CorrespondenceOpen Access12 Jul 2013
Blood Cancer Journal

Volume: 3, P: e124
Synergy between expression of fusogenic membrane proteins, chemotherapy and facultative virotherapy in colorectal cancer

D Hoffmann
J-M Bangen
O Wildner
Research22 Jun 2006
Gene Therapy

Volume: 13, P: 1534-1544