Nature Search

Neoadjuvant ipilimumab and nivolumab in resectable cutaneous squamous cell carcinoma: a randomized phase 2 trial

Results from the randomized, noncomparative, phase 2 MATISSE trial show that ultra-short neoadjuvant therapy with ipilimumab and nivolumab can prevent surgery and radiotherapy in patients with resectable cutaneous squamous cell carcinoma, with an early decrease in total lesion glycolysis by [¹⁸F]FDG-PET/CT associated with response.

Sabine E. Breukers
Joleen J. H. Traets
Charlotte L. Zuur

ResearchOpen Access08 Oct 2025

Nature Medicine

P: 1-10

5-Fluorouracil treatment induces characteristic T>G mutations in human cancer

5-Fluorouracil (5-FU) is a commonly used chemo drug to treat cancer patients. Using in vitro 5-FU treated organoids and in vivo 5-FU treated human cancer data, the authors describe a 5-FU mutational signature that is similar to COSMIC signature 17 frequently observed in untreated cancers

Sharon Christensen
Bastiaan Van der Roest
Arne Van Hoeck

ResearchOpen Access08 Oct 2019

Nature Communications

Volume: 10, P: 1-11

Reversal of Toxicity of 5-Fluorouracil and 5-Fluorodeoxyuridine for Candida Albicans by Pyridoxine and Pyridoxamine

M. L. LITTMAN
T. MIWATANI

Research23 Dec 1961

Nature

Volume: 192, P: 1155-1159

A ROS-mediated oxidation-O-GlcNAcylation cascade governs ferroptosis

Zhang, Ma et al. report that ROS-activated O-GlcNAc transferase promotes FOXK2 O-GlcNAcylation and nuclear translocation to upregulate SLC7A11 expression, thereby modulating ferroptosis sensitivity, tumour development and chemoradiotherapy efficacy.

Hemeng Zhang
Jialin Ma
Huadong Pei

Research18 Jul 2025

Nature Cell Biology

Volume: 27, P: 1288-1300

Naturally occurring viral R plasmid with a circular supercoiled genome in the extracellular state

J. M. PEMBERTON
W. T. TUCKER

Research01 Mar 1977

Nature

Volume: 266, P: 50-51

BH3 mimetics targeting BCL-XL have efficacy in solid tumors with RB1 loss and replication stress

While BH3-mimetics can be effective for treatment of haematological malignancies, their efficacy in solid tumours is limited. Here, using a range of patient-derived prostate cancer models, the authors demonstrate that increased replication stress induced by RB1 loss confers sensitivity to BH3 mimetics targeting BCL-XL.

Andreas Varkaris
Keshan Wang
Steven P. Balk

ResearchOpen Access28 May 2025

Nature Communications

Volume: 16, P: 1-17

ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97

VCP/p97 is identified as a co-factor to the fusion oncoprotein ASPSCR1::TFE3. They co-localize on chromatin, co-dependent for enhancer looping and transcriptional regulation in alveolar soft part sarcomas and Xp11- rearranged renal cell carcinomas.

Amir Pozner
Li Li
Kevin B. Jones

ResearchOpen Access07 Feb 2024

Nature Communications

Volume: 15, P: 1-21

U-rich elements drive pervasive cryptic splicing in 3’ UTR massively parallel reporter assays

Massively parallel reporter assays (MPRAs) are powerful technologies for measuring the impact of non-coding sequences on gene expression. Here, the authors demonstrate that MPRA reporters often undergo cryptic splicing that is activated by U-rich sequences, which can convolute MPRA measurements.

Khoa Dao
Courtney F. Jungers
Anthony M. Mustoe

ResearchOpen Access25 Jul 2025

Nature Communications

Volume: 16, P: 1-16

Natural short-lived halogens exert an indirect cooling effect on climate

Short-lived halogens have a substantial indirect cooling effect on climate and this cooling effect has increased since pre-industrial times owing to anthropogenic amplification of natural halogen emissions.

Alfonso Saiz-Lopez
Rafael P. Fernandez
Jean-François Lamarque

ResearchOpen Access28 Jun 2023

Nature

Volume: 618, P: 967-973

Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue

An optical detection and analysis platform quantifies aggregate density, distribution and size in fluorescently labelled post-mortem human brain tissue.

Rebecca Andrews
Bin Fu
Steven F. Lee

ResearchOpen Access01 Oct 2025

Nature Biomedical Engineering

P: 1-13

Non-canonical dihydrolipoyl transacetylase promotes chemotherapy resistance via mitochondrial tetrahydrofolate signaling

Chemotherapy is commonly used for the treatment of cancer but resistance often occurs. Here, the authors identify mitochondrial DLAT as driver of chemotherapy resistance via interaction with (MTHFD2) and develop a decoy peptide which blocks this interaction, restoring sensitivity to chemotherapy.

Jung Seok Hwang
JiHoon Kang
Sumin Kang

ResearchOpen Access08 Oct 2025

Nature Communications

Volume: 16, P: 1-18

Sea cucumber sulfated polysaccharides extract potentiates the anticancer effect of 5- fluorouracil on hepatocellular carcinoma cells

Samah E. Ismail
Neveen A. Hussein
Esmail M. El-Fakharany

ResearchOpen Access23 Jun 2025

Scientific Reports

Volume: 15, P: 1-15

SETBP1 variants outside the degron disrupt DNA-binding, transcription and neuronal differentiation capacity to cause a heterogeneous neurodevelopmental disorder

Different types of SETBP1 variants cause variable developmental syndromes with only partial clinical and functional overlaps. Here, the authors report that SETBP1 variants outside the degron region impair DNA-binding, transcription, and neuronal differentiation capacity and morphologies.

Maggie M. K. Wong
Rosalie A. Kampen
Simon E. Fisher

ResearchOpen Access10 Oct 2025

Nature Communications

Volume: 16, P: 1-23

Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation

Chemotherapy-induced death of colon cancer cells causes ATP release triggering P2X4 to mediate an mTOR-dependent pro-survival program in neighbouring cancer cells, which renders them sensitive to mTOR inhibition.

Mark Schmitt
Fatih Ceteci
Florian R. Greten

Research16 Nov 2022

Nature

Volume: 612, P: 347-353

Altered Enzymes in Ageing Human Fibroblasts

R. HOLLIDAY
G. M. TARRANT

Research07 Jul 1972

Nature

Volume: 238, P: 26-30

Rewiring glucose metabolism improves 5-FU efficacy in p53-deficient/KRAS^G12D glycolytic colorectal tumors

In p53-deficient colorectal cancer organoids, 5-fluorouracil induces pyrimidine imbalance, which causes DNA damage and cell death. Rewiring glucose metabolism through PDK inhibition by DCA enhances 5-FU toxicity in glycolytic p53-deficient organoids.

Marlies C. Ludikhuize
Sira Gevers
Maria J. Rodríguez Colman

ResearchOpen Access31 Oct 2022

Communications Biology

Volume: 5, P: 1-16

In vivo CRISPR screening in head and neck cancer reveals Uchl5 as an immunotherapy target

UCHL5 is a deubiquitinating enzyme that cleaves Lys-48-linked polyubiquitin chains. Here, the authors discover through in-vivo CRISPR-Cas9 screens that Uchl5 is involved in immune evasion and modulation of extracellular matrix deposition in head and neck squamous cell carcinoma.

Cong Fu
Robert Saddawi-Konefka
Robert T. Manguso

ResearchOpen Access29 Sept 2025

Nature Communications

Volume: 16, P: 1-18

Sustainability-based comparative stability of oxaliplatin plus leucovorin and 5-fluorouracil in infusion bags with application to plasma and colonic media samples

Hadir M. Maher
Salma Mahmoud Mohamed
Amira Fawzy El-Yazbi

ResearchOpen Access23 May 2025

Scientific Reports

Volume: 15, P: 1-19

Delayed leaf green-up is associated with fine particulate air pollution in China

PM_2.5 pollution partially counteracts vegetation greening trends by delaying green-up dates and reducing photosynthetic activity. This study shows that the negative feedback between PM_2.5 pollution and terrestrial carbon uptake introduces unforeseen uncertainty in China’s carbon neutrality goals.

Wendi Qu
Hao Hua
Chaoyang Wu

ResearchOpen Access10 Apr 2025

Nature Communications

Volume: 16, P: 1-11

No effect of dose, hepatic function, or nutritional status on 5-FU clearance following continuous (5-day), 5-FU infusion

RA Fleming
GA Milano
F Demard

Research01 Oct 1992

British Journal of Cancer

Volume: 66, P: 668-672

Treatment of advanced medullary thyroid cancer with an alternating combination of 5 FU-streptozocin and 5 FU-dacarbazine

M Schlumberger
N Abdelmoumene
JE Couette

Research01 Feb 1995

British Journal of Cancer

Volume: 71, P: 363-365

Ferredoxin reductase affects p53-dependent, 5-fluorouracil–induced apoptosis in colorectal cancer cells

Paul M. Hwang
Fred Bunz
Bert Vogelstein

Research01 Oct 2001

Nature Medicine

Volume: 7, P: 1111-1117

Substantial forest soil carbon accrual from absorptive fine roots over decadal timescales

The accrual of soil carbon from absorptive fine roots exceeds that of leaf litter in forests despite lower productivity, according to an analysis of field observations from Northern Hemisphere forest sites.

Ning Ma
Shenggong Li
Liang Kou

Research23 Sept 2025

Nature Geoscience

Volume: 18, P: 1020-1026

Natural products as inspiration for the development of asymmetric catalysis

Justin T. Mohr
Michael R. Krout
Brian M. Stoltz

Reviews17 Sept 2008

Nature

Volume: 455, P: 323-332

Verbascoside: Identification, Quantification, and Potential Sensitization of Colorectal Cancer Cells to 5-FU by Targeting PI3K/AKT Pathway

Yasmeen M. Attia
Dina M. El-Kersh
Mohamed M. Elmazar

ResearchOpen Access16 Nov 2018

Scientific Reports

Volume: 8, P: 1-12

LGR5 marks targetable tumor-initiating cells in mouse liver cancer

Cancer stem cells (CSCs) are thought to be the main drivers for disease progression and treatment resistance in liver cancer. This study identifies the LGR5+ compartment as an important CSC population, representing a viable therapeutic target for combating liver cancer.

Wanlu Cao
Meng Li
Qiuwei Pan

ResearchOpen Access23 Apr 2020

Nature Communications

Volume: 11, P: 1-16

Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis

During emergency myelopoiesis in mice, clusters of self-renewing granulocyte/macrophage progenitors (GMP) are transiently formed in the bone marrow cavity to produce a burst of myeloid cells; in leukaemia, GMP clusters persist and constantly generate myeloid leukaemia cells.

Aurélie Hérault
Mikhail Binnewies
Emmanuelle Passegué

Research29 Mar 2017

Nature

Volume: 544, P: 53-58

Comparison of imaging based single-cell resolution spatial transcriptomics profiling platforms using formalin-fixed paraffin-embedded tumor samples

Spatial cell distribution within a tissue microenvironment is a rapidly advancing field. Here, authors assess three commercially available single-cell resolution spatial transcriptomics approaches (CosMx, MERFISH, and Xenium) to inform which technology outperforms for immune profiling of solid tumors using patient samples.

Nejla Ozirmak Lermi
Max Molina Ayala
Luisa M. Solis Soto

ResearchOpen Access26 Sept 2025

Nature Communications

Volume: 16, P: 1-16

Targeting dormant tumor cells to prevent recurrent breast cancer: a randomized phase 2 trial

A combination of mouse model data and data from a randomized phase 2 trial in patients with breast cancer in remission demonstrates feasibility, safety and a reduction in residual tumor cells following treatment with hydroxychloroquine and/or everolimus.

Angela DeMichele
Amy S. Clark
Lewis A. Chodosh

Research02 Sept 2025

Nature Medicine

P: 1-11

Silent allele as genetic basis of fucosidosis

B. M. TURNER
N. G. BERATIS
K. HIRSCHHORN

Research02 Oct 1975

Nature

Volume: 257, P: 391-392

Integration of germline pharmacogenomic burden to predict fluoropyrimidine-related toxicity – A secondary analysis of the PREPARE trial

Elena De Mattia
Yoomi Park
Erika Cecchin

Research25 Sept 2025

Oncogene

P: 1-11

Evidence for polycyclic aromatic hydrocarbons detected in sulfates at Jezero crater by the Perseverance rover

The Perseverance rover detected polycyclic aromatic hydrocarbons preserved within sulfates in the fan and floor of Jezero crater on Mars, offering new insights into past habitability and the preservation of organic matter on Mars.

Teresa Fornaro
Sunanda Sharma
Amy J. Williams

Research04 Sept 2025

Nature Astronomy

P: 1-14

A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila

Thomas Préat
Pascal Thérond
Denise Busson

Research06 Sept 1990

Nature

Volume: 347, P: 87-89

Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma

The role of the tumour microenvironment in the response to immune checkpoint inhibitors in metastatic melanoma remains poorly understood. Here, single cell profiling of metastatic melanoma samples identifies associations of the mature dendritic enriched in immunoregulatory molecules subtype with immunotherapy response.

Jiekun Yang
Cassia Wang
Manolis Kellis

ResearchOpen Access01 Sept 2025

Nature Communications

Volume: 16, P: 1-19

FOXM1 modulates 5-FU resistance in colorectal cancer through regulating TYMS expression

Vidhya Varghese
Luca Magnani
Laura M. Kenny

ResearchOpen Access06 Feb 2019

Scientific Reports

Volume: 9, P: 1-16

Phase I dose-escalation trial of irinotecan with continuous infusion 5-FU first line, in metastatic colorectal cancer

M P Saunders
M Hogg
J W Valle

ResearchOpen Access28 Sept 2004

British Journal of Cancer

Volume: 91, P: 1447-1452

LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells

Regulation of self-renewal is critical during steady state and stress in haematpoietic stem cells (HSCs), and underlies leukaemia pathology. Here, the authors show that LIGHT and its receptor LTβR promote quiescence and self-renewal of HSCs and that LTβR deficiency promotes survival in a mouse leukaemia model.

S. S. Höpner
Ana Raykova
A. F. Ochsenbein

ResearchOpen Access16 Feb 2021

Nature Communications

Volume: 12, P: 1-16

Elliptic anisotropy measurement of the f₀(980) hadron in proton-lead collisions and evidence for its quark-antiquark composition

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

A. Hayrapetyan
A. Tumasyan
A. Zhokin

ResearchOpen Access27 Aug 2025

Nature Communications

Volume: 16, P: 1-19

Spatially resolved analysis of pancreatic cancer identifies therapy-associated remodeling of the tumor microenvironment

Spatial molecular imaging analysis of human pancreatic adenocarcinomas describes multicellular neighborhoods in the tumor microenvironment. Ligand–receptor analysis using optimal transport-based SCOTIA identifies interleukin-6 as a mediator of chemoresistance.

Carina Shiau
Jingyi Cao
William L. Hwang

Research03 Sept 2024

Nature Genetics

Volume: 56, P: 2466-2478

Alternative expression analysis by RNA sequencing

Alternative expression analysis by sequencing (ALEXA-seq) aligns RNA-seq reads from different cell types to a database of alternative expression sequence features and quantifies isoforms that are differentially expressed between samples.

Malachi Griffith
Obi L Griffith
Marco A Marra

Research12 Sept 2010

Nature Methods

Volume: 7, P: 843-847

Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium

Rapid turnover and regeneration of intestinal epithelium requires distinct intestinal stem cell (ISC) populations. Here the authors show p57 marks quiescent ISCs, and that differentiated cells revert to stem cell state after injury, through dynamic reprogramming characterized by fetal- and metaplastic-like changes.

Tsunaki Higa
Yasutaka Okita
Keiichi I. Nakayama

ResearchOpen Access21 Mar 2022

Nature Communications

Volume: 13, P: 1-17

Effects of nandrolone decanoate on the toxicity and anti-tumour action of CCNU and FU in murine tumours

M C Bibby
J A Double
M A Mughal

Research01 Oct 1981

British Journal of Cancer

Volume: 44, P: 572-577

Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene

J G Maring
A B P van Kuilenburg
E G E De Vries

ResearchOpen Access02 Apr 2002

British Journal of Cancer

Volume: 86, P: 1028-1033

Phase II study of irinotecan with bolus and high dose infusional 5-FU and folinic acid (modified de Gramont) for first or second line treatment of advanced or metastatic colorectal cancer

P Leonard
M T Seymour
J A Ledermann

ResearchOpen Access12 Nov 2002

British Journal of Cancer

Volume: 87, P: 1216-1220

5-FU therapeutic monitoring with dose adjustment leads to an improved therapeutic index in head and neck cancer

J Santini
G Milano
F Demard

Research01 Feb 1989

British Journal of Cancer

Volume: 59, P: 287-290

Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells

Lingfeng He
Hong Zhu
Zhigang Guo

ResearchOpen Access14 Aug 2018

Experimental & Molecular Medicine

Volume: 50, P: 1-12

International fisheries threaten globally endangered sharks in the Eastern Tropical Pacific Ocean: the case of the Fu Yuan Yu Leng 999 reefer vessel seized within the Galápagos Marine Reserve

Elisa Bonaccorso
Nicté Ordóñez-Garza
Juan M. Guayasamin

ResearchOpen Access22 Jul 2021

Scientific Reports

Volume: 11, P: 1-11

A prospective randomised trial to study the role of levamisole and interferon alfa in an adjuvant therapy with 5-FU for stage III colon cancer

W Schippinger
M Jagoditsch
R Jakesz

ResearchOpen Access26 Apr 2005

British Journal of Cancer

Volume: 92, P: 1655-1662

Microenvironment-triggered multimodal precision diagnostics

Multimodal nanosensors have been developed to target and respond to hallmarks in the tumour microenvironment and provide both a non-invasive urinary monitoring tool and an on-demand positron emission tomography imaging agent to localize tumour metastasis and assess response to therapy.

Liangliang Hao
Nazanin Rohani
Sangeeta N. Bhatia

Research15 Jul 2021

Nature Materials

Volume: 20, P: 1440-1448

Treatment of advanced medullary thyroid cancer with an alternating combination of doxorubicin-streptozocin and 5 FU-dacarbazine

M Nocera
E Baudin
M Schlumberger

ResearchOpen Access22 Aug 2000

British Journal of Cancer

Volume: 83, P: 715-718

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